<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12007

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAAVSMQGCSPNPARELALSTQSGGNQALADRVKAEEGTAEKQSRVNALLERLHAKHNASRPWQETSKVVRQAMEKRGQMNAAGHQLLLTCLETLQKALKVSSLPSMTDRLESIARQNMLGSHLSPSGTECYITSDMFYVEVQLDTAGQLVDVKVAHHGENPASCPELIQHLRDKNFEEFSKHLKGLVNLYKLPGDNKLKTKMYLALQSLELDLTKMMHMFRLATNANTVETILHGSVGLLTARSGGHLVSLQCYVSPYDVFEERTGSQLNFTDTNVPRSLGVSVSVTVEGTSSIYKLPIAPLITGSHPVDNKGTPSFSSVTNSNCVDLPASFFLKMNLPMPFSLSFIQRMGNATGIPVFETPPTLSPLYELIVQSQLQEEVGNPLTTPTHAMRFYASLPDQQHCYFLNGDAPVQDGHSLQGTLVSKIPFRHPAQVPALLDVIRHQAAANTLIGSCVKRTFIKDDTPGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEIMVKKNLPPAGSPGYGMGTGVDPTNPMGLPGVGGGNTPTGNSGGGNFAGPITSLFGINRSQSQGGECTPQGGAAGQQQQQQGGQSGDDFSKVTQNPILTSLLQITGAVGTSPTPQNSSSGSQPHQTPPPTSSPATNTKNHPMLMNLLKDNPAQDFAALYGSSPLERQNSSSGSPRTDGMGGTCPGSGTKGKKKRPRGMEKGGVPGAGGGGMGGMNKQQSGSMQPHHHQHQPTEDDFHRELFSMDVDASQNPIFDVNLPGDGLDTPHSITPAPSQCGTPPSGAGVSYHSQSHVQSQQQQQPPPGSSLPRMVRLSSSDSIGADINEILSDLPEQTGKGGSGSHGQHHLGSGEDGGPLGTPHRDSSSSGQGSAVFEADIFNTNSNENPFTNAADLIAEATATTPTSDSSSTNFFPDTVDFNPELLTSSHGFPQAYFDDSSPSADGDLDLVKGFGGSSQQNTPSGTPQNPTPHGQSTPDPSLKDPFDMSGMVFGGSSGGGKPLLGQALDLGDSHSSHMGGGQSPLMMAMGGGSSDFKSGEAKAKQQQQQGLMRTKDDNGGGSGRSSGMGMTGSSSTEGKQVKRSRTPSSEGKSKDKPPKRKKLDPDGKSPSHSTGGRPYTPPSGGSGSGGSIGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPKGTLSGGKTSSHGGYTSSSSAGGGTGGAGSTSGSKSHHSHSSSSSGKIKSKEGTLGQAISSKPGSVGGGVGGGPPQMKSSSQGMGVGKPGSSPITKHGLSGSGSSGGGVGSGNKMKPQGGKPPGSLMNPNIKPNISPSHSRPSGSDKLSSTMKMQQSQVPGTPPSSKAKSPMGSGGGGLVGSKSSSGGGMGSQKQLGGGGSSSGSSSSTSSSSSSSSGSMPFSGGSQSQYGSSGGGGGGCGGGQGNNANNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGGPEDEGEPPVGGSGGGGPGGGPPNLGPSSKHGMSSQGGEYPIKREKSEKEGKSKVSVSVGASGDKKLIDPKTGGVSSTGVAKIIISKPDGGSPSIKAKVTLQKPGEGSGESMRPQLSGLKASPLFSGSTPKHDRSSPSHSRSPGYTPLNHDSESESGSSSVAEKSHQNSPSSDDDQAMRPVPPQDYMSSMPLSSGEKHKKHKKEKKKQKERERERDKDREREKKKLSSMSTGNVSHGPMKADSWSRSPILASDTSLSMMGSDRPSRPSPVYMRNEDDDLMDSALTGNL
Length1793
PositionMiddle
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.04
Grand average of hydropathy-0.657
Instability index54.29
Isoelectric point8.92
Molecular weight184990.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12007
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1370.40|     169|     170|    1195|    1363|       1
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  629-  790 (176.91/32.43)	GGEC..T.........P..qgG.AAG..QQQQQ..QGGqSGDDFSKVT.QNP....................ILTSLLQITGAVGTSptpqNSSSGSQP..HQTPPPT.SSPATNTKNHPmLMN.LLKDNP...AQDFAALYGSSPlerQN..SSSgsprTD.GMG.............GTCPGSGTkgkkkrprgMEKGGVPG...........AG....GGGMG.GMNK..QQ.SG.S............MQP............H
  791-  951 (174.64/31.91)	HHQH..Q.........P....T.EDDfhRELFS..MDV.DASQNPIFDVNLPGDGLD........TPHS...ITPAPSQCGTPPSGA....GVSYHSQS..H....VQ.S.............Q.QQQQPP...P......GSSLP...RMvrLSS....SD.SIGadineilsdlpeqTGKGGSGS.........HGQHHL.G...........SGED..GGPLG.TPHR..DSSSS.GQGS.....AVF.EADifNTNSN.EN.PF
  952- 1074 (131.09/22.02)	TNAA..D.........L....I.AEA..TATTPtsDSS.STNFFPD.TVDFNPELL........TSSHGfpqAYFDDSS...............P....................SADGD.L.D.LVK...........GFGGSSQ...QN..TPS........................GTP.QNP..........TPHGQSTpdpslkdpfdmSGMV..FGG.S.SG........G.GKP........L.LGQ..AL..D.LG.DS
 1080- 1198 (156.32/27.75)	GGGQ..S.........PlmmaM.GGG..SSDFK..SGE.A.....KAKQQQQQGLM.......RTKDDN...GGGSGRSSGMGMTGS....SSTEGKQV..KRSRTPS.SEG..KSKD...........KP...PK.RKKLD...P...DG..KSP....SH.STG..............GRPYTPP............SGGSG..............S..GGSIG.GGSK.....................................
 1200- 1363 (295.02/59.24)	................P....G.SSG..RSQTP..PGG.ATPPIPKITIQIPKGTLSGG....KTSSHG...GYTSSSSAGGGTGGA....GSTSGSKS..HHSHSSS.SSGKIKSKEGT.LGQ.AISSKP...GSVGGGVGGGPP...QM..KSS....SQ.GMG.............VGKPGSSP.........ITKHGLSG...........SGSS..GGGVG.SGNK..MKPQG.GKPP.....GSL.MNP..NIKPN.IS.PS
 1369- 1479 (155.76/27.63)	GSDKlsS.........T....M.KMQ..QSQV...PG...TPPSSK..AKSPMGSGGGGlvgsKSSSGG...GMGSQKQLGGG........GSSSGSSS..STSSSSS.SSS......G.........SMP...FS......GGSQ...S................................................QYGSSG...........GG....GGGCG.GGQG..NNAN................NP..NAK........
 1480- 1594 (114.35/18.22)	.........................G..KS..P..SRN.KKPSL...TAVI.......D....KLKSVG...G.......GG.............GPE................D..EG..E........PpvgGSGGGGPGGGPP...NL..GPS....SKhGMS..............SQGGEYP.........IKREKSEK...........EGKSkvSVSVGaSGDKklIDPKT.GGVS.....STG.VAK..II....ISkPD
 1595- 1774 (166.32/30.02)	GGSP..SikakvtlqkP....GeGSG..ESMRP..QLS.GLKASPLFSGSTPKHDRSSP....SHSRSP...GYTPLNH......DS....ESESGSSSvaEKSHQNSpSSDDDQAMRPV.PPQdYMSSMP...LS.SGEKHKKHK...KE..KKK....QK.ERE.............RERDKDRE.........REKKKL.............SSMS..TGNVS.HG.P..MKADSwSRSPilasdTSLsMMG..SDRPSrPS.P.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12007 with Med1 domain of Kingdom Metazoa
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