<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12044

Description mediator of RNA polymerase II transcription subunit 23 isoform X1
SequenceMAISMETQLQSIFEDVVKTEVIEEAFAGMFMDTPEDERTKLISCLGAFRQYWSTLPPDSHDQCVQWIVRFIHGQHSPKRISFLYDCLAMAVETSLLPPRMVCQALISSDNLEWERTQLWALTFRLIRKIIGGVDYKGVRDLLKALLDKIQTIPNTVSSAVVQQLLAAREVVEYILDRNACLLPAYFAITEIRKLYPEGMLSHWLLGSLMSDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPFDKDLFEPQTGLLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDISKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLGMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCTASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRYTTKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPMQQQSHYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRAPGWCLSETYIKCGMNPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLSVVLKSQPLVPRENITAWMNAIGLVITALPEPYWVVLQDRIVSVLGSPCFTTETEWVGYPFALLDFTACHQSYSEMYCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSQHLSYMDPICDFLYHIKYMFTGDSVKDQVEKIILTLRPAMKLRLRFITHTSKMEPAAASVPQPSSSVSSPAPQSNPGPSNLPLSVAQ
Length1386
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.10
Grand average of hydropathy-0.026
Instability index45.22
Isoelectric point7.19
Molecular weight158239.94
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12044
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.33|      84|     691|      33|     164|       1
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   33-  156 (108.76/165.55)	TPEDERTKLISCLGA.....FRQywSTLPPDSH.....................DqcvqwIVRFIHGQHSPKrisfLYDCL..AMAVETsllpprmvcqalissDNLEwertqlwALTFRLIRKIIGGVDYKgvrdllkALLDKIQTIPNTV
  733-  844 (130.57/86.84)	TPHNWASHTLSCFPAplqafFKQ..NNVPQESRfnlkknveeeyrkwksmtnenD.....IITHFSMQGSPP....LFLCLlwKMLLET...............DHIN.......QIGFRYTTKVLERIGAR.......ALVAHVRTFADFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.30|      15|      31|     500|     515|       2
---------------------------------------------------------------------------
  500-  515 (23.11/19.75)	LPMGvLVETIYGNGSM
  533-  547 (26.19/17.07)	LPMN.LLDSLTVHAKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.87|      13|      33|     419|     433|       3
---------------------------------------------------------------------------
  419-  433 (20.90/17.76)	IPVPDISKPQstHAF
  455-  467 (25.97/15.07)	IPIPHSLKLH..HEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.78|      15|      15|    1009|    1023|       4
---------------------------------------------------------------------------
 1009- 1023 (28.96/17.60)	YKFHDRPVTYLYNTL
 1026- 1040 (24.82/14.05)	YERHLRDRTNLKRKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      30|     349|     358|       5
---------------------------------------------------------------------------
  349-  358 (18.69/10.06)	IFFVLFQFAS
  382-  391 (19.45/10.78)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.07|      14|      26|     632|     645|       6
---------------------------------------------------------------------------
  632-  645 (23.82/13.42)	QLLSHLHSLAAVPQ
  661-  674 (23.25/12.92)	RLITALGSSEVQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.68|      14|      18|    1056|    1070|       9
---------------------------------------------------------------------------
 1056- 1070 (26.19/19.93)	WCLSETYIkCGMNPR
 1075- 1088 (29.48/17.65)	WIPDDTYY.CKLIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.84|      18|      18|    1196|    1213|      10
---------------------------------------------------------------------------
 1196- 1213 (35.55/19.12)	E.WVGYPFALLDFTACHQS
 1216- 1234 (30.29/15.31)	EmYCSYVLALAHAVWHHSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.32|      21|     691|     181|     204|      13
---------------------------------------------------------------------------
  182-  202 (40.36/24.70)	LPAYFA.............ITEIRKLYP.....EGMLSH
  966- 1004 (23.96/ 8.28)	LPIYFGnvclrflpvfdivIHRFLELLPvskslETLLDH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12044 with Med23 domain of Kingdom Metazoa
Unable to open file!