<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12044

Description mediator of RNA polymerase II transcription subunit 23 isoform X1
SequenceMAISMETQLQSIFEDVVKTEVIEEAFAGMFMDTPEDERTKLISCLGAFRQYWSTLPPDSHDQCVQWIVRFIHGQHSPKRISFLYDCLAMAVETSLLPPRMVCQALISSDNLEWERTQLWALTFRLIRKIIGGVDYKGVRDLLKALLDKIQTIPNTVSSAVVQQLLAAREVVEYILDRNACLLPAYFAITEIRKLYPEGMLSHWLLGSLMSDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPFDKDLFEPQTGLLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDISKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLGMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCTASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRYTTKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPMQQQSHYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRAPGWCLSETYIKCGMNPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLSVVLKSQPLVPRENITAWMNAIGLVITALPEPYWVVLQDRIVSVLGSPCFTTETEWVGYPFALLDFTACHQSYSEMYCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSQHLSYMDPICDFLYHIKYMFTGDSVKDQVEKIILTLRPAMKLRLRFITHTSKMEPAAASVPQPSSSVSSPAPQSNPGPSNLPLSVAQ
Length1386
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.10
Grand average of hydropathy-0.026
Instability index45.22
Isoelectric point7.19
Molecular weight158239.94
Publications









Function






Annotated function


ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12044
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.33|      84|     691|      33|     164|       1
---------------------------------------------------------------------------
   33-  156 (108.76/165.55)	TPEDERTKLISCLGA.....FRQywSTLPPDSH.....................DqcvqwIVRFIHGQHSPKrisfLYDCL..AMAVETsllpprmvcqalissDNLEwertqlwALTFRLIRKIIGGVDYKgvrdllkALLDKIQTIPNTV
  733-  844 (130.57/86.84)	TPHNWASHTLSCFPAplqafFKQ..NNVPQESRfnlkknveeeyrkwksmtnenD.....IITHFSMQGSPP....LFLCLlwKMLLET...............DHIN.......QIGFRYTTKVLERIGAR.......ALVAHVRTFADFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.30|      15|      31|     500|     515|       2
---------------------------------------------------------------------------
  500-  515 (23.11/19.75)	LPMGvLVETIYGNGSM
  533-  547 (26.19/17.07)	LPMN.LLDSLTVHAKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.87|      13|      33|     419|     433|       3
---------------------------------------------------------------------------
  419-  433 (20.90/17.76)	IPVPDISKPQstHAF
  455-  467 (25.97/15.07)	IPIPHSLKLH..HEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.78|      15|      15|    1009|    1023|       4
---------------------------------------------------------------------------
 1009- 1023 (28.96/17.60)	YKFHDRPVTYLYNTL
 1026- 1040 (24.82/14.05)	YERHLRDRTNLKRKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      30|     349|     358|       5
---------------------------------------------------------------------------
  349-  358 (18.69/10.06)	IFFVLFQFAS
  382-  391 (19.45/10.78)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.07|      14|      26|     632|     645|       6
---------------------------------------------------------------------------
  632-  645 (23.82/13.42)	QLLSHLHSLAAVPQ
  661-  674 (23.25/12.92)	RLITALGSSEVQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.68|      14|      18|    1056|    1070|       9
---------------------------------------------------------------------------
 1056- 1070 (26.19/19.93)	WCLSETYIkCGMNPR
 1075- 1088 (29.48/17.65)	WIPDDTYY.CKLIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.84|      18|      18|    1196|    1213|      10
---------------------------------------------------------------------------
 1196- 1213 (35.55/19.12)	E.WVGYPFALLDFTACHQS
 1216- 1234 (30.29/15.31)	EmYCSYVLALAHAVWHHSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.32|      21|     691|     181|     204|      13
---------------------------------------------------------------------------
  182-  202 (40.36/24.70)	LPAYFA.............ITEIRKLYP.....EGMLSH
  966- 1004 (23.96/ 8.28)	LPIYFGnvclrflpvfdivIHRFLELLPvskslETLLDH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12044 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AASVPQPSSSVSSPAPQSNPGPSNLPLSVA
1356
1385










Molecular Recognition Features






MoRF SequenceStartStop




NANANA