<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12037

Description mediator of RNA polymerase II transcription subunit 25-like isoform X3
SequenceMDLPIKPGANQVADVVFVIEGTANLGPYFESLRKHYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVSPRKLPALRALFDRASPVGGPVDPHPDYSQDPFHMILVRGISLPVSSGGGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLTQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPTANQQTPPSSQPGMPGVSAAQANPIGGQQQGVANKIVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVNQGENLNADQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMATGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVVVGMPSVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVMEDEILMDLI
Length744
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.05
Grand average of hydropathy-0.298
Instability index52.45
Isoelectric point8.49
Molecular weight79449.95
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     609.50|      93|      93|     236|     328|       1
---------------------------------------------------------------------------
  187-  258 (80.06/17.01)	...............ALRALFDRASPVGGPVDPH......PDY...................................SQDPfHMILVRGI...SLPVSS........gggsgplkP...IL.......PPQPLPVSQ.PP..LG...PASQAPP
  259-  354 (144.62/35.60)	P.ISTAHPYQAAAQMAVEAANNQKSRFPGMVNPG......PPF..SGQSTL..PSVA.......G........VKLAPSSQP.SLSTVTTV...STPMLT..............qqQ...AP.......PPQQQQV.Q.PP...GqpqPNQQQPV
  355-  444 (111.33/26.02)	P.PQQQQP..TANQ......QTPPSSQPGM..PGvsaaqaNPI..GGQQ....QGVAnkivawsG........V.LEWQEKP.KASSMD.....SNTKLT................R...SL.......PCQ.VQVNQ.GE..NL...NADQWPQ
  445-  559 (99.55/22.63)	KlIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDV......ESL..KGLYRImaTGFA.......G........CVHFPHSAP.CEVRVLMLlysSKKRIFmglipndqsgfvngirQ...VI.......TNHKQVQQH.RS..LG...SGGPMPG
  560-  643 (64.88/12.64)	P..........................PGQVQPN......QNFlnRPQGPI..PVSH.......GnvqqqsvvVGM.....P.SVSQVT.........LM.........eeqqrqaN...LMtmrasgaPNQQLPVTGaPPnqVT...QGGQAPP
  651-  729 (109.05/25.36)	P.NPGANPQLRSLLLSQQQPQGGVGHMQGMM.PH......QGL..GGQLVH..PT......................PGAGP.QMQ..AQW...RQP.LA................GqmmMA.......AGQRGPGAQ.PP..GM...P......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      16|     111|      36|      51|       2
---------------------------------------------------------------------------
   36-   51 (31.77/23.27)	YILPAIEYFN.GGPPAE
  148-  164 (24.96/16.30)	YLLPAVESVSyTGCTAD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12037 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLTQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPTANQQTPPSSQPGMPGVSAAQANPIGGQQQ
2) KQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVV
3) SVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVME
229
543
596
391
591
736










Molecular Recognition Features






MoRF SequenceStartStop




NANANA