<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12005

Description mediator of RNA polymerase II transcription subunit 24 isoform X1
SequenceMKVVNLKQAILQAWKERWSDYQWAINIKKNFPKGATWDYLNLAEALMEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLLAISKFDDFSRELCVKSLLEIMDMFCHRLSCHGKAEECIGLCRALLGVVVWLLTGCAWYCERLRELGPSASTEANLRACLERLRDLVNSQKNRALVHIARLEDQASWTNVEQALLKVTEGLNSLTNQTLRGKLEECISLVKSIPTILSEQSDPPHHSLFPSVHAFIMLEGTMNLTGETQPLVEQLMMIKRMQRIPAPVFVLEIWKACFTGLIESPEGTEELKWTAFTFLKIPQVLLRLKKYPQGEKVQQDFMDDVNIAFEYLLKLTPLLDKADQRCNCDCLSMLLQECNKLSLLSDSNTTNLTSKREYAPRLKTAENANIQPNPGLILRAEPTVTNILKTVDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSDPSPSGETPFFETWLQTCMPEEGKTLNPDHPCFRPESGKVESLVALLNNSSEMKLVQMKWHEICLSTPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLVAHVRMLGLDEREKPQTMIRQLMTPLYGENTLQFYNERVVIMSSILENMCADVFQQTGLALRPPMEGQEPIPYRNLLSAKEPIHEALRKQFRSVLWKGWVDSGALHLFESLLHTGGVFWFTNNLVKELLKETRQEWANRVVELLYSIFCLDTQQITLTLLGHILPNLLTDSAHWHSLADPPGKALAKLSVWCALSSFSTHHKGQASARQRKRQREDIEDYSSLFPLDDTQPSKLMRLLSSNEDEPVVLSSPGDRSMSTSLSASQLHTVNMRDPLNRVLANLFLLISSILGSKTAGPHTQFVQSFMEECVECLEQGSRGSILQFMPFTMVSELVKLPALAKPKVVLGITDLTLPLGRRVAAKAISAL
Length986
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.07
Grand average of hydropathy-0.043
Instability index45.19
Isoelectric point6.66
Molecular weight110400.13
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12005
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.95|      49|     194|     194|     274|       1
---------------------------------------------------------------------------
  222-  274 (75.19/91.05)	IPTILSEQSDPPHHSlFpsVHAFiMLEGTMNLTGETQPLVEQLM...MIKRMQRIP
  905-  956 (80.76/37.16)	ISSILGSKTAGPHTQ.F..VQSF.MEECVECLEQGSRGSILQFMpftMVSELVKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      23|     115|     661|     684|       2
---------------------------------------------------------------------------
  661-  684 (37.87/32.52)	IMSSILENMCADVFQQTGLAlRPP
  779-  801 (43.40/32.15)	LLGHILPNLLTDSAHWHSLA.DPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.78|      26|     114|     418|     443|       3
---------------------------------------------------------------------------
  418-  443 (45.60/33.78)	KTVDADHSK.SPE.GLLGVLGHMLSGKS
  534-  561 (38.18/26.86)	KTLNPDHPCfRPEsGKVESLVALLNNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.94|      13|      15|      79|      93|       6
---------------------------------------------------------------------------
   79-   93 (19.82/19.86)	LLAIskFDDFSREL.C
   97-  110 (23.12/15.15)	LLEI..MDMFCHRLsC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.03|      12|      97|     111|     122|       7
---------------------------------------------------------------------------
  111-  122 (24.94/16.50)	HGKAEECIGLCR
  209-  220 (22.09/13.78)	RGKLEECISLVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.57|      11|      31|     304|     314|      10
---------------------------------------------------------------------------
  304-  314 (19.61/11.42)	AFTF.LKIPQVL
  337-  348 (14.96/ 6.99)	AFEYlLKLTPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.07|      17|      17|     140|     156|      11
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  140-  156 (26.95/15.47)	ERLRELGPSASTEANLR
  160-  176 (26.40/15.01)	ERLRDLVNSQKNRALVH
  178-  193 (19.73/ 9.45)	ARLEDQASWTNVEQAL.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12005 with Med24 domain of Kingdom Metazoa
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