<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12038

Description mediator of RNA polymerase II transcription subunit 25-like isoform X3
SequenceMDLPIKPGANQVADVVFVIEGTANLGPYFESLRKHYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVSPRKLPALRALFDRASPVGGPVDPHPDYSQDPFHMILVRGISLPVSSGGGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLPQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPIANQQTPPSSQPGMPGVSAAQANPIGGQQQGVANKIVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVNQGENLNADQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMATGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVVVGMPSVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVMEDEILMDLI
Length744
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.05
Grand average of hydropathy-0.292
Instability index53.07
Isoelectric point8.49
Molecular weight79458.01
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12038
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.70|      20|      25|     325|     348|       1
---------------------------------------------------------------------------
  335-  355 (38.39/ 8.82)	PQQQQVQPPGQPQP.nQQQPVP
  545-  566 (23.31/ 6.20)	VQQHRSLGSGGPMPgpPGQVQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.77|      25|      25|     674|     698|       2
---------------------------------------------------------------------------
  274-  293 (28.59/ 6.92)	VEAANNQ.....KSRFPGM.VNPG...PP
  606-  632 (32.47/ 9.12)	QQRQANLMTMRASGA.PNQ.QLPVtgaPP
  682-  704 (29.23/ 7.28)	HQGLGGQLVHPTPGAGP..qMQAQ...W.
  705-  729 (48.47/18.22)	RQPLAGQMMMAAGQRGPGA.QPPG...MP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.00|      29|      56|     303|     331|       3
---------------------------------------------------------------------------
  218-  242 (38.40/11.05)	VRGISLPVSSG..GGSGPLK.....PILPPQP
  245-  273 (36.34/10.08)	VSQPPLGPASQapPPISTAHPYQA.A..AQMA
  303-  331 (47.59/15.38)	VAGVKLAPSSQ..PSLSTVTTVST.PMLPQQQ
  362-  391 (41.67/12.59)	IANQQTPPSSQ..PGMPGVSAAQAnPIGGQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.53|      53|      55|      46|     100|       4
---------------------------------------------------------------------------
   38-   84 (61.24/43.65)	..........LPAIEYfnGGPPAET.DFGGDygGTQYGLVVFNTVDCAPESYVQCHAP
   85-  138 (75.37/46.94)	TSSAFEFVSWIDSIQFmgGG..AEScSLIAE..GLSVALQLFDDFKKMREQIGQTHKV
  143-  164 (22.92/ 8.03)	CNSPPYLLPAVESVSY..TGCTAD..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.17|      28|      74|     423|     454|       5
---------------------------------------------------------------------------
  423-  454 (39.64/35.88)	RSLPCQVQVNQgeNLNADQwpQKLIMQLIPQQ
  500-  527 (48.52/27.96)	HSAPCEVRVLM..LLYSSK..KRIFMGLIPND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.39|      16|      24|     640|     657|       7
---------------------------------------------------------------------------
  640-  657 (26.13/16.89)	QAPPQGAMLRLPnpGANP
  666-  681 (33.26/15.29)	QQQPQGGVGHMQ..GMMP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12038 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLPQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPIANQQTPPSSQPGMPGVSAAQANPIGGQQQ
2) KQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVV
3) SVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVME
229
543
596
391
591
736










Molecular Recognition Features






MoRF SequenceStartStop




NANANA