<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12012

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWRRFVWQGPTSSPILFPVTEEDPILCSFSRCLAADVLSVWRRHHTPGRRELWLFWWGDDPSFAELIHHDLSSEEEGEWESGLSYECRTLLFKAVHNLLERCLMNRSFVRIGKWFVKPYEKDEKPISKSEHLSCAFTFFLHGDSNVCTSVEIAQHQSVQRLSEEHLSLALQNASPLQVILSPYGLNGTVTGQSFKMSDHPTQKLIEEWRQFYPISPSAKDRSEDKMKDADWEDDSLAAVEVLVAGVRMVYPACLVLVPQSDLPALAPQGSANPSAILCEGQGAHRDPAMSSVTLTPPTSPEEAQTDHQAAQRWLKLCLTVDGFSSNSSGIHGSKIPRRLAAQVVESVWQECTTNRAQSKRKFATLTNGTCEEEEEEGDKTGVWDFVESSHRAHCNCSRHKNQKQRSGSTSGNPPSVGKPPQPPPKHKLGEKLEKGEKQQKRPQTPFHHRSYVFEEQAMEPRRLCMRTQDEGPYPSLHHIDTAPSKAPMLHTHGTPQDLAGSPQPPPLSPHPCEHGEEDPGAMKSSSTPIHQHFYPPSSEPCLLPQKTSSDLPLPFPPAYPESLEPTAYVGSAINPNEDSAHNPWKYFNLPRKKASDFLTPLLPVDKLQDDSGGGGGQENIVSVTELMSGSGRPLKVSDDLVRTYTQRRNSHLAAAMADEDQEEEPDPYAFVEGDEEFTFTDKKDKPGSERETSKRHKGDDGSGTSADDGQGAAGKPIPSTSLIHETDLAVSINDLDNLFNSDEDELAPGSRRAGVHGDKFGSKEHKTSNLDPLSCISSADLHKMFPTPPSLEQHIMGYSPMNTGGKDYGGLEGGLGLTLLDGSQFSSHYKMEVEEGFCSPKPSEIKDFSFVYKSEACKAFTGCSMFAPLKMLPSQCMMPIKLPEDCVYTPSWTMGKLELIPPVPSMGLLTKDGNIPSVEPDYQSYTPQTHTPFMSNSAPPSNSGMGILPSPATPRFSAPTPRTPRTPRTPRGPASVQGSLKYENSDLYSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCVCVCNMNIRGADVGVYLNDNGEAQYPCTCGFSAVVNRRYGSSAGLFLEDELDVVGRDSDAGRDSERRFQERHAASLHRTGNPKERPPDELILLLQDQCTNPFSPMAGVEYPRALSSGPSRSSLRVEERDCYNDCYMALEHGRQFMDNMSGGKVDEALVKSTCLHNWPKRKAAEVSRLFSQDVLRVLLSLQPVLQDAIQKKRSIRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSHRDVGYVVVCPENEALLRGAKSFFKDLTAVYEACRLGQHRPICKTHADGILRVGTAEGRNLAEQPLSDWFLKMASSNGNSEAFSKLKLYAQVCRHDLAPYLAEQSLDSSLLNQRSPTVASPQSSSSQSPCSTTPSSGPQNSTSSSTGQPTNSTPPSSTIGTQAVGGIGGVGMPSAKPSSYTPYGTSGLQGSVSQNGPQSGAQTTGENGPTANQPQATTEPVETTLEREKVGVPTDGESHAVTFPPAIVVYIVDPFSYEDGERDTHSSVWTLGLLRCYVEMLQFLPSHIRNSVSVQIIPCQYLLQPVRIDERHLYGQHLKSLAFSVFTQCRRPLPSNTNIKALTGFGPGLAIDMALRSSERPECLRLYTPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDQSGELLETCIISIDVPNRARRKKGSARRLGLQKLWEWCLGLVQVTSLPWRVVIGRLGRMGHGELRDWSILLSRRNLQSLSKRLKETCRMCGISAADTPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAMVQVNNATTEQNLDIAFNPINPDGSDGMGIFDLFDNDMVDPDLINILPNSPTTSPVHSPGGHYHQGGDGSKGQSTDRMESHEEALNILQQPMALGYLISTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQSDELLHSKHSHPLDSNHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQMYNFIMNML
Length2114
PositionMiddle
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.07
Grand average of hydropathy-0.460
Instability index59.75
Isoelectric point5.69
Molecular weight232538.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12012
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     498.41|     138|     148|     773|     914|       1
---------------------------------------------------------------------------
  444-  568 (131.13/58.77)	VGKPPQPPPKHKLGeKLEKGEKQQKRPQTPF.HHRSYVFEEQ.AMEP..R..........................................................rlcmrtqdegpypslhhidtapskAPMLHTHGTPQDLAGSP..QPPPLSPHPCehgeedpgamkSSSTPIHQHF....YPPSSEP..
  773-  823 (49.46/16.12)	..........................................................................................................EL........................APGSRRAGVHGDKFGSKEHKTSNLDPLSC...........ISSADLHKMF...PTPPSLEQHI
  824-  972 (204.66/105.65)	MGYSPMNTGGKDYG.GLEGGLGLTLLDGSQFSSHYKMEVEEG.FCSP..KPSEIKDFSFVYKSEACKAFTGCSMFAPLKMlpSQCMMpiKLPEDCvytpswtmgklEL........................IPPVPSMGLL.....TKDGNIPSVEPDYQ...........SYTPQTHTPFmsnSAPPS..NSG
  973- 1062 (113.16/49.56)	MGILPSPATPRFSA.PTPRTPRTPRTPRGPASVQGSLKYENSdLYSPasTPSTCRPLSSVEPATVPSIPEAHSLYVTLIL..SESVM..NLFKDC....................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     348.04|     107|     149|      72|     188|       2
---------------------------------------------------------------------------
   72-  188 (172.01/138.12)	HHTPGRRELWLFWWGDDPSfAELIHHDlsSEEEGEWESGlSYECRTLLFKAVHNLLERCLMnrsFVRIGKWFVKPYEKDEKPIS.....KSEHLSCAFTFFLHGDSnvcTSVEIAQ..HQSVQR
  227-  340 (176.03/111.39)	HPTQKLIEEWRQFYPISPS.AKDRSED..KMKDADWEDD.SLAAVEVLVAGVRMVYPACLV...LVPQSDLPALAPQGSANPSAilcegQGAHRDPAMSSVTLTPP...TSPEEAQtdHQAAQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.81|      18|      22|    1378|    1399|       6
---------------------------------------------------------------------------
 1378- 1399 (25.06/26.85)	PIckthADGILRVGTAEGRNLA
 1402- 1419 (30.75/18.99)	PL....SDWFLKMASSNGNSEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.47|      27|     409|     698|     724|       7
---------------------------------------------------------------------------
  698-  724 (47.03/29.27)	FVEGDEEFTFTDKKDKPGSERE....TSKRH
  726-  752 (26.69/13.02)	...GDDG.SGTSADDGQGAAGKpipsTSLIH
 1114- 1140 (43.74/26.64)	FLEDELDVVGRDSDAGRDSERR....FQERH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.81|      21|     146|    1150|    1189|       8
---------------------------------------------------------------------------
 1092- 1112 (41.26/19.37)	QYPCTCGFSAVVNRRY......GSSAG
 1163- 1189 (35.56/17.55)	QDQCTNPFSPMAGVEYpralssGPSRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.40|       9|      21|    1484|    1494|       9
---------------------------------------------------------------------------
 1484- 1494 (14.68/11.23)	GQPtnSTPPSS
 1508- 1516 (18.71/ 7.48)	GMP..SAKPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.95|      84|     154|    1636|    1725|      15
---------------------------------------------------------------------------
 1636- 1725 (132.14/88.93)	CQYLLQPVRIDERHLYGQ.....HLKSLAFSVFTQcRRPLPSNTniKALTGFGPGLAIDMALRSSERPECLRLYTP..PFILAPikDkQTELGETFG
 1791- 1881 (137.81/74.50)	CLGLVQVTSLPWRVVIGRlgrmgHGELRDWSILLS.RRNLQSLS..KRLKETCRMCGISAADTPSILSACLVAMEPqgSFVIMP..D.SVSTGSVFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.69|      38|     996|     572|     612|      16
---------------------------------------------------------------------------
  572-  612 (61.58/39.77)	PQKTSSDLPLPFPPAypESLEPTAYvGSAINPNEDSAHNPW
  618-  655 (64.11/31.58)	PRKKASDFLTPLLPV..DKLQDDSG.GGGGQENIVSVTELM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.08|      11|      22|    1547|    1557|      19
---------------------------------------------------------------------------
 1547- 1557 (19.95/12.85)	TANQPQATTEP
 1571- 1581 (20.14/13.06)	TDGESHAVTFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.58|      11|      37|      21|      32|      20
---------------------------------------------------------------------------
   21-   32 (19.18/17.75)	CLA.DLTGIkWRR
   60-   71 (18.40/10.77)	CLAaDVLSV.WRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12012 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GRPLKVSDDLVRTYTQRRNSHLAAAMADEDQEEEPDPYAFVEGDEEFTFTDKKDKPGSERETSKRHKGDDGSGTSADDGQGAAGKPIPSTSLIHET
2) HCNCSRHKNQKQRSGSTSGNPPSVGKPPQPPPKHKLGEKLEKGEKQQKRPQTPFHHRSYVFEEQAMEPRRLCMRTQDEGPYPSLHHIDTAPSKAPMLHTHGTPQDLAGSPQPPPLSPHPCEHGEEDPGAMKSSSTPIHQHFYPPSSEPCLLPQKTSSDLPLPFPPAYPESLEPTAYVGSAINP
3) INILPNSPTTSPVHSPGGHYHQGGDGSKGQSTDRMESHEEA
4) LTPLLPVDKLQDDSGGGGGQENIVSVTELMSG
5) NDLDNLFNSDEDELAPGSRRAGVHGDKFGSKE
6) PSVEPDYQSYTPQTHTPFMSNSAPPSNSGMGILPSPATPRFSAPTPRTPRTPRTPRGPASVQGSL
7) RAQSKRKFATLTNGTCEEEEEEGDKTGVWD
8) SSLLNQRSPTVASPQSSSSQSPCSTTPSSGPQNSTSSSTGQPTNSTPPSSTIGTQAVGGIGGVGMPSAKPSSYTPYGTSGLQGSVSQNGPQSGAQTTGENGPTANQPQATTEPVETTLEREKVGVPTDGE
659
421
1955
626
761
944
383
1445
754
603
1995
657
792
1008
412
1574










Molecular Recognition Features






MoRF SequenceStartStop




1) EPDPYAFVEGDE
2) KHKLGEKLEKGEKQ
3) NPWKYFNLPRKKASDFLTPLLP
692
453
610
703
466
631