<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12035

Description mediator of RNA polymerase II transcription subunit 25-like isoform X2
SequenceMDLPIKPGANQVADVVFVIEGTANLGPYFESLRKHYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVSPRKLPALRALFDRASPVGGPVDPHPDYSQDPFHMILVRGISLPVSSGGGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLTQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPTANQQTPPSSQPGMPGVSAAQANPIGGQQQGVANKIVAWSGVLEWQEPKASSMDSNTKLTRSLPCQVQVNQGENLNADQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMATGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVVVGMPSVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVMEDEILMDLI
Length752
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.05
Grand average of hydropathy-0.297
Instability index53.38
Isoelectric point8.30
Molecular weight80197.74
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12035
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     452.92|      54|      57|     287|     340|       1
---------------------------------------------------------------------------
  193-  234 (44.47/ 9.87)	.DRASPVGGPVDPHP....DY..S.QDPFHMilVR..GISLPVSSG..GG.............S.G.PL.....
  238-  276 (43.78/ 9.58)	......LP....PQP.............LP...VS..QPPLGPASQapPPI.....STAHP.YQpP.PSLNAAQ
  287-  340 (89.20/28.38)	NNQKSRFPGMVNPGP....PF..SGQSTLPS..VA..GVKLAPSSQ..PSL.....STVTT.VS.T.PMLTQQQ
  345-  400 (83.35/25.96)	QQQQVQPPG..QPQPnqqqPV..PPQQQQPT...A..NQQTPPSSQ..PGM.....PGVSA.AQ.AnPIGGQQQ
  568-  615 (52.57/13.22)	......PPGQVQPNQ....NFlnRPQGPIP...VShgNVQ.QQSVV..VGM.....PSVS...Q.V.TLMEEQQ
  619-  676 (63.51/17.75)	NLMTMRASGAPNQQL....PV..TGAPPNQV..TQ..GGQAPP..Q..GAMlrlpnPGANPqLR.S.LLLSQQQ
  678-  709 (39.96/ 8.00)	QGGVGHMQGMM.PHQ....GL..GGQLVHPT...........PGAG..PQM.....Q.................
  711-  742 (36.08/ 6.39)	...........QWRQ....PL..AGQMMM....AA..GQRGPGAQP..PGM.....PQVSS.V...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.85|      39|      55|      46|     100|       2
---------------------------------------------------------------------------
   38-   82 (57.36/66.34)	LPAIEYfnGGppAET.DFGGDygGTQYGLVVFNTVDCAPESYVQCH
   95-  136 (56.49/27.11)	IDSIQFmgGG..AEScSLIAE..GLSVALQLFDDFKKMREQIGQTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.54|      44|      74|     431|     478|       3
---------------------------------------------------------------------------
  431-  478 (67.28/55.08)	RSL.....................PCQVQVNQgeNLNADQwpQKLIMQLIPQQ...LLTTLGPLFRNSRMVQ
  487-  554 (59.26/35.07)	ESLkglyrimatgfagcvhfphsaPCEVRVLM..LLYSSK..KRIFMGLIPNDqsgFVNGIRQVITNHKQVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12035 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLTQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPTANQQTPPSSQPGMPGVSAAQANPIGGQQQ
2) KQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVV
3) SVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVME
229
551
604
400
599
744










Molecular Recognition Features






MoRF SequenceStartStop




NANANA