<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12002

Description mediator of RNA polymerase II transcription subunit 26 isoform X2
SequenceMTSATATPQEMRDRLMQAIDGQSNICNMVAVMEVISYLEKYPITKEALEETRLGKLINDVRKKTKDEDLAKRAKKLLRTWQKLIEPGQSEALSKGHMGPPGTANGGMHPCRMDVSPPAAIPPSGKMVPELKSRNDFNNRYSPKAEKSGNRKRKGEQRDRRHIPVKISKITAYERTHNSRLPTNGIGASPEAFTDTCDPHPHLKSDKDSAELLDIDRLNKIPVNAVKPHPSSPGVAKPPSTSTLLKTAVLQQHGKMDLAVSGGGPHQPKHPRSNSHSPRSTKQDAVVKLSTTKSTTLLSPARSPRVMDSSGLGPSPLHSPQLLTPCMQGSLTIGPLPAESALHWDGPADVDQRLQQSTRRPDFLHSKASSQSEVKAEGDGSVTSTERKRRKKYRSRDYTVNLGGQPTEETTMPCRLKDRRLTFDPVTGQIKPSTLKESYPERAATVAPVTPELPRTELLKQNHCAQNSPVTPSPFQQTNWEELSRNEIIQSYLNRQSNVLTSSGAQTSGAHFFMSEYLKHEEHHIKEGRRKHMLVPNIPDTDLPGVSREVTNEDLNRIHKEHWPGVNGCYDTKDNWYEWTECISLDSHGDEGKLNILPYVCLD
Length602
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.04
Grand average of hydropathy-0.849
Instability index58.58
Isoelectric point9.18
Molecular weight66956.86
Publications









Function






Annotated function


ECO:0000256	RuleBase:RU364060

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP12002
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.20|      20|      20|     431|     450|       1
---------------------------------------------------------------------------
  410-  427 (27.17/12.16)	..T..MPCRLKDRRLTFDPVTG
  431-  450 (35.85/18.06)	PST..LKESYPERAATVAPVTP
  453-  471 (28.18/12.85)	PRTelLKQNH...CAQNSPVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     279.65|      87|     113|     115|     206|       2
---------------------------------------------------------------------------
  115-  206 (138.88/77.79)	SPPAAIPPSGKMVpeLKSRNDFNNRYSPKAEKSGNRKRKGEQRDRRHIP..VKISKITAYERTHNSRLPTNgiGASPEAFTDT.CDPHPhLKSDK
  231-  320 (140.77/66.07)	SPGVAKPPSTSTL..LKTAVLQQHGKMDLAVSGGGPHQPKHPRSNSHSPrsTKQDAVVKLSTTKSTTLLSP..ARSPRVMDSSgLGPSP.LHSPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12002 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GRRKHMLVPNIPDTDLPGVSREVTNEDLNR
2) IEPGQSEALSKGHMGPPGTANGGMHPCRMDVSPPAAIPPSGKMVPELKSRNDFNNRYSPKAEKSGNRKRKGEQRDRRHIPVKISKITAYERTHNSRLPTNGIGASPEAFTDTCDPHPHLKSDKDSAELLDIDRLNKIPVNAVKPHPSSPGVAKPPSTSTLLKTAVLQQHGKMDLAVSGGGPHQPKHPRSNSHSPRSTKQDAVVKLSTTKSTTLLSPARSPRVMDSSGLGPSPLHSPQLLTPCMQGSLTIGPLPAESALHWDGPADVDQRLQQSTRRPDFLHSKASSQSEVKAEGDGSVTSTERKRRKKYRSRDYTVNLGGQPTEETTMPCRLKDRRLTF
3) PVTGQIKPSTLKESYPERAATVAPVTPELPRTELLKQNHCAQNSPVTPSPFQQTNWE
527
84
424
556
422
480










Molecular Recognition Features






MoRF SequenceStartStop




NANANA