<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11989

Description mediator of RNA polymerase II transcription subunit 26-like isoform X1
SequenceMTTASATPQQMRDRLLQAIDSHSNQIHNMVAVLEVITYLEKFPITKEALEETRLGKLINDVRKKTKDKDLAKRAKKLLRSWQKLIDPGQNETPSRGAVSVSGSANGSAHPCRTDVPPPDVSLAGKGVQEVKTRNDVHNTYSPKAEKSSSRKRRGEQKDSVHLPAKTSKMSPNEQMHNSTPPPPTNGIAGNPEAPQDLEATPSPDRARTEHIENEKHSRIPVNAVKPHPSSPGIAKLPSTSSLLKTAVLQQQARLDEGGGQYLTKSPRCASSPRTMKQETMSKHSSTYAPKGTIPSPARSPRLPSSQPLTSPAQVSHVNGPPPPAHRASLHWPGSTEATTNPPHSTATLEPLPVFLPTTHPAPQNSESAELHRPTPSSSVMVVKAEAEVSASSSDRKKRKKYRSRDYSVNLQGQDTEDKTKPVRLKERRLTFDPVTGQIKSMVHKEPCQVEEPPMPPSPKPQQRTDLHPQQPPTPSPFQQTNWKELSRNEIIQSYLNLQSNVLTSSRVQAPGAHFFMSEYLKREESDLREARRGVHVLQLDSSVTDTPGVSREVTDKDLHRVHTEHWQGVNGCYDTKGTWYDWTECISLDPHGDESKLNILPYICLD
Length606
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.04
Grand average of hydropathy-0.910
Instability index64.36
Isoelectric point9.30
Molecular weight67105.55
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11989
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     239.19|      44|      44|     180|     223|       1
---------------------------------------------------------------------------
  116-  164 (50.35/19.21)	.PPPDVSLAGKGvqevKTRNDVHNTYSPkaEKSSSRKRRGEQKDSVHLPA
  180-  223 (77.54/33.60)	PPPPTNGIAGNP....EAPQDLEATPSP..DRARTEHIENEKHSRIPVNA
  226-  269 (60.47/24.56)	PHPSSPGIAKLP....STSSLLKTAVLQ..QQARLDEGGGQYLTKSPRCA
  320-  353 (50.83/19.47)	PPPPAHR..ASL....HWPGSTEATTNP..PHS.TATLEP.....LPV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.33|      26|      71|     288|     315|       2
---------------------------------------------------------------------------
  271-  291 (28.11/11.77)	........SPRTMKQETMSKHSSTYAPKG
  294-  319 (47.28/18.71)	PSP...ARSPRLPSSQPLTSPAQVSHVNG
  456-  478 (27.93/ 9.06)	PSPkpqQRTDLHPQQPPTPSPFQ......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      20|      23|     394|     413|       4
---------------------------------------------------------------------------
  394-  413 (33.85/21.70)	DRKKRKKYRSRDYSVN.LQGQ
  417-  437 (28.60/17.29)	DKTKPVRLKERRLTFDpVTGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.51|      27|     485|      53|      82|       5
---------------------------------------------------------------------------
   53-   82 (36.96/33.47)	RLGKLIND...VRKKTKDKDLaKRAKklLRSWQ
  538-  567 (41.56/26.60)	QLDSSVTDtpgVSREVTDKDL.HRVH..TEHWQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11989 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLLRSWQKLIDPGQNETPSRGAVSVSGSANGSAHPCRTDVPPPDVSLAGKGVQEVKTRNDVHNTYSPKAEKSSSRKRRGEQKDSVHLPAKTSKMSPNEQMHNSTPPPPTNGIAGNPEAPQDLEATPSPDRARTEHIENEKHSRIPVNAVKPHPSSPGIAKLPSTSSLLKTAVLQQQARLDEGGGQYLTKSPRCASSPRTMKQETMSKHSSTYAPKGTIPSPARSPRLPSSQPLTSPAQVSHVNGPPPPAHRASLHWPGSTEATTNPPHSTATLEPLPVFLPTTHPAPQNSESAELHRPTPSSSVMVVKAEAEVSASSSDRKKRKKYRSRDYSVNLQGQDTEDKTKPVRLKERRLTFDPVTGQIKSMVHKEPCQVEEPPMPPSPKPQQRTDLHPQQPPTPSPFQQTNWK
76
483










Molecular Recognition Features






MoRF SequenceStartStop




1) RAKKLLRSWQKLI
73
85