<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11978

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMCRVRWLSNLRFPHSPVTKMCNPHSDRRKAAIRNTASSLPEIYTKKKCAMEVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSIGGPGQMQMQQIAQQQAQQQAQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQQQTAIQQQQFQVQQQMKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQLQQQHAQSIQHMVQQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQQQQQQLKIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPSTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPITGPTIVARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLKNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length816
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.819
Instability index76.88
Isoelectric point9.83
Molecular weight90392.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11978
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.91|      21|      21|     473|     493|       1
---------------------------------------------------------------------------
  198-  218 (33.37/ 6.13)	QQAQQQSIQFQQFQAQQQQTA
  315-  334 (36.93/ 7.88)	QQQQQQVQS..QPQPTQLPPH
  386-  406 (33.61/ 6.25)	QQQQQQVQQAQQAAQQAQQAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.04|      31|      33|     482|     514|       4
---------------------------------------------------------------------------
  482-  514 (52.02/15.74)	PQPSPQPPSSQPN.SVSSSGPTPSPGgfQPSP..SP
  516-  549 (40.02/ 7.45)	PSHSPATARTPQNyGVPSPGPLNTPG..NPSSviSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.46|      23|     137|     223|     245|       6
---------------------------------------------------------------------------
  223-  245 (44.69/14.57)	QQTAMQQQQQTAMQ..QQTAIQQQQ
  290-  311 (39.23/11.65)	PSRHQQQQIQLQLQ..QQHA.QSIQ
  364-  384 (30.54/ 7.01)	Q....QQQQQLKIQalQARALQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.69|      21|      85|     339|     359|       8
---------------------------------------------------------------------------
  339-  359 (40.00/18.54)	GM.VPQSLAGQMAP..TQHVPISS
  425-  445 (30.87/12.26)	GMqIPPRLP.RAAS..NPVIPPNS
  446-  464 (24.82/ 8.10)	AA.V....GGQQLPqvQQHQMMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.09|      27|      28|     591|     617|       9
---------------------------------------------------------------------------
  561-  585 (39.23/18.50)	MEKLKQLSKYI.EPLRRM.INKIDK.NE
  591-  617 (45.15/22.39)	LSKMKSLLNILTDPSTRCPLRTLQK.CE
  620-  647 (45.71/22.76)	LEKLKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      13|     501|     169|     183|      13
---------------------------------------------------------------------------
  169-  183 (21.45/15.51)	AMAGVAGNPqsIGGP
  673-  685 (27.35/13.68)	AMTAIHGPP..ITGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11978 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIHKKAQGGGPDPMNALTNLPGVPGVPGGIGMGPRPPGAPMGGMGQMQMGQHAMAGVAGNPQSIGGPGQMQMQQIAQQQAQQQA
2) KIQALQARALQQQQQQQQQQQVQQAQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAASNPVIPPNSAAVGGQQLPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYGVPSPGPLNTPGNPSSVISPVGASQLEDQQYMEKLKQLSK
3) LQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRHQQQQIQLQL
4) QQQQQQQVQSQPQPTQLPPHSQQQGMVPQSLAGQMAPTQHVPISSLSQQQ
5) QQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQTAMQ
117
371
257
315
202
200
569
302
364
236










Molecular Recognition Features






MoRF SequenceStartStop




NANANA