<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12046

Description mediator of RNA polymerase II transcription subunit 23 isoform X2
SequenceMAISMETQLQSIFEDVVKTEVIEEAFAGMFMDTPEDERTKLISCLGAFRQYWSTLPPDSHDQCVQWIVRFIHGQHSPKRISFLYDCLAMAVETSLLPPRMVCQALISSDNLEWERTQLWALTFRLIRKIIGGVDYKGVRDLLKALLDKIQTIPNTVSSAVVQQLLAAREVVEYILDRNACLLPAYFAITEIRKLYPEGMLSHWLLGSLMSDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPFDKDLFEPQTGLLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDISKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLGMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCTASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPMQQQSHYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRAPGWCLSETYIKCGMNPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLSVVLKSQPLVPRENITAWMNAIGLVITALPEPYWVVLQDRIVSVLGSPCFTTETEWVGYPFALLDFTACHQSYSEMYCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSQHLSYMDPICDFLYHIKYMFTGDSVKDQVEKIILTLRPAMKLRLRFITHTSKMEPAAASVPQPSSSVSSPAPQSNPGPSNLPLSVAQ
Length1382
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.10
Grand average of hydropathy-0.021
Instability index45.50
Isoelectric point7.09
Molecular weight157746.39
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12046
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.24|      25|      31|     478|     507|       1
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  478-  502 (45.78/32.41)	GMTDYKIALLCNAYSTNSECFTLPM
  511-  535 (45.46/21.70)	GNGSMRITLPGTNCTASGSVTPLPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     405.57|     137|     616|     211|     389|       2
---------------------------------------------------------------------------
  211-  371 (196.85/166.34)	DF.VDSFRPTARINSIcGRCslLPVVNNsgaicNSWKLDPTTL.RFPL.RGMLPFDKDlfEPQTG..LLRYVLEQPYS.RDMVCNMLglnKQtlNIAQHkqrcpVLE.DQLVDLVVYamERSETEEQFDDGGTSQL...LWQHLSSQLIFF..VLFQFasFPHMVLSLHQKLA
  838-  986 (208.72/115.59)	DFlVYEFSTSAGGQQL.NKC..IEILND.....MVWKYNIVTLdRLILcLAMRSHEGN..EAQVCyfIIQLLLLKPNDfRNRVSDFV...KE..NAPEH.....WLQsDWHTKHMTY..HKKYPEKLYFEGLAEQVnppMQQQSHYLPIYFgnVCLRF..LPVFDIVIHRFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.78|      15|      15|    1005|    1019|       3
---------------------------------------------------------------------------
 1005- 1019 (28.96/16.91)	YKFHDRPVTYLYNTL
 1022- 1036 (24.82/13.53)	YERHLRDRTNLKRKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.53|      50|     697|      33|      93|       4
---------------------------------------------------------------------------
   33-   93 (77.49/72.96)	TPEDERTKLISCLGA.....FRQywSTLPPDSH.....................DqcvqwIVRFIHGQHSPKrisfLYDCL..AMAVET
  733-  810 (74.04/42.16)	TPHNWASHTLSCFPAplqafFKQ..NNVPQESRfnlkknveeeyrkwksmtnenD.....IITHFSMQGSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.68|      14|      18|    1052|    1066|       5
---------------------------------------------------------------------------
 1052- 1066 (26.19/19.52)	WCLSETYIkCGMNPR
 1071- 1084 (29.48/17.30)	WIPDDTYY.CKLIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.84|      18|      18|    1192|    1209|       6
---------------------------------------------------------------------------
 1192- 1209 (35.55/22.44)	E.WVGYPFALLDFTACHQS
 1212- 1230 (30.29/17.95)	EmYCSYVLALAHAVWHHSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.47|      24|     620|     632|     682|       8
---------------------------------------------------------------------------
  644-  671 (36.81/68.60)	PQTNQNQLHL.CVESTALrlitALGSSEV
 1108- 1132 (39.66/10.27)	PNPAAHALHVtCVELMAL....AVPGKDV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12046 with Med23 domain of Kingdom Metazoa
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