<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12033

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMDLPIKPGANQVADVVFVIEGTANLGPYFESLRKHYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVSPRKLPALRALFDRASPVGGPVDPHPDYSQDPFHMILVRGISLPVSSGGGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLPQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPIANQQTPPSSQPGMPGVSAAQANPIGGQQQGVANKIVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVNQGENLNADQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMATGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVVVGMPSVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVMEDEILMDLI
Length753
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.05
Grand average of hydropathy-0.296
Instability index53.58
Isoelectric point8.49
Molecular weight80333.98
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12033
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     514.59|      82|      84|     223|     304|       1
---------------------------------------------------------------------------
  223-  304 (151.41/43.01)	LPVSSGGGSGP.LKPILPPQPLPVSQPP.......................LG.PASQAPPPISTA....HPYQP..P.....PSL........NAAQA....A.AQMAVEAA....................NNQ..K....SRFPGMV...............NPG......PPFS
  309-  396 (101.32/26.26)	LPSVAGVKLAPsSQPSLS.TVTTVSTPM.......................L..PQQQAPPP..QQ....QQVQP..P...gqPQP........NQQQP...vP.PQQQQPIA....................NQQtpP....SSQPGM.................PGvsaaqaNPIG
  419-  555 (69.40/15.59)	PKASSMDSNTK.LTRSLPCQ.VQVNQGEnlnadqwpqklimqlipqqllttLG.PLFRNSRMVQFL....FTNKD..V.....ESL........KGLYR....I...MATGFAgcvhfphsapcevrvlmllySSK..K....RIFMGLIpndqsgfvngirqviTNH......KQVQ
  556-  654 (95.16/24.21)	QHRSLGSG.GP.M.PGPPGQVQP.NQNF.......................LNrP..QGPIPVSHG....NVQQQ..SvvvgmPSVsqvtlmeeQQRQA....NlMTMRASGA....................PNQ..QlpvtGAPPNQV...............TQG...gqaPPQG
  659-  738 (97.30/24.92)	LP..NPGANPQ.LRSLLLSQQQP..QGG.......................VG.HMQGMMPHQGLGgqlvHP.TPgaG.....PQM........QA.QWrqplA.GQMMMAAG..............................QRGPGAQ...............PPG......MP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.85|      39|      55|      46|     100|       2
---------------------------------------------------------------------------
   38-   82 (57.36/63.72)	LPAIEYfnGGppAET.DFGGDygGTQYGLVVFNTVDCAPESYVQCH
   95-  136 (56.49/26.02)	IDSIQFmgGG..AEScSLIAE..GLSVALQLFDDFKKMREQIGQTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.24|      15|     328|     175|     200|       3
---------------------------------------------------------------------------
  147-  161 (28.66/21.04)	PYLLPAVESV....SYTGC
  182-  200 (21.59/17.33)	PRKLPALRALfdraSPVGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12033 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLPQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPIANQQTPPSSQPGMPGVSAAQANPIGGQQQ
2) KQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVV
3) SVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVME
229
552
605
400
600
745










Molecular Recognition Features






MoRF SequenceStartStop




NANANA