<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11982

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMCRVRWLSNLRFPHSPVTKMCNPHSDRRKAAIRNTASSLPEIYTKKKCAMEVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSIGGPGQMQMQQIAQQQAQQQAQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQQQTAIQQQQFQVQQQMKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQLQQQHAQSIQHMVQQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQQQQQQLKIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPSTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPITGPTIVARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLKNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length813
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.822
Instability index76.98
Isoelectric point9.83
Molecular weight90078.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11982
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.68|      19|      19|     473|     491|       2
---------------------------------------------------------------------------
  272-  290 (32.02/ 6.04)	QNQQQQQAQNQQQQNQMHP
  379-  397 (34.33/ 7.24)	ALQQQQQQQQQQQVQQAQQ
  473-  491 (39.33/ 9.83)	SMPPPPQPQPSPQPPSSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     208.67|      40|      45|     185|     224|       3
---------------------------------------------------------------------------
  185-  210 (39.59/ 6.18)	................QM.QMQQI.AQQQAQQQ.AQQQSIQFQQF
  234-  271 (61.31/14.10)	.AMQQQTAI.QQQQF.QV.Q.QQM.KLQQLQQQhHQNQQLQ.QQH
  292-  331 (61.67/14.23)	RHQQQQIQL.QLQQQhAQ.SIQHM.VQQQQQQQ.VQSQP.QPTQL
  332-  375 (46.10/ 8.56)	PPHSQQQGMvPQSLAgQMaPTQHVpISSLSQQQ.QQQQQLKIQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.65|      27|      28|     500|     526|       4
---------------------------------------------------------------------------
  500-  526 (55.65/17.78)	PSPGGFQPS.PSPQPSHSPATAR..TPQNY
  529-  557 (41.41/11.33)	PSPGPLNTP.GNPSSVISPVGASqlEDQQY
  741-  768 (42.59/11.86)	PSVPPLQLSiPADYPDQSPQWAD..DGQVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.09|      27|      28|     588|     614|       6
---------------------------------------------------------------------------
  558-  582 (39.23/16.51)	MEKLKQLSKYI.EPLRRM.INKIDK.NE
  588-  614 (45.15/20.03)	LSKMKSLLNILTDPSTRCPLRTLQK.CE
  617-  644 (45.71/20.36)	LEKLKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.27|      13|     190|     454|     466|       7
---------------------------------------------------------------------------
  430-  444 (20.48/ 6.96)	PRLPRAASNPviPPN
  454-  466 (25.79/10.98)	PQQHQMMSSP..SPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.05|      12|      32|     136|     147|       9
---------------------------------------------------------------------------
  136-  147 (24.72/12.97)	LPGVPGVPGGIG
  170-  181 (23.32/11.81)	MAGVAGNPQSIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11982 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSIGGPGQMQMQQIAQQQAQQQA
2) KIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSK
3) LQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQL
4) QQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQ
5) QQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQ
117
371
257
315
202
200
566
302
364
236










Molecular Recognition Features






MoRF SequenceStartStop




NANANA