<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11979

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMCRVRWLSNLRFPHSPVTKMCNPHSDRRKAAIRNTASSLPEIYTKKKCAMEVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSIGGPGQMQMQQIAQQQAQQQAQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQQQTAIQQQQFQVQQQMKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQLQQQHAQSIQHMVQQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQQQQQQLKIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPSTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPITGPTIVARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLKNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length815
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.819
Instability index76.73
Isoelectric point9.83
Molecular weight90305.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11979
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.79|      17|      21|     362|     382|       2
---------------------------------------------------------------------------
  272-  289 (29.02/ 6.59)	QN...QQ.QQQAQNQQQQnQMH
  376-  396 (25.77/ 6.83)	QAralQQqQQQQQQQQVQ.QAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     262.78|      45|      45|     180|     224|       3
---------------------------------------------------------------------------
  180-  221 (78.07/20.72)	...IGGPGQMQMQQIAQQ................QAQQQAQQQSIQFQQFQAQQQQTAM..QQ
  222-  256 (63.87/15.41)	QQQ......TAMQQ..QQ................QTAMQ.QQTAIQQQQFQVQQQMK.L..QQ
  295-  335 (61.91/14.67)	QQQI....QLQLQQQHAQ................SIQHMVQQQ..QQQQVQSQPQPTQLppHS
  410-  470 (58.93/13.56)	QLAAAVPGQMMMPRLGMQipprlpraasnpvippNSAAVGGQQLPQVQQHQMMSSPSPV..QV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.25|      27|      28|     502|     528|       4
---------------------------------------------------------------------------
  502-  528 (54.24/19.07)	PSPGGFQPS.PSPQPSHSPATAR..TPQNY
  531-  559 (43.99/14.03)	PSPGPLNTP.GNPSSVISPVGASqlEDQQY
  743-  770 (47.01/15.52)	PSVPPLQLSiPADYPDQSPQWAD..DGQVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.09|      27|      28|     590|     616|       5
---------------------------------------------------------------------------
  560-  584 (39.23/20.00)	MEKLKQLSKYI.EPLRRM.INKIDK.NE
  590-  616 (45.15/24.24)	LSKMKSLLNILTDPSTRCPLRTLQK.CE
  619-  646 (45.71/24.63)	LEKLKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.89|      20|      32|     122|     143|       7
---------------------------------------------------------------------------
  124-  143 (41.08/26.91)	GGGPDP....MNALTN.......LPGVPGVP
  147-  177 (29.81/11.44)	GMGPRPpgapMGGMGQmqmgqhaMAGVAGNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.25|      12|     100|     257|     268|       8
---------------------------------------------------------------------------
  257-  268 (23.52/ 8.59)	LQQQHHQNQQLQ
  360-  371 (21.73/ 7.28)	LSQQQQQQQQLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11979 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSIGGPGQMQMQQIAQQQAQQQA
2) KIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSK
3) LQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQL
4) QQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQ
5) QQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQ
117
371
257
315
202
200
568
302
364
236










Molecular Recognition Features






MoRF SequenceStartStop




NANANA