<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11980

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMCRVRWLSNLRFPHSPVTKMCNPHSDRRKAAIRNTASSLPEIYTKKKCAMEVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSRGPGQMQMQQIAQQQAQQQAQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQQQTAIQQQQFQVQQQMKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQLQQQHAQSIQHMVQQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQQQQQQLKIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPSTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPITGPTIVARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLKNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length815
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.830
Instability index76.94
Isoelectric point9.86
Molecular weight90378.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11980
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.26|      15|      20|     483|     502|       1
---------------------------------------------------------------------------
  463-  477 (28.81/ 7.61)	SPS.....PVQVQTPQSMP......P
  484-  509 (16.45/10.26)	SPQppssqPNSVSSSGPTPspggfqP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.64|      20|      20|     186|     205|       3
---------------------------------------------------------------------------
  186-  205 (40.49/10.19)	QMQQIAQQQAQQQAQQQSIQ
  228-  246 (31.40/ 6.07)	QQQQTAMQQ.QTAIQQQQFQ
  375-  392 (32.74/ 6.68)	QAR..ALQQQQQQQQQQQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.47|      20|      20|     292|     311|       4
---------------------------------------------------------------------------
  292-  311 (38.63/10.22)	HQQQQIQLQLQQQHAQSIQH
  314-  333 (36.83/ 9.34)	QQQQQQQVQSQPQPTQLPPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.49|      21|      26|     129|     154|       5
---------------------------------------------------------------------------
  129-  154 (36.43/23.77)	PMNALTN.......LPGVPGVPGGigmgpRPPG
  156-  183 (35.06/13.29)	PMGGMGQmqmgqhaMAGVAGNPQS.....RGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.09|      27|      28|     590|     616|       6
---------------------------------------------------------------------------
  560-  584 (39.23/19.47)	MEKLKQLSKYI.EPLRRM.INKIDK.NE
  590-  616 (45.15/23.55)	LSKMKSLLNILTDPSTRCPLRTLQK.CE
  619-  646 (45.71/23.94)	LEKLKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.34|      20|      85|     338|     358|      10
---------------------------------------------------------------------------
  338-  358 (32.56/18.91)	GM.VPQSLAgQMAPTQHVPISS
  424-  444 (28.78/11.14)	GMqIPPRLP.RAASNPVIPPNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.10|      17|     121|     404|     421|      12
---------------------------------------------------------------------------
  404-  420 (28.93/12.93)	AAAQAQLAAAVPGQMMM
  445-  461 (31.17/ 9.72)	AAVGGQQLPQVQQHQMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.49|      21|      28|     503|     528|      13
---------------------------------------------------------------------------
  503-  528 (36.17/18.95)	SPGgfqpsPSPQPSH.....SPATAR..TPQNY
  532-  559 (29.66/ 9.53)	SPG.....PLNTPGNpssviSPVGASqlEDQQY
  753-  770 (30.66/ 9.18)	........PADYPDQ.....SPQWAD..DGQVY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11980 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSK
2) LQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQL
3) QQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQ
4) RDIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSRGPGQMQMQQIAQQQAQQQAQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQ
370
256
314
116
568
301
363
235










Molecular Recognition Features






MoRF SequenceStartStop




NANANA