<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11991

Description mediator of RNA polymerase II transcription subunit 26-like isoform X3
SequenceMVAVLEVITYLEKFPITKEALEETRLGKLINDVRKKTKDKDLAKRAKKLLRSWQKLIDPGQNETPSRGAVSVSGSANGSAHPCRTDVPPPDVSLAGKGVQEVKTRNDVHNTYSPKAEKSSSRKRRGEQKDSVHLPAKTSKMSPNEQMHNSTPPPPTNGIAGNPEAPQDLEATPSPDRARTEHIENEKHSRIPVNAVKPHPSSPGIAKLPSTSSLLKTAVLQQQARLDEGGGQYLTKSPRCASSPRTMKQETMSKHSSTYAPKGTIPSPARSPRLPSSQPLTSPAQVSHVNGPPPPAHRASLHWPGSTEATTNPPHSTATLEPLPVFLPTTHPAPQNSESAELHRPTPSSSVMVVKAEAEVSASSSDRKKRKKYRSRDYSVNLQGQDTEDKTKPVRLKERRLTFDPVTGQIKSMVHKEPCQVEEPPMPPSPKPQQRTDLHPQQPPTPSPFQQTNWKELSRNEIIQSYLNLQSNVLTSSRVQAPGAHFFMSEYLKREESDLREARRGVHVLQLDSSVTDTPGVSREVTDKDLHRVHTEHWQGVNGCYDTKGTWYDWTECISLDPHGDESKLNILPYICLD
Length578
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.04
Grand average of hydropathy-0.913
Instability index65.25
Isoelectric point9.30
Molecular weight63958.09
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11991
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     240.26|      44|      44|     152|     195|       1
---------------------------------------------------------------------------
   88-  136 (50.29/18.93)	.PPPDVSLAGKGvqevKTRNDVHNTYSPkaEKSSSRKRRGEQKDSVHLPA
  152-  195 (77.50/33.26)	PPPPTNGIAGNP....EAPQDLEATPSP..DRARTEHIENEKHSRIPVNA
  198-  241 (61.67/24.92)	PHPSSPGIAKLP....STSSLLKTAVLQ..QQARLDEGGGQYLTKSPRCA
  292-  325 (50.80/19.20)	PPPPAHR..ASL....HWPGSTEATTNP..PHS.TATLEP.....LPV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.33|      26|      71|     260|     287|       2
---------------------------------------------------------------------------
  243-  263 (28.11/11.28)	........SPRTMKQETMSKHSSTYAPKG
  266-  291 (47.28/17.90)	PSP...ARSPRLPSSQPLTSPAQVSHVNG
  428-  450 (27.93/ 8.71)	PSPkpqQRTDLHPQQPPTPSPFQ......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      20|      22|     366|     385|       3
---------------------------------------------------------------------------
  366-  385 (33.85/27.26)	DRKKRKKYRSRDYSVN.LQGQ
  389-  409 (28.60/21.74)	DKTKPVRLKERRLTFDpVTGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.51|      27|     485|      25|      54|       4
---------------------------------------------------------------------------
   25-   54 (36.96/37.30)	RLGKLIND...VRKKTKDKDLaKRAKklLRSWQ
  510-  539 (41.56/29.68)	QLDSSVTDtpgVSREVTDKDL.HRVH..TEHWQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11991 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLLRSWQKLIDPGQNETPSRGAVSVSGSANGSAHPCRTDVPPPDVSLAGKGVQEVKTRNDVHNTYSPKAEKSSSRKRRGEQKDSVHLPAKTSKMSPNEQMHNSTPPPPTNGIAGNPEAPQDLEATPSPDRARTEHIENEKHSRIPVNAVKPHPSSPGIAKLPSTSSLLKTAVLQQQARLDEGGGQYLTKSPRCASSPRTMKQETMSKHSSTYAPKGTIPSPARSPRLPSSQPLTSPAQVSHVNGPPPPAHRASLHWPGSTEATTNPPHSTATLEPLPVFLPTTHPAPQNSESAELHRPTPSSSVMVVKAEAEVSASSSDRKKRKKYRSRDYSVNLQGQDTEDKTKPVRLKERRLTFDPVTGQIKSMVHKEPCQVEEPPMPPSPKPQQRTDLHPQQPPTPSPFQQTNWK
48
455










Molecular Recognition Features






MoRF SequenceStartStop




1) LAKRAKKLLRSWQKLID
42
58