<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12030

Description mediator of RNA polymerase II transcription subunit 26-like isoform X1
SequenceMTTASATPQQMRDRLLQAIDSHSNQICNMVAVLEVITYLEKFPITKEALEETRLGKLINDVRKQTKDEDLAKRAKKLLRSWQKLIEPGQNETPSRGAVCVPGSANGSAHPCRTDIPPPDVSMASKGVPEVKTRNDVHNIHSPKAEKSSSRKRRGEQRDSVHLTDKISNLSPYEQMYNTPPPTNGIAGSPEAPPSPDRARTEHLENDKHSRIPVNAVKPHPSSPGLTKLPSTSSLLKTAVLQQQARLDEGGGGQYQAKSPHCLSSSLRSPRTMKQETMSKRSSTFAPKGNIPSPARSPRLLSSQSLKSPSLKSLAEVSHVDGLPPPAHRASLHWPGSSEVTTHPPRNAATLEPPPVFPPTSQPAPTNSESSELQRPTPSSSVVVVKAEAEVAASSSDRKKRKKYRSRDYSVNLQGQDTEDQTRPVRLKERRLTFDPVTGQIKSMVHKEPSQVEGPPRPPPPEPQQRTHLPLQQHPAPTPSPFQQTNWKELSRNDIIQSYLNLQSNVLTSSGVQAPGAHFFMSEYLKREESDVREARRGVHVLQLDSSVTDTPGVSREVTDEDLHRVHMEHWQGVNGCCDTKGTWYDWTECISLDPHGDESKLNILPYVCLD
Length610
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.04
Grand average of hydropathy-0.845
Instability index68.40
Isoelectric point9.05
Molecular weight67453.93
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12030
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     321.27|      45|     110|     323|     367|       1
---------------------------------------------------------------------------
   93-  134 (49.23/17.95)	..PS.RG...AVCVPG.SANGSAH........PCR....TDIPP............P....DVS......M.ASK.GVPevkTRN
  142-  195 (44.11/15.29)	PKAEKSS...SRKRRG.EQRDSVHltdkisnlSPY.EQMYNTPP............PtngiAGS......P.EAP.PSP......
  196-  233 (35.70/10.91)	....DRArteHLENDK.HSRI............PV.NA..VKPH............P....SSP......G.LTK.LPS...TSS
  238-  296 (42.46/14.43)	AVLQQQA...RLDEGG.GGQYQAK........SPHcLSSSLRSPrtmkqetmskrsS....TFA......P.KGNiPSP...ARS
  323-  367 (85.30/36.70)	PPPAHRA...SLHWPG.SSEVTTH........PPR.NAATLEPP............P....VFP......P.TSQ.PAP...TNS
  399-  439 (26.39/ 6.08)	KRKKYRSrdySVNLQGqDTEDQTR........PVR....LKERR............L....TFD......PvTGQ..........
  442-  479 (38.08/12.15)	..........SMVHKE.PSQV.EG........PPR.......PP............P....PEPqqrthlP.LQQhPAP...TPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.95|      24|      26|     527|     552|       2
---------------------------------------------------------------------------
  527-  552 (32.91/27.23)	EESDvREARRgVHV..LQLDSSVTDTPG
  556-  581 (41.05/23.99)	EVTD.EDLHR.VHMehWQGVNGCCDTKG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12030 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) WQKLIEPGQNETPSRGAVCVPGSANGSAHPCRTDIPPPDVSMASKGVPEVKTRNDVHNIHSPKAEKSSSRKRRGEQRDSVHLTDKISNLSPYEQMYNTPPPTNGIAGSPEAPPSPDRARTEHLENDKHSRIPVNAVKPHPSSPGLTKLPSTSSLLKTAVLQQQARLDEGGGGQYQAKSPHCLSSSLRSPRTMKQETMSKRSSTFAPKGNIPSPARSPRLLSSQSLKSPSLKSLAEVSHVDGLPPPAHRASLHWPGSSEVTTHPPRNAATLEPPPVFPPTSQPAPTNSESSELQRPTPSSSVVVVKAEAEVAASSSDRKKRKKYRSRDYSVNLQGQDTEDQTRPVRLKERRLTFDPVTGQIKSMVHKEPSQVEGPPRPPPPEPQQRTHLPLQQHPAPTPSPFQQTNWK
81
487










Molecular Recognition Features






MoRF SequenceStartStop




NANANA