<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12020

Description mediator of RNA polymerase II transcription subunit 14-like
SequenceMAPVQIGSDGQLVPIGGPTSATQPPSSGPQAAQGVRLSLLIEFLLQRTYHEITLLGELLPRKTDMERKIEIVQFSSRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKVEKQTTLNQLNQILRHRLVTTDLPPQLANLTVVNGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDCRALVHSMQVNFIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLYRERWGDLVQVEHYMPAKCLTLAVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHDPPLPACDSRLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKNSNPSDSSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFHPMLYGIDQSMLDDIEKTINDDMKRIISWLQQLKFWLGEQRCRQSVKHLPTICTDILHLSNSASHPASSLSKHRLFIRLTRLPQYYIVVEMLDMPGCPTELQYKYSFLSVSQLEGEEGPPCAQLLQQFKPNLEQLVLDNSAGQGARPGAKRKLSGDQGALEPKKPKRSGEMSAFNKELAHLVAMCDTNMPFISLRVELSQMEIPHQGVQVEGDGCSHAIRILKIPPSKGVGEETSLALERSLLDCTFRLQGRNNRTWVAELILANCPLNSTHSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWISINQLYQCVLVFSRSLPEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSSSQRFHLSLGTVGPNSGCSNCHNIILHQLQEMFNKTPTVVPLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSATHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGGDMMDTFMSQLQAQQQQPMRVGPGGVYPPLTSPPTPYHPNVPTQSPGALDPSSPYAMVSPNQRGQWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRASSSSGSMPSSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLSIVNSNEPGVIMFKTEVLKCRVALNPKTYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPLPQEPVNIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFSELHPARQGECTIFASVHELMANLNLTPGGRQ
Length1386
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.06
Grand average of hydropathy-0.169
Instability index51.89
Isoelectric point8.56
Molecular weight154258.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12020
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.73|      19|      19|    1034|    1052|       1
---------------------------------------------------------------------------
  998- 1011 (23.48/ 8.12)	.PG....GVYP..PLTSPPTP
 1013- 1029 (27.23/10.76)	HPNVP..TQSPGALDPSSP..
 1034- 1052 (39.33/19.27)	SPNQR..GQWPGSPQVSGPSP
 1054- 1071 (20.68/ 6.15)	...ARihGMSPGNPSLHSPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.69|      13|      19|     653|     671|       2
---------------------------------------------------------------------------
  653-  668 (21.91/25.28)	PHQGVqveGDGCSHAI
  675-  687 (22.78/ 8.05)	PSKGV...GEETSLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.79|      21|     149|     281|     302|       3
---------------------------------------------------------------------------
  281-  302 (36.37/28.38)	CLHSFCLSLQLEvLHSQTL..MLY
  432-  454 (38.42/25.07)	CGRSECLHIFVD.LHSGMFhpMLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.55|      15|      19|     853|     871|       4
---------------------------------------------------------------------------
  854-  868 (23.64/ 8.84)	LLQVLSDTQAPLNAI
 1302- 1316 (25.91/ 7.87)	LTQRLPLPQEPVNII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.46|      15|     447|      76|      91|       5
---------------------------------------------------------------------------
   76-   91 (22.29/19.67)	SRTRqLFVRLLALVKW
  520-  534 (28.17/19.34)	SKHR.LFIRLTRLPQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.56|      11|      19|    1214|    1226|       7
---------------------------------------------------------------------------
 1214- 1226 (16.01/12.85)	LEKFfeTRVAGPP
 1232- 1242 (19.55/ 8.76)	LNAF..TKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      12|      19|     807|     818|       8
---------------------------------------------------------------------------
  807-  818 (23.59/14.67)	TIQWNSSSQRFH
  823-  834 (24.48/15.52)	TVGPNSGCSNCH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     261.03|      57|      78|     460|     516|       9
---------------------------------------------------------------------------
  326-  366 (39.23/16.68)	......................WN..QQV...LGRK..TGTASV....HK.VTIKIDEsdgskpLQISHDPPLPA
  376-  431 (51.12/23.84)	MkIDhlSVEKLLIDSVHaRSHQKL..QELKAILKNS..NPSDSSfieTAL.PTLVIPI......LE.......P.
  460-  516 (104.21/55.81)	M.LD..DIEKTINDDMK.RIISWL..QQLKFWLGEQ..RCRQSV...KHL.PTICTDI......LHLSNSASHPA
  540-  594 (66.46/33.08)	M.LD....MPGCPTELQ.YKYSFLsvSQLE...GEEgpPCAQLL...QQFkPNL..EQ......LVLDNSAGQGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.06|      58|      71|      97|     156|      13
---------------------------------------------------------------------------
   97-  156 (87.95/76.73)	KVEKCAMISSfLDQQAFLFVDTADRLASLARDALVHARLpSFAI..PFAIDVLTTGSYPRLP
  171-  230 (93.11/69.46)	KVEKQTTLNQ.LNQILRHRLVTTDLPPQLANLTVVNGRV.KFRVegEFEATLTVMGDDPDIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12020 with Med14 domain of Kingdom Metazoa
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