<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11964

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMVFGAAFIQSLRLQACLKTMSAMEVPGPESDWRSPAFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDIHKKAQGGGLDPMNALTNLTGVPGGIAMGPRPPGAPMGGMGTMGQMQMGQHAMAGVAGNPQARGPGQMQMQQIAQQQQSIQFQQFQAQQQQTAMQQQQQTAMQQQQQQTAMQQQTAIQQQQFQVQQQLKLQQLQQQHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPSRLQQQQQIVQLQLQQQHAQAQAQAQAQAQAQAQAQAQAQSIQHMVQQQQQVQAQSQPQAAQLPPHSQQQQGMVPQSLAGQMPSTQHVPISSLSQQQQQQQLKIQALQARAMQQQVQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAAPNPAIPPNSAAMGGQQIPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYSVPSPGPLNTPGNPSSVMSPSGANQQEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLRTLQKCEIALEKLKNDMAVPTPPPPPVPCTKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPIMGPIIAARKRKHEEDDRQTIPNILQGEVARLNAKFLVNLDPSFCSNNGTVHLICKLDDKNLPSVPPLQLSIPADYPDQSPQWADDGQVYGANPFLQNVHRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length793
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.03
Grand average of hydropathy-0.741
Instability index74.27
Isoelectric point9.71
Molecular weight87357.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11964
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     288.76|      36|      36|     161|     196|       1
---------------------------------------------------------------------------
  167-  203 (66.61/15.73)	QQSIQFQ.QFQAQQQQTAMQ....QQQQTAMQQ...QQ...QQ.TAmQ...Q
  204-  232 (41.85/ 6.56)	QTAIQQQ.QFQVQQQLK.LQ....QLQQQHHQN...QQ..............
  234-  271 (40.68/ 6.13)	....Q.Q.QHQNQQQQQAQN....QQQQNQMHPsrlQQ...QQqIV.QlqlQ
  272-  304 (43.14/ 7.04)	QQHAQAQaQAQAQA.....Q....AQAQAQAQA...QS..iQH.MV.Q...Q
  305-  342 (43.83/ 7.29)	Q.....Q.QVQAQSQPQAAQlpphSQQQQGMVP...QSlagQM.PS.T...Q
  343-  378 (52.66/10.56)	HVPISSL.SQQQQQQQLKIQ....ALQARAMQQ...QV...QQ.AA.Q...Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.75|      26|      27|     458|     483|       2
---------------------------------------------------------------------------
  430-  455 (41.88/11.82)	IPQVQQHQMMS.......SPSPVQVQTPQSMPP
  458-  483 (51.95/16.57)	QPQPSPQPPSS.......QPNSVSSSGPTPSPG
  486-  518 (43.92/12.78)	QPSPSPQPSHSpatartpQNYSVPSPGPLNTPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.53|      27|      29|      98|     124|       3
---------------------------------------------------------------------------
   98-  124 (50.04/20.18)	GGLDPMNALTNLTGVPGGIAMGP..R.PPG
  128-  156 (47.46/18.78)	GGMGTMGQMQMGQHAMAGVAGNPqaR.GPG
  395-  421 (44.03/16.92)	QMMMPRLGMQIPPRLPRA.APNP..AiPPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.90|      27|      28|     568|     594|       4
---------------------------------------------------------------------------
  544-  567 (24.91/ 8.79)	LSKyiepLRRMINKI.DKNED......RK.KD
  568-  594 (46.87/22.31)	LSK....MKSLLNILTDPNTRCPLRTLQK.CE
  597-  624 (45.12/21.23)	LEK....LKNDMAVPTPPPPPVPCTKQQYlCQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11964 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDP
2) QAQSQPQAAQLPPHSQQQQGMVPQSLAGQMPSTQHVPISSLSQQQ
3) QGGGLDPMNALTNLTGVPGGIAMGPRPPGAPMGGMGTMGQMQMGQHAMAGVAGNPQARGPGQMQMQQIAQ
4) QHHQNQQLQQQHQNQQQQQAQNQQQQNQMHPS
5) QQQLKIQALQARAMQQQVQQAAQQAQQAAAQAQLAAAVPGQMMMPRLGMQIPPRLPRAAPNPAIPPNSAAMGGQQIPQVQQHQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSSGPTPSPGGFQPSPSPQPSHSPATARTPQNYSVPSPGPLNTPGNPSSVMSPSGANQQEDQQYMEKLKQLSK
548
309
96
226
355
581
353
165
257
546










Molecular Recognition Features






MoRF SequenceStartStop




NANANA