<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11997

Description cyclin-dependent kinase 19 isoform X1
SequenceMDYDFKTKLAAEREKVEDLFEYEGCKVGRGTYGHVYKAKRKDGEDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFLEDPLPTSDVFAGCQIPYPKREFLNEDEPDEKTEKKIENPVQQHQQTTAQAQQQSGTQQASNQQSSTQTNGNAGGTGANAGGGLQHGQDQGPPNKKSRTGPSGASSGTGIHQHSSSRLGYQSNVQGSTQSQGYSSSSQQSSQYSHQSHRY
Length485
PositionKinase
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.09
Grand average of hydropathy-0.726
Instability index48.05
Isoelectric point8.52
Molecular weight55025.39
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11997
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.76|      35|      67|     110|     144|       1
---------------------------------------------------------------------------
  110-  144 (62.96/50.12)	FHRASKANKKPMQLPRGMVKSLLY...QILDGI.HYLHA
  176-  214 (52.80/40.74)	FARLFNSPLKPLADLDPVVVTFWYrapELLLGArHYTKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.29|      26|      72|     376|     401|       2
---------------------------------------------------------------------------
  376-  401 (45.09/24.98)	VQQHQ......QTTAQA....QQQSGTQQASNQQSS
  403-  427 (24.07/10.29)	...........QTNGNAggtgANAGGGLQHGQDQGP
  445-  476 (38.13/20.12)	IHQHSssrlgyQSNVQG....STQSQGYSSSSQQSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11997 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPDEKTEKKIENPVQQHQQTTAQAQQQSGTQQASNQQSSTQTNGNAGGTGANAGGGLQHGQDQGPPNKKSRTGPSGASSGTGIHQHSSSRLGYQSNVQGSTQSQGYSSSSQQSSQYSHQSHRY
351
485










Molecular Recognition Features






MoRF SequenceStartStop




1) IHQHSSSRLGYQSNVQGSTQSQGYSSSSQQSSQYSHQSHRY
2) PPNKKSRTGP
445
427
485
436