<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12036

Description mediator of RNA polymerase II transcription subunit 25-like isoform X2
SequenceMDLPIKPGANQVADVVFVIEGTANLGPYFESLRKHYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVSPRKLPALRALFDRASPVGGPVDPHPDYSQDPFHMILVRGISLPVSSGGGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLPQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPIANQQTPPSSQPGMPGVSAAQANPIGGQQQGVANKIVAWSGVLEWQEPKASSMDSNTKLTRSLPCQVQVNQGENLNADQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMATGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVVVGMPSVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVMEDEILMDLI
Length752
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.05
Grand average of hydropathy-0.291
Instability index53.99
Isoelectric point8.30
Molecular weight80205.81
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12036
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.13|      24|      24|     334|     357|       1
---------------------------------------------------------------------------
  244-  269 (34.28/ 6.82)	P....vsqpPLGPASQAPPP..ISTAHPYQPP
  301-  324 (33.34/ 6.44)	P........PFSGQSTLPSVAGVKLAPSSQPS
  325-  356 (42.65/10.23)	LstvttvstPMLPQQQAPPPQQQQVQPPGQPQ
  566-  586 (32.86/ 6.24)	P..........GPPGQVQPNQNFLNRPQG.PI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.85|      12|     131|     601|     614|       2
---------------------------------------------------------------------------
  601-  614 (18.42/11.17)	GMPSVSqvTLMEEQ
  735-  746 (23.44/ 8.63)	GMPQVS..SVMEDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     164.81|      23|      23|     631|     653|       3
---------------------------------------------------------------------------
  197-  223 (29.62/ 7.26)	PV.GGPVD........PHPD............YSQD......P.fhmilvR..G..ISL
  362-  381 (37.51/11.60)	PVP..PQQ........QQPI............ANQQ......TP.........P..SSQ
  634-  658 (37.57/11.63)	PVTGAPPN........QVTQ............GGQA......PP......Q..GamLRL
  659-  697 (28.24/ 6.50)	PNPGANPQlrslllsqQQPQ............GGVGhmqgmmPH......QglG..GQL
  700-  733 (31.87/ 8.50)	PTPGAGPQ........MQAQwrqplagqmmmaAGQR......GP.........G..AQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.85|      39|      55|      46|     100|       4
---------------------------------------------------------------------------
   38-   82 (57.36/65.22)	LPAIEYfnGGppAET.DFGGDygGTQYGLVVFNTVDCAPESYVQCH
   95-  136 (56.49/26.62)	IDSIQFmgGG..AEScSLIAE..GLSVALQLFDDFKKMREQIGQTH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12036 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLPQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPIANQQTPPSSQPGMPGVSAAQANPIGGQQQ
2) KQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVV
3) SVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVME
229
551
604
400
599
744










Molecular Recognition Features






MoRF SequenceStartStop




NANANA