<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12039

Description mediator of RNA polymerase II transcription subunit 12-like
SequenceMMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVTRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQSPSQGCGSPLPANPAEVDTAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLKLLLPLLLQYSGEFVLSAYLSRRLAYFCTRRLNLLLSDGSLGPGAGGHPAHSILAQPGNALPPTPTSQPTGGNQPQTPFTDFYICPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPISPSNLPMPGGNSTFTQQVRAKVREIEEQVKDRGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPMLTEAGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDAGSSVKNEDTGLSESMEIDHNSSANFDEMFSPPTHCESKGSPSPEKPAPEQEGKGACKDKALDPAFPLVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRTKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTGLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCCHLKSKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPVFMMEAIANPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPCPQDGAKSDKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIADDDMGSKKSGGRTVSIETASLDVYAKYVLKSICQQEWVGERCLRSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKHILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSTNLSGNGSAGAGGSASNSNNPSKKPVLSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEDEEPPTPAPQEPEKKMAEPVKPEKSVPAVSSDSTKKKTKKKKTPSTNKTEDYVTRTQGGVPYGTCIPPDPLMSQQAHPYSRIGYNQQPMGMYAQNQPLPPGGPGLDTPYRPARNPQIGKMMPTRPSYPGMMPGMQGGMPGMMGMDKQYPMGYKPQPNIPQGQILRQQLQVRLNQSMIGQQMRQMTPNQQYSSMQPSQNISQGYTTYGSHIGMQPHPSQAGGIVPPSYGNQGFQGSHPGANPAVVDSLRQRPSGYVHQQAPGYSHTMQNTPRFPHQPIQPAPVMQPLSHMGGQGVHPGMRPNQMLAEQQQQQQAQQQQAQQQQQQYLRQQALRAQQQAQQQQQQQQQAQQQQQQQQQAQQQQQQQQAQQQQQQQQQVQQQQQVQQQQQVQQQQQVQQQVQPQQVQQQQQQQQQQQQQQQQVASAQPPGTQAQNQALAMQPLPPQQPMFPRQGMQQTQMQQTQQQQQTAALVRQLQQQLSNTQPGQNTNSYY
Length2223
PositionKinase
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.07
Grand average of hydropathy-0.571
Instability index56.74
Isoelectric point6.79
Molecular weight248663.81
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12039
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     232.06|      18|      18|    2071|    2088|       1
---------------------------------------------------------------------------
 2042- 2061 (32.46/10.06)	QQQQAQQQQA..QQQQQQylRQ
 2062- 2078 (27.65/ 7.54)	QALRAQQQ...aQQQQQQ..QQ
 2079- 2098 (37.67/12.81)	QAQQQQQQQQqaQQQQQQ..QQ
 2099- 2115 (30.30/ 8.93)	.AQQQQQQQQ..QVQQQQ..QV
 2116- 2134 (31.53/ 9.58)	QQQQQVQQQQ.qVQQQVQ..PQ
 2135- 2152 (41.17/14.64)	QVQQQQQQQQ..QQQQQQ..QQ
 2183- 2200 (31.28/ 9.44)	QGMQQTQMQQ..TQQQQQ..TA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1650|    1664|       3
---------------------------------------------------------------------------
 1650- 1664 (20.41/18.37)	TKgNKIAGFEK.EGLQ
 1667- 1681 (22.26/13.66)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.21|      23|      26|    1817|    1839|       4
---------------------------------------------------------------------------
 1785- 1806 (24.91/ 7.65)	YVTRTQGGVPYGTCIPP..DPLMS
 1817- 1839 (47.20/22.20)	YNQQPMGMYAQNQPLPP.GGPGLD
 1980- 1996 (23.99/ 7.05)	LRQRPSG.YVHQQ......APGYS
 2005- 2028 (26.11/ 8.43)	FPHQPIQPAPVMQPLSHmGGQGVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.57|      25|      26|    1268|    1292|       5
---------------------------------------------------------------------------
 1268- 1292 (44.42/27.35)	ICQQEWVGERCLRSLSEDSSALQDP
 1297- 1321 (44.16/27.14)	IQAQRLLQLICYPHRQLDSEEGDNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.00|      67|     166|    1392|    1490|       6
---------------------------------------------------------------------------
 1392- 1467 (98.37/83.43)	GGSASNSNNPSKKPVLsssERSGVWLVAPLIAKLPTSVQGHVL..KAAGEELEKgqHLgsssRKE.RDRQK...QKSMSLLS
 1558- 1630 (98.64/58.48)	GTVDMQSNNELFTTVL...DMLSVLINGTLAADMSSISQGSMEenKRAYMNLVK..KL....RKElGDRQSeslEKVRQLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.71|      12|      15|    1005|    1016|       7
---------------------------------------------------------------------------
 1005- 1016 (22.62/12.76)	MMEAIANPSAHN
 1021- 1032 (21.10/11.38)	MVGKILNDSPAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.65|      13|      35|     197|     209|       8
---------------------------------------------------------------------------
  197-  209 (25.11/16.11)	WEQLQKVAEFYRQ
  233-  245 (26.53/17.47)	WEYNEKLAMFMFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.50|      15|      15|    1895|    1909|       9
---------------------------------------------------------------------------
 1895- 1909 (25.05/13.52)	QILRQQLQVRLNQSM
 1912- 1926 (28.46/16.56)	QQMRQMTPNQQYSSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      13|      35|     842|     854|      10
---------------------------------------------------------------------------
  842-  854 (24.12/16.55)	FALGMSYHLPLVQ
  875-  887 (20.76/13.06)	FAIQLLNELSLVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.29|      26|      31|    1140|    1167|      12
---------------------------------------------------------------------------
 1140- 1167 (42.02/31.85)	NAACSEQDSEPGARLTCRIllHLFKTPQ
 1173- 1198 (43.26/26.58)	QDGAKSDKSSVGIRSSCDR..HLLAASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.60|      18|      35|     254|     277|      20
---------------------------------------------------------------------------
  254-  277 (26.12/32.83)	FLTWVLECFEKVRpgedelLKLLL
  292-  309 (32.48/21.85)	YLSRRLAYFCTRR......LNLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.71|      24|     161|    1520|    1552|      21
---------------------------------------------------------------------------
 1486- 1509 (41.88/28.87)	REGLLTSLYSQVQ...QIVTNWREDQY
 1526- 1552 (35.82/25.23)	RLNLVGGMFDTVQrstQQTTEWAVLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.81|      26|      83|    1843|    1876|      22
---------------------------------------------------------------------------
 1843- 1870 (50.34/36.24)	RPARNpqIGKMMPTRPSYPGMM..PGMQGG
 1927- 1954 (44.47/14.85)	QPSQN..ISQGYTTYGSHIGMQphPSQAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.53|      18|      35|     139|     156|      23
---------------------------------------------------------------------------
  139-  156 (30.37/19.71)	KKEEVFGYLAKYTVPVTR
  177-  194 (33.16/22.24)	KKRHVIDPCIEWTQIITK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12039 with Med12 domain of Kingdom Metazoa
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