<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12045

Description mediator of RNA polymerase II transcription subunit 23 isoform X4
SequenceMAISMETQLQSIFEDVVKTEVIEEAFAGMFMDTPEDERTKLISCLGAFRQYWSTLPPDSHDQCVQWIVRFIHGQHSPKRISFLYDCLAMAVETSLLPPRMVCQALISSDNLEWERTQLWALTFRLIRKIIGGVDYKGVRDLLKALLDKIQTIPNTVSSAVVQQLLAAREVVEYILDRNACLLPAYFAITEIRKLYPEGMLSHWLLGSLMSDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPFDKDLFEPQTGLLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDISKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLGMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCTASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPMQQQSHYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRAPGWCLSETYIKCGMNPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLSVVLKSQPLVPRENITAWMNAIGLVITALPEPYWVVLQDRIVSVLGSPCFTTETEWVGYPFALLDFTACHQSYSEMYCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSQHLSYMDPICDFLYHIKYMFTGDSVKDQVEKIILTLRPAMKLRLRFITHTSKMEPAAASVPQPSSSVSSPAPQSNPGPSNLPLSVAQ
Length1376
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.10
Grand average of hydropathy-0.023
Instability index45.33
Isoelectric point7.09
Molecular weight157105.66
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12045
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     283.80|     101|     785|      73|     218|       1
---------------------------------------------------------------------------
   73-  218 (135.66/183.90)	GQHSPKRISFLYD...............CLAMAVETSllPPRMVCQALIssdnlewertqlwaltfRLirkiiggvdykgvrdllkaLLDKIQTIPNTVSSAVVQQllAAR............................EVVEYILDRNACLLPAYFA.............ITEIRKLYP.....EGMLSHwlLGSLMSdFVDsfRP
  844- 1005 (148.14/98.23)	GQQLNKCIEILNDmvwkynivtldrlilCLAMRSHEG..NEAQVCYFII.................QL...................LLLKPNDFRNRVSDFVKEN..APEhwlqsdwhtkhmtyhkkypeklyfeglaEQVNPPMQQQSHYLPIYFGnvclrflpvfdivIHRFLELLPvskslETLLDH..LGGLYK.FHD..RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.70|      23|     462|     638|     665|       3
---------------------------------------------------------------------------
  638-  660 (39.23/27.78)	PQ....TNQNQLHLCVESTALR..LITAL
  667-  695 (26.48/ 8.18)	PQftrfLSDPKTVLSAESEELNraLILTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.68|      14|      18|    1046|    1060|       6
---------------------------------------------------------------------------
 1046- 1060 (26.19/19.35)	WCLSETYIkCGMNPR
 1065- 1078 (29.48/17.13)	WIPDDTYY.CKLIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.84|      18|      18|    1186|    1203|       7
---------------------------------------------------------------------------
 1186- 1203 (35.55/18.86)	E.WVGYPFALLDFTACHQS
 1206- 1224 (30.29/15.11)	EmYCSYVLALAHAVWHHSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12045 with Med23 domain of Kingdom Metazoa
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