<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12024
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MGSHLSPTETTCYLTADMFYLEVLLLPGGEVEDVKLAQHGEAPVSSESLLQLLKSKKFEEFSVKLKGLSSLYNIPGDNETKIKVYTALQFLGKDLQKISHLPRALREYNLQVDMILNGRIGYLLAGSEGIPMTIQYYISPSDILLMSDSERCSVGQLALVTVGPTDCTHKLQMASVIPQPPQLDAQGLPLFSPLCEVLSGMMPACFQLKLQPPLPMLSSFVEKLSQITDVAIADTDLQWAPFPQLMMTLRENGGDKTWDGQDAHFLVPLPGREMHSYVLPGAAWEEAALRGALVSTIPFTHPAHVPALLELLRHQCAINTLLASCITSHRPSPGPVCDLYCEVLPESGSSLSVTFHLSDSDSLSVLLVNVADSQKLTCSLFAVRSEDQSMDEYVSRVLKRCMSIPVTMRALNRRLSKRTCGEPLPACSSTVSTADGSPASPPLPMSCEADSQKRDCPGLESIGIPTTPSTAAMFSQDAMGPDATPMEAESAFCLSVTEVNTNPTVNPYPSASVCVYSHWMHNNHLPEFI |
Length | 529 |
Position | Middle |
Organism | Salmo salar (Atlantic salmon) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes>
Salmonidae> Salmoninae> Salmo.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.003 |
Instability index | 56.03 |
Isoelectric point | 5.05 |
Molecular weight | 57542.59 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12024
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.12| 18| 26| 177| 199| 1
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187- 209 (23.43/19.06) GLPLfspLCEVLSgmMPACFQLK
442- 460 (30.69/10.65) PLPM...SCEADS.qKRDCPGLE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.80| 21| 26| 286| 306| 2
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286- 306 (36.63/19.17) EAALRGALVSTIPFTHPAHVP
315- 335 (39.17/20.94) QCAINTLLASCITSHRPSPGP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.03| 12| 24| 481| 493| 5
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481- 493 (18.37/13.57) PDATPMEAESAfC
503- 514 (23.66/12.39) PTVNPYPSASV.C
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 152.02| 42| 257| 137| 181| 7
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137- 181 (68.80/52.36) YISPsdILlMSDSERC...SVGQLAL......VTVGP..TDCTHKL..QMASVIPQPP
357- 388 (33.24/15.69) .........LSDSDSL...SV...LL......VNV....AD.SQKLtcSLFAVRSEDQ
393- 441 (49.98/28.55) YVSR..VL.....KRCmsiPVTMRALnrrlskRTCGEplPACSSTV..STADGSPASP
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