<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12025
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MVGSKSFISDLHSKYAEKTWNETFKLVRRCMDKSRGDTKPCEPLIRCLKILHESLNVLSLSAMASRLEIIAKQRGMGSHLSPTETTCYLTADMFYLEVLLLPGGEVEDVKLAQHGEAPVSSESLLQLLKSKKFEEFSVKLKGLSSLYNIPGDNETKIKVYTALQFLGKDLQKISHLPRALREYNLQVDMILNGRIGYLLAGSEGIPMTIQYYISPSDILLMSDSERCSVGQLALVTVGPTDCTHKLQMASVIPQPPQLDAQGLPLFSPLCEVLSGMMPACFQLKLQPPLPMLSSFVEKLSQITDVAIADTDLQWAPFPQLMMTLRENGGDKTWDGQDAHFLVPLPGREMHSYVLPGAAWEEAALRGALVSTIPFTHPAHVPALLELLRHQCAINTLLASCITSHRPSPGPVCDLYCEVLPESGSSLSVTFHLSDSDSLSVLLVNVADSQKLTCSLFAVRSEDQSMDEYVSRVLKRCMSIPVTMRALNRRLSKRTCGEPLPACSSTVSTADGSPASPPLPMSCEADSQKRDCPGLESIGIPTTPSTAAMFSQDAMGPDATPMEAESAFCLSVTEVNTNPTVNPYPSASVCVYSHWMHNNHLPEFI |
Length | 604 |
Position | Middle |
Organism | Salmo salar (Atlantic salmon) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes>
Salmonidae> Salmoninae> Salmo.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.042 |
Instability index | 53.45 |
Isoelectric point | 5.56 |
Molecular weight | 66091.58 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12025
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.12| 18| 26| 252| 274| 1
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262- 284 (23.43/15.86) GLPLfspLCEVLSgmMPACFQLK
517- 535 (30.69/ 8.88) PLPM...SCEADS.qKRDCPGLE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.80| 21| 26| 361| 381| 2
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361- 381 (36.63/17.98) EAALRGALVSTIPFTHPAHVP
390- 410 (39.17/19.65) QCAINTLLASCITSHRPSPGP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.03| 12| 24| 556| 568| 5
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556- 568 (18.37/12.82) PDATPMEAESAfC
578- 589 (23.66/11.68) PTVNPYPSASV.C
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 152.02| 42| 257| 212| 256| 7
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212- 256 (68.80/47.47) YISPsdILlMSDSERC...SVGQLAL......VTVGP..TDCTHKL..QMASVIPQPP
432- 463 (33.24/14.20) .........LSDSDSL...SV...LL......VNV....AD.SQKLtcSLFAVRSEDQ
468- 516 (49.98/25.87) YVSR..VL.....KRCmsiPVTMRALnrrlskRTCGEplPACSSTV..STADGSPASP
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