<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12013

Description mediator of RNA polymerase II transcription subunit 14-like isoform X1
SequenceMAPVQIGSDGQLVPIGGPTSATQPPPTGPPATEGVRLSLLIEFLLQRTYHEITLLGELLPRKTDMERKIEIVQFSSRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKVEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNFIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLVRERWGDLVQVERYMPAKCLTLAVWNQQVLGRKTGTASVHKVTIKIDESDCSKPLQISHDPPLPACDSRLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPSDSSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSILDDIEKTINDDMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTDILHLSNSISHPAGSLSKHRLFIRLTRLPQYYIVVEMLDVPGCPTELQYKYSFLSVSQLEGEEGPPCAQLLQHFKPNLEQLVLDNCASRGARHGAKRKLSGDQGALEPKKPKRSGEMSAFNKELAHLVAMCDTNMPFIGLRVELSQMEIPHQGVQVEGDGCSHAIRILKIPPSKGVGEETRQALERSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWSAISQLYQCVLVFSRSLPEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSSTQRFHLSLGTVGPNSGCSNCHNIILHQLQEMFNKTPTVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGGDIMDTLMSQFQAQQQQQTMRGGPGGVYPPLTSPPTPYHPNVAPSPSMMPTQSPGTIHASGSPSGALRAPSPFGPTPSPSSLGIAMGPTSFASPHGALDPSSPYAMVSPSQRGQWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRTGSSSGAMPSSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLSIVNSNEPGVIMFKTEVLKCRVALNPKTYQTLQLKVTPENAGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPVPQEPVNIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHELMANLNLPPGGRQ
Length1435
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.06
Grand average of hydropathy-0.169
Instability index53.58
Isoelectric point8.68
Molecular weight158866.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12013
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     197.20|      29|      29|    1034|    1062|       1
---------------------------------------------------------------------------
  997- 1028 (31.95/10.50)	..GGPGGVypplTSPPTPYHPNvaPSPSMM.P.TQS
 1034- 1062 (51.89/21.95)	ASGSPSGA....LRAPSPFGPT..PSPSSL.GIAMG
 1067- 1092 (42.05/16.30)	..ASPHGA....LDPSSPYAMV...SPSQR.GQWPG
 1128- 1154 (37.68/13.79)	.TGSSSGA....MPSSMP.PPR..KLPQRS.WAASI
 1155- 1181 (33.63/11.46)	PTILTHNA....LHV..LLLPS..PTPCLVpGLA.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.57|      26|      29|    1314|    1339|       2
---------------------------------------------------------------------------
 1314- 1339 (49.89/20.77)	LKWNVQFCLTIPPSAPPIAPPGTIAV
 1341- 1366 (41.68/16.25)	LKSKMLFFLQLTQRLPVPQEPVNIIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.26|      17|      29|     752|     769|       3
---------------------------------------------------------------------------
  752-  769 (28.53/22.71)	FLNDWSAIsQLY...QCVLVF
  779-  798 (25.73/15.10)	YLSLFSEI.RLYnyrKLVLCY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.97|      24|      29|     238|     266|       4
---------------------------------------------------------------------------
  238-  261 (40.53/29.51)	ILVEDKETGDGRALVH....SMQVNFIH
  268-  295 (36.44/15.89)	LFADEKPLQDMYSCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.13|      12|      14|     807|     818|       7
---------------------------------------------------------------------------
  807-  818 (23.68/14.06)	TIQWNSSTQRFH
  823-  834 (24.45/14.78)	TVGPNSGCSNCH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.64|      14|      29|     154|     167|       9
---------------------------------------------------------------------------
  154-  167 (25.79/11.00)	RLPTCIRDKIIPPD
  180-  193 (22.85/ 9.10)	QLNQILRHRLVTTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.44|      13|      30|      71|      83|      10
---------------------------------------------------------------------------
   71-   83 (22.17/14.14)	IVQFSSRTRQLFV
  104-  116 (22.26/14.23)	ISSFLDQQAFLFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.71|      38|     125|     583|     620|      11
---------------------------------------------------------------------------
  583-  620 (65.57/44.58)	QLVLDNC...ASRGARHGAKRK..LSGDQGALEPKKPKRSGEM
  709-  751 (55.13/36.15)	ELVLANCplnSTHSKEQASTRHvyLTYENPLSEPVGGRKVVEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.48|      10|      17|    1094|    1103|      12
---------------------------------------------------------------------------
 1094- 1103 (19.75/ 8.53)	PQVSGPSPGA
 1113- 1122 (19.73/ 8.51)	PSLHSPIPDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.18|      18|      21|     837|     855|      14
---------------------------------------------------------------------------
  837-  855 (27.86/22.66)	ILHQLQ...EMFNKTPTvVQLL
  857-  877 (26.32/15.92)	VLSDTQaplNAINKLPT.VPML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.56|      11|      17|    1263|    1275|      15
---------------------------------------------------------------------------
 1263- 1275 (16.01/18.05)	LEKFfeTRVAGPP
 1281- 1291 (19.55/12.38)	LNAF..TKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.95|      16|      19|     653|     671|      16
---------------------------------------------------------------------------
  653-  671 (26.37/22.67)	PHQGVqveGDGCSHAI.RIL
  675-  691 (23.58/12.06)	PSKGV...GEETRQALeRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.64|      17|      21|     427|     444|      19
---------------------------------------------------------------------------
  405-  421 (26.33/11.33)	ILKSSNPSDSSFIETAL
  428-  444 (30.31/21.55)	ILEPCGRSECLHIFVDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12013 with Med14 domain of Kingdom Metazoa
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