<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12014

Description mediator of RNA polymerase II transcription subunit 14-like isoform X2
SequenceMAPVQIGSDGQLVPIGGPTSATQPPPTGPPATEGVRLSLLIEFLLQRTYHEITLLGELLPRKTDMERKIEIVQFSSRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKVEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNFIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLVRERWGDLVQVERYMPAKCLTLAVWNQQVLGRKTGTASVHKVTIKIDESDCSKPLQISHDPPLPACDSRLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPSDSSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSILDDIEKTINDDMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTDILHLSNSISHPAGSLSKHRLFIRLTRLPQYYIVVEMLDVPGCPTELQYKYSFLSVSQLEGEEGPPCAQLLQHFKPNLEQLVLDNCASRGARHGAKRKLSGDQGALEPKKPKRSGEMSAFNKELAHLVAMCDTNMPFIGLRVELSQMEIPHQGVQVEGDGCSHAIRILKIPPSKGVGEETRQALERSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWSAISQLYQCVLVFSRSLPEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSSTQRFHLSLGTVGPNSGCSNCHNIILHQLQEMFNKTPTVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGGDIMDTLMSQFQAQQQQQTMRGGPGGVYPPLTSPPTPYHPNVAPSPSMMPTQSPGALDPSSPYAMVSPSQRGQWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRTGSSSGAMPSSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLSIVNSNEPGVIMFKTEVLKCRVALNPKTYQTLQLKVTPENAGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPVPQEPVNIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHELMANLNLPPGGRQ
Length1394
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.06
Grand average of hydropathy-0.173
Instability index52.66
Isoelectric point8.64
Molecular weight154996.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12014
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.39|      18|      18|    1020|    1037|       1
---------------------------------------------------------------------------
 1020- 1037 (35.80/16.92)	SP.SMMPT..QSPGALDPS..SP
 1042- 1058 (31.11/13.57)	SP.SQR.G..QWPGSPQVS..GP
 1059- 1077 (20.97/ 6.34)	SPgARIHG..MSPG..NPSlhSP
 1080- 1099 (22.52/ 7.44)	DA.SHSPRtgSSSGAMPSS..MP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.52|      27|     651|       4|      58|       2
---------------------------------------------------------------------------
   18-   47 (45.08/33.79)	PTSAtqpPPTGPPATEGVRLSLLIEFLLQR
 1284- 1310 (50.44/12.80)	PPSA...PPIAPPGTIAVVLKSKMLFFLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     312.43|      70|      78|     448|     524|       3
---------------------------------------------------------------------------
  326-  371 (36.04/10.20)	............................WN..QQV...LGRK..TGTASV....HK.VTIkidesdCSKPLQ....ISHdpplPA...CDSRL
  372-  440 (69.31/37.10)	..MERAMkIDhlSVEKLLIDSVHaRSHQKL..QELKAILKSS..NPSDSSfieTAL.PTL......VIPILE...........PCGRSECLHI
  454-  524 (119.95/63.70)	YgIDQSI.LD..DIEKTINDDMK.RIISWL..QQLKFWLGEQ..RCRQSV...KHL.PTV......CTDILHLSNSISH....PAGSLSKHRL
  535-  602 (87.14/40.50)	Y.IVVEM.L...DVPGC.PTELQ.YKYSFLsvSQLE...GEEgpPCAQLL...QHFkPNL........EQLVLDNCASR....GARHGAKRKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     242.34|      60|      72|      97|     156|       4
---------------------------------------------------------------------------
   97-  156 (96.57/51.98)	KVEKCAMISSFLDQQAFLFVDTADRLASLARD.ALVHARLPSFAI..PFAIDVLTTGSYPRLP
  171-  230 (83.20/43.85)	KVEKQTTLNQ.LNQILRHRLVTTDLPPQLANL.TVANGRV.KFRVegEFEATLTVMGDDPDIP
  245-  294 (62.57/31.31)	TGDGRALVHSM..QVNFIHELVQSRLFADEKPlQDMYSCLHSFCL..SLQLEVL.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.13|      27|     280|     925|     952|       8
---------------------------------------------------------------------------
  925-  952 (45.27/40.47)	GAYSLfDNTKIVEGFY....PAPGLK.TFLNMF
 1212- 1243 (40.85/29.73)	GPWSQ.EELQVLEKFFetrvAGPPFKyNTLNAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.95|      16|      19|     653|     671|      10
---------------------------------------------------------------------------
  653-  671 (26.37/25.63)	PHQGVqveGDGCSHAI.RIL
  675-  691 (23.58/13.80)	PSKGV...GEETRQALeRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.33|      21|     108|     702|     722|      13
---------------------------------------------------------------------------
  693-  713 (33.98/23.47)	DCTFRLQGRNNRTWVAELVLA
  714-  734 (35.35/24.74)	NCPLNSTHSKEQASTRHVYLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12014 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPVGGDIMDTLMSQFQAQQQQQTMRGGPGGVYPPLTSPPTPYHPNVAPSPSMMPTQSPGALDPSSPYAMVSPSQRGQWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRTGSSSGAMPSSMPPPRKLPQRSWA
956
1110










Molecular Recognition Features






MoRF SequenceStartStop




NANANA