<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11966

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMVFGAAFIQSLRLQACLKTMSAMEVPGPESDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGLDPMNALTNLTGVPGGIAMGPRPPGAPMGGMGTMGQMQMGQHAMAGVAGNPQAIGGPGQMQMQQIAQQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQQTAMQQQTAIQQQQFQVQQQLKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRLQQQQQIVQLQLQQQHAQAQAQAQAQAQAQAQAQAQAQSIQHMVQQQQQVQAQSQPQAAQLPPHSQQQQGMVPQSLAGQMPSTQHVPISSLSQQQQQQQLKIQALQARAMQQQVQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAAPNPAIPPNSAAMGGQQIPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYSVPSPGPLNTPGNPSSVMSPSGANQQEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPIMGPIIAARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLQNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length794
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.729
Instability index74.45
Isoelectric point9.66
Molecular weight87371.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11966
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.60|      21|      25|     166|     190|       1
---------------------------------------------------------------------------
  177-  199 (39.77/ 6.80)	QAQQQQTAMQQQQQtaMQQQ....QQQ
  310-  335 (27.83/ 6.08)	QAQSQPQAAQLPPH.sQQQQgmvpQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.12|      27|      28|     465|     491|       4
---------------------------------------------------------------------------
  430-  456 (32.81/ 8.39)	........QIPQV.......QQHQMMSS.PSPvqvqTPQSMPP
  457-  488 (51.11/17.19)	PPQpqpspQPPSS.......QPNSVSSSGPTP....SPGGFQP
  489-  520 (28.20/ 6.18)	SPS....pQPSHSpatartpQNYSVPSPGPLN....TPGN...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.34|      34|      94|     258|     297|       5
---------------------------------------------------------------------------
  135-  169 (52.80/ 9.66)	QMQMG.QHAMAGVAGNPQA...IGGPGQMQ.mQQI.AQQQQ
  268-  308 (42.54/15.36)	QLQLQqQHAQAQAQAQAQAqaqAQAQAQAQsiQHMvQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.83|      27|     139|     204|     230|       6
---------------------------------------------------------------------------
  204-  229 (40.91/12.00)	.QQTAIQQQQF..QVQQQLKLQQLQQQHH
  356-  378 (34.84/ 8.85)	QQQLKIQALQA..RAMQ....QQVQQAAQ
  379-  405 (30.08/ 6.39)	QAQQAAAQAQLaaAVPGQMMMPRLGMQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.90|      27|      28|     569|     595|       8
---------------------------------------------------------------------------
  545-  568 (24.91/10.37)	LSKyiepLRRMINKI.DKNED......RK.KD
  569-  595 (46.87/26.17)	LSK....MKSLLNILTDPNTRCPLRTLQK.CE
  598-  625 (45.12/24.91)	LEK....LKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.08|      15|     296|     112|     129|       9
---------------------------------------------------------------------------
   97-  111 (26.43/16.91)	GGGLDPMNALTNLTG
  115-  129 (29.65/10.67)	GIAMGPRPPGAPMGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11966 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDP
2) QAQSQPQAAQLPPHSQQQQGMVPQSLAGQMPSTQHVPISSLSQQQ
3) QGGGLDPMNALTNLTGVPGGIAMGPRPPGAPMGGMGTMGQMQMGQHAMAGVAGNPQAIGGPGQMQMQQIA
4) QHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPS
5) QQQLKIQALQARAMQQQVQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAAPNPAIPPNSAAMGGQQIPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYSVPSPGPLNTPGNPSSVMSPSGANQQEDQQYMEKLKQLSK
549
310
96
227
356
582
354
165
258
547










Molecular Recognition Features






MoRF SequenceStartStop




NANANA