<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11967

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMVFGAAFIQSLRLQACLKTMSAMEVPGPESDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGLDPMNALTNLTGVPGGIAMGPRPPGAPMGGMGTMGQMQMGQHAMAGVAGNPQAIGGPGQMQMQQIAQQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQQTAMQQQTAIQQQQFQVQQQLKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRLQQQQQIVQLQLQQQHAQAQAQAQAQAQAQAQAQAQAQSIQHMVQQQQQVQAQSQPQAAQLPPHSQQQQGMVPQSLAGQMPSTQHVPISSLSQQQQQQQLKIQALQARAMQQQVQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAAPNPAIPPNSAAMGGQQIPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYSVPSPGPLNTPGNPSSVMSPSGANQQEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPIMGPIIAARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLQNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length793
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.729
Instability index74.29
Isoelectric point9.66
Molecular weight87284.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP11967
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     212.38|      28|      28|     216|     243|       1
---------------------------------------------------------------------------
  188-  212 (38.84/ 7.18)	QQQTAM..QQQQQQTAMQQQTAiQ....QQQ
  216-  242 (48.52/11.09)	QQQLKL..QQLQQQHHQNQQLQ.QQHQNQQ.
  291-  318 (44.42/ 9.43)	QAQAQA..QSIQHMVQQQQQVQ.AQSQPQAA
  325-  354 (37.43/ 6.62)	QQQQGMvpQSLAGQMPSTQHVP.ISSLSQQQ
  356-  382 (43.17/ 8.93)	QQQLKI..QALQARAMQ.QQVQ.QAAQQAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.13|      25|      28|     441|     466|       2
---------------------------------------------------------------------------
  400-  424 (39.96/ 9.82)	PRLGMQI.......PPRLPRAAPNP.AIPPNSA
  428-  459 (34.78/10.28)	GQQIPQ.vqqhqmmSSPSPVQVQTPqSMPPPPQ
  509-  529 (34.40/ 7.49)	PSPGPLN.......TPGNPSSV.....MSPSGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.95|      19|      28|     115|     141|       3
---------------------------------------------------------------------------
  115-  140 (33.31/25.30)	GIAMGPRPPGAPmggmgtmGQMQMGQ
  145-  163 (37.64/11.57)	GVAGNPQAIGGP.......GQMQMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      11|      28|     460|     471|       4
---------------------------------------------------------------------------
  460-  471 (21.21/ 9.02)	PQPSPQPPSSqP
  487-  497 (24.62/ 6.99)	PSPSPQPSHS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.04|      19|     104|     164|     184|       5
---------------------------------------------------------------------------
  166-  184 (35.90/ 6.89)	QQQQSIQFQ......QFQAQQQQTA
  262-  286 (27.14/ 6.39)	QQQQIVQLQlqqqhaQAQAQAQAQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.90|      27|      28|     568|     594|       6
---------------------------------------------------------------------------
  544-  567 (24.91/ 9.50)	LSKyiepLRRMINKI.DKNED......RK.KD
  568-  594 (46.87/23.98)	LSK....MKSLLNILTDPNTRCPLRTLQK.CE
  597-  624 (45.12/22.83)	LEK....LKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11967 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDP
2) QAQSQPQAAQLPPHSQQQQGMVPQSLAGQMPSTQHVPISSLSQQQ
3) QGGGLDPMNALTNLTGVPGGIAMGPRPPGAPMGGMGTMGQMQMGQHAMAGVAGNPQAIGGPGQMQMQQIA
4) QHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPS
5) QQQLKIQALQARAMQQQVQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAAPNPAIPPNSAAMGGQQIPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYSVPSPGPLNTPGNPSSVMSPSGANQQEDQQYMEKLKQLSK
548
310
96
227
356
581
354
165
258
546










Molecular Recognition Features






MoRF SequenceStartStop




NANANA