<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12051

Description mediator of RNA polymerase II transcription subunit 12
SequenceMMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQSPSQGCGSPLPATSAEVDMAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECSEKVRPGEDELLKLLLPLLLQYLGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGPGAGGHPAHSILAQPGNALPPTPTSQPAGGNQPQTPFTDFYICPQHRPLVFGLSCMLQSIMLCCPSALVWHYSLTDSRNKTGSPLDLLPISPSNLPMPGGNGTFTQQVRAKVREIEEQVKDRGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLDKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPMLTEPSNESERVEFSNQVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESECKEAGSSVKNEDTGLSESMEIDHNSSTNFDEMFSPPMHCESKGSLSPKKTAQDPAFPLVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGDEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTGLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPVFMMEAIADPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPCPQAGAKSDNSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDEIADDDIGSKKSGGHTVSIETASLEIYAKYVLKSICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKVTIEVFQKSAEMNSSNPSGNSSAGAGSSTSNSNNTSKTKPVLSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMKSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSNKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVPQEPEKKMEALKPEKSVPVVSSDVTKKKPKKKKTPSTSKTEDYVTRTQGVVPYGTGLPPEILMGQQTHPYNRLDYSQQAMSMYAQNQPLPPGGPSLDIPYRPARNPQMGKIMPMRPNYPGVMPGGMPGMMGTEKQYPMGYKPQPNIPQGQILRQHLQVRLNQSIIGQQMRQMTPNQQYGSMQPTQNISQGYTTYGSHMGMQPHPSQVGGIVPPSYGNQGFQGSHPGANLGVVDSLRQMVQRPSGYVHQQAPGYSHTMQNTQRFPHQSIHQAPVMQGLSHMGTQGVHPGMRPNQILAEQQQAQQQQAQQQQQQYLRQQALRAQQQAQQQAQQQQVQQQQVQQQHQVQPQQVQQQQQQQQQQQVASAPPSGAQAQNQALSMQPMPPQQPMFPRQGMQQTQQQQQTAALVRQLQQQLSNTQPGQNTNSYY
Length2154
PositionKinase
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.07
Grand average of hydropathy-0.491
Instability index53.48
Isoelectric point6.88
Molecular weight240735.78
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12051
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     204.82|      22|      22|    2047|    2068|       1
---------------------------------------------------------------------------
 1872- 1893 (24.28/ 6.91)	NIPQG.......QIL.RQH...LQVRLNQSIIG
 1894- 1916 (29.46/10.01)	QQMRQ......mTPN.QQY...GSMQPTQNISQ
 1976- 1997 (31.88/11.46)	QAPGY.......SHT.MQN...TQRFPHQSIHQ
 2036- 2063 (33.73/12.56)	QQ.QQylrqqalRAQ.QQA...QQQAQQQQVQQ
 2064- 2086 (29.80/10.21)	QQVQQ.....qhQVQpQQV...QQQ.QQQQ.QQ
 2087- 2117 (24.04/ 6.76)	QQVAS.appsgaQAQ.NQAlsmQPMPPQQPMFP
 2118- 2139 (31.63/11.31)	RQGMQ.......QTQ.QQQ...QTAALVRQLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.32|      23|      23|    1821|    1843|       2
---------------------------------------------------------------------------
 1723- 1740 (29.47/12.77)	PPTPVPQEPEK...KME.....AL..KP
 1798- 1818 (31.54/14.24)	NRLD..YSQQAMS.MYA..QNQPL..PP
 1821- 1843 (43.81/22.98)	PSLDIPYRPARNP.QMG..KIMPM..RP
 1846- 1869 (25.49/ 9.93)	PGV....MPGGMPgMMGteKQYPMgyKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.55|      51|      59|    1021|    1077|       3
---------------------------------------------------------------------------
 1021- 1077 (75.76/61.18)	FVCNVlmDVC.VDHRDpERVNDIGIL....CAELTAYCRSLSAEwlGVLKAlCCSSNNGNCG
 1081- 1136 (77.80/42.44)	LLCNV..DVSdLSFHD.SLATFVAILiarqCLLLEDLVRCVAIP..SLLNA.ACSEQDSEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.31|      30|      37|    1243|    1279|       6
---------------------------------------------------------------------------
 1242- 1275 (45.12/36.33)	L.EIYAKYVLKSICqqewVGERCLKSLSEDSSALQ
 1279- 1309 (50.19/22.53)	LvNIQAQRLLQLIC....YPHRQLDSEEGDNPQRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.65|      13|      37|     197|     209|       7
---------------------------------------------------------------------------
  197-  209 (25.11/15.89)	WEQLQKVAEFYRQ
  233-  245 (26.53/17.21)	WEYNEKLAMFMFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.89|      13|      31|     827|     839|      10
---------------------------------------------------------------------------
  827-  839 (23.38/14.85)	FALG.MSYHLPLVQ
  843-  856 (16.88/ 8.45)	FIFDlMEYSLNISG
  860-  872 (18.63/10.18)	FAIQ.LLNELSLVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.07|      40|      82|     691|     730|      11
---------------------------------------------------------------------------
  691-  730 (72.20/43.73)	ESKGSLSPKKTAQDP.AFPLVYEQPRHIQYATHFPIPQEES
  774-  814 (66.87/39.92)	ETGGDEGQKRKRSKPeAFPTAEDIFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.05|      23|      24|    1525|    1548|      15
---------------------------------------------------------------------------
 1525- 1548 (32.04/21.31)	RSTQQTTEwAVL.LLDIISSGTV..DM
 1549- 1574 (28.01/12.98)	KSNNELFT.TVLdMLSVLINGTLaaDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.90|      15|      16|    1637|    1652|      18
---------------------------------------------------------------------------
 1637- 1652 (21.52/15.07)	KgNKIAGFEK.EGLQVS
 1654- 1669 (24.38/12.13)	K.QKISPWDVfEGLKHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.02|      16|     718|     492|     507|      25
---------------------------------------------------------------------------
  492-  507 (32.11/22.44)	GSGQSKD.GHEMSPDDD
 1208- 1224 (26.90/17.25)	GSGFSHPaGLDEIADDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12051 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDSHLPRPRSPSDEPSDESECKEAGSSVKNEDTGLSESMEIDHNSSTNFDEMFSPPMHCESKGSLSPK
2) GTGLPPEILMGQQTHPYNRLDYSQQAMSMYAQNQPLPPGGPSLDIPYRPARNPQMGKIMPMRPNYPGVMPGGMPGMMGTEKQYPMGYKPQPNIPQGQILRQHLQVRLNQSIIGQQMRQMTPNQQYGSMQPTQNISQGYTTYGSHMGMQPHPSQVGGIVPPSYGNQGFQGSHPGANLGVVDSLRQMVQRPSGYVHQQAPGYSHTMQNTQRFPHQSIHQAPVMQGLSHMGTQGVHPGMRPNQILAEQQQAQ
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
4) SAEMNSSNPSGNSSAGAGSSTSNSNNTSKTKPV
5) SYYLEPLPLPPEEEEPPTPVPQEPEKKMEALKPEKSVPVVSSDVTKKKPKKKKTPSTSKTEDYVTRTQGVVP
6) VLKAAGEELEKGQHLGSSSRKERDRQKQKS
7) VQPQQVQQQQQQQQQQQVASAPPSGAQAQNQALSMQPMPPQQPMFPRQGMQQTQQQQ
631
1781
16
1360
1708
1419
2072
699
2029
65
1392
1779
1448
2128










Molecular Recognition Features






MoRF SequenceStartStop




NANANA