<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11981

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMCRVRWLSNLRFPHSPVTKMCNPHSDRRKAAIRNTASSLPEIYTKKKCAMEVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSIGGPGQMQMQQIAQQQAQQQAQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQQQTAIQQQQFQVQQQMKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQLQQQHAQSIQHMVQQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQQQQQQLKIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPSTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPITGPTIVARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLKNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length814
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.821
Instability index77.14
Isoelectric point9.83
Molecular weight90165.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11981
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     232.35|      46|      46|     280|     325|       4
---------------------------------------------------------------------------
  237-  301 (51.14/ 8.09)	..QQTA......I.QQQQFQVQQQmklqqlqqqhhqnqqlqqqhqnqqqqqaQNQQQQ........NQMHPSRH.......QQQQIQLQ
  302-  369 (68.14/13.61)	LQQQHAQSIQHMVQQQQQQQVQSQ.....................pqptqlpPHSQQQgmvpqslaGQMAPTQHvpisslsQQQQQQQQ
  370-  408 (55.83/ 9.61)	LKIQALQA..RALQQQQQQQQQQQ...........................vQQAQQA........AQ.............QAQQAAAQ
  409-  452 (57.24/10.07)	AQLAAAVPGQMMM.PRLGMQIPPR............................LPRAAS........NPVIPPNS.......AAVGGQ.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     247.61|      59|     153|     475|     534|       5
---------------------------------------------------------------------------
  475-  534 (112.63/46.86)	PPPPQPQPSPQP.PSSQ.......................................P..NSVSSSGPTPSPgGFQPSPSPQPSHS......PATARTPQNYGVPSPGP
  536-  630 (60.03/19.74)	NTPGNPSSVISPvGASQledqqymeklkqlskyieplrrminkidknedrkkdlskM..KSLLNILTDPST..RCPLRTLQKCE.......IALEKLKNDMAVPTP..
  631-  683 (74.96/26.57)	PPPPVP.CTKQQ.YLCQ.......................................PllDAVMAN..IRSP.VF........NHSlyrtfaPAMTAI...HGPPITGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.60|      13|      34|     190|     202|       6
---------------------------------------------------------------------------
  190-  202 (23.77/ 7.43)	QIAQQQAQQQAQQ
  224-  236 (24.83/ 8.11)	QTAMQQQQQTAMQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11981 with Med15 domain of Kingdom Metazoa
Unable to open file!