<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12031

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMDLPIKPGANQVADVVFVIEGTANLGPYFESLRKHYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVSPRKLPALRALFDRASPVGGPVDPHPDYSQDPFHMILVRGISLPVSSGGGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLTQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPTANQQTPPSSQPGMPGVSAAQANPIGGQQQGVANKIVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVNQGENLNADQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMATGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVVVGMPSVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVMEDEILMDLI
Length753
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.05
Grand average of hydropathy-0.302
Instability index52.96
Isoelectric point8.49
Molecular weight80325.92
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12031
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.33|      30|      57|     299|     328|       2
---------------------------------------------------------------------------
  239-  273 (39.02/ 8.60)	PPQPLP.VSQPPLGPASQapPPISTAhpyqPPPSLN
  274-  304 (34.83/ 6.91)	AAQAAAQMA.VEAANNQK..SRFPGM..vnPGPPFS
  365-  396 (40.48/ 9.19)	PQQQQPT.ANQQTPPSSQ..PGMPGV.saaQANPIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     109.06|      19|      34|     592|     610|       3
---------------------------------------------------------------------------
  592-  610 (29.29/11.36)	GNVQQQSVVVGMPSVSQVT
  628-  645 (29.24/11.32)	GAPNQQLPVTGAPP.NQVT
  674-  692 (28.19/10.56)	SQQQPQGGVGHMQGMMPHQ
  729-  743 (22.35/ 6.37)	G.PGAQPP..GMPQVSSV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.07|      15|      20|     553|     567|       4
---------------------------------------------------------------------------
  553-  567 (28.61/10.59)	QVQQHRSL..GSGGPMP
  572-  588 (27.46/ 9.87)	QVQPNQNFlnRPQGPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.85|      39|      55|      46|     100|       5
---------------------------------------------------------------------------
   38-   82 (57.36/64.64)	LPAIEYfnGGppAET.DFGGDygGTQYGLVVFNTVDCAPESYVQCH
   95-  136 (56.49/26.47)	IDSIQFmgGG..AEScSLIAE..GLSVALQLFDDFKKMREQIGQTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.54|      10|      17|     306|     315|       9
---------------------------------------------------------------------------
  306-  315 (16.80/ 8.43)	QSTLPSVAGV
  322-  331 (16.73/ 8.36)	QPSLSTVTTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.17|      28|      76|     432|     463|      10
---------------------------------------------------------------------------
  432-  463 (39.64/47.73)	RSLPCQVQVNQgeNLNADQwpQKLIMQLIPQQ
  509-  536 (48.52/37.28)	HSAPCEVRVLM..LLYSSK..KRIFMGLIPND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12031 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSGPLKPILPPQPLPVSQPPLGPASQAPPPISTAHPYQPPPSLNAAQAAAQMAVEAANNQKSRFPGMVNPGPPFSGQSTLPSVAGVKLAPSSQPSLSTVTTVSTPMLTQQQAPPPQQQQVQPPGQPQPNQQQPVPPQQQQPTANQQTPPSSQPGMPGVSAAQANPIGGQQQ
2) KQVQQHRSLGSGGPMPGPPGQVQPNQNFLNRPQGPIPVSHGNVQQQSVV
3) SVSQVTLMEEQQRQANLMTMRASGAPNQQLPVTGAPPNQVTQGGQAPPQGAMLRLPNPGANPQLRSLLLSQQQPQGGVGHMQGMMPHQGLGGQLVHPTPGAGPQMQAQWRQPLAGQMMMAAGQRGPGAQPPGMPQVSSVME
229
552
605
400
600
745










Molecular Recognition Features






MoRF SequenceStartStop




NANANA