<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11971

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSWISDRSTRLTGGPGQMQMQQIAQQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQQTAMQQQTAIQQQQFQVQQQLKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRLQQQQQIVQLQLQQQHAQAQAQAQAQAQAQAQAQAQAQSIQHMVQQQQQVQAQSQPQAAQLPPHSQQQQGMVPQSLAGQMPSTQHVPISSLSQQQQQQQLKIQALQARAMQQQVQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAAPNPAIPPNSAAMGGQQIPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYSVPSPGPLNTPGNPSSVMSPSGANQQEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPIMGPIIAARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLQNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length653
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.849
Instability index80.73
Isoelectric point9.66
Molecular weight72493.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11971
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     174.99|      36|      36|      21|      56|       1
---------------------------------------------------------------------------
   17-   52 (70.67/14.06)	QM...QM.QQIA.QQQQSIQFQQFQAQQQQTAMQQQQQTAM
   53-   88 (57.82/ 9.87)	QQ...QQ.QQTAmQQQTAIQQQQFQVQQQLK.LQQLQQQHH
  115-  153 (46.50/ 6.17)	HPsrlQQqQQIV.QLQLQQQHAQAQAQAQAQA.QAQAQAQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.30|      20|      28|     174|     198|       3
---------------------------------------------------------------------------
  173-  194 (33.80/ 8.79)	QPQAaqLPPHSQ.....QQQGMVPQSL
  309-  333 (29.49/ 7.19)	TPQS..MPPPPQpqpspQPPSSQPNSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.47|      23|      28|     340|     366|       4
---------------------------------------------------------------------------
  219-  241 (32.69/ 6.36)	KIQALQARAMQQQVQ.QAAQQAQQ
  341-  364 (37.78/ 8.26)	SPGGFQPSPSPQPSHsPATARTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.90|      27|      28|     428|     454|       5
---------------------------------------------------------------------------
  404-  427 (24.91/ 8.92)	LSKyiepLRRMINKI.DKNED......RK.KD
  428-  454 (46.87/22.81)	LSK....MKSLLNILTDPNTRCPLRTLQK.CE
  457-  484 (45.12/21.70)	LEK....LKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.91|      17|     179|     196|     216|       8
---------------------------------------------------------------------------
  199-  216 (28.49/16.03)	PSTQHVPiSSLSQQQQQQ
  380-  396 (31.43/ 7.22)	PSSVMSP.SGANQQEDQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.30|      20|      23|     247|     266|       9
---------------------------------------------------------------------------
  247-  266 (38.35/17.95)	QLAAAVPGQMMMPR...L.GMQIP
  268-  291 (29.96/12.31)	RLPRAAPNPAIPPNsaaMgGQQIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11971 with Med15 domain of Kingdom Metazoa
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