<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11956

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELIYSVSGSSTRKPIYGHMPRSICTFSCRNAVAFTCTQALDEAAELGKDKDDLLMQEKQDRPMSFEHQYHVYVYDVEKPWEVFEVTRLDEAVQQLHWDSSGSRLLVIDRLGNTAIWKMKDYLMNSWELCHQSSVEGEEFLCAAWLHTGIMVRYDLDKRESYLYDGKFTRISFSPSLCQFGGKATDGWIGVTATGLVCVGVPGSEQGMTVVRNGLSQVRSRYQLAALAFSSNGNIIVACSDGNIASCIQCFTVTVTIDSNSTCSIQSNPHASFFVHAHTDPQYKDSPFARISHLDFTSREDSDTILVWSETDQLSCMESWHLQEQAVGLHKFFQGNLNTDTRQPFKLLKWVLRSNLSHSSPVSSVAMPRYPSALTKPESNPLLPKCILIAFRDGTVKMVNSYTFGIIASFNLETVRHSSYTVTGFPEKRRRASLHAVCIEQSYTGSVALLMDSQDQMYMLKLLNTRDPAMQAPLSHITSLFEYVLLTGRDWWDVLAVVKPGSIDTVIQRLSDDYMKQPNHMQELLKTRFLALKAALYKHSSGGQGKAGDCHTKLLLFSISTAFKSILRPKALGSQDKSPAERLAASCSKVMEPDLDKVMMSLNVENKDYVVEPATLQSLQPLIQWVADFSLSLLASLALYQTYPGHPGATIIHDPVAINTLRELLVIFRVWGLISSSCLPHFIATASNLDCLALLFKLLTKLWGICKDGGNAEYDEALVDECCSLPSQLMVPCVEQHVIMSSPMALQLALQHPQRFIINHPPEGAHKPNLVSSWTEGQYHTNALRDVVRQIFIGSSPAEDVRRCLRCGSLSLLRSTSKTAAMKAWDQRWSKMCLCGGHWKLDYADDSS
Length848
PositionTail
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.09
Grand average of hydropathy-0.126
Instability index49.77
Isoelectric point6.47
Molecular weight94835.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     231.18|      73|     439|     172|     251|       1
---------------------------------------------------------------------------
  172-  251 (107.56/91.31)	SFSPsLCQFggkATDGWIGVTATGLVCVGVPGsEQGMTVVRNGLSqVRSRYQLAALaFSSNGNIIVACSDGNI..ASCIQCF
  618-  692 (123.62/77.94)	SLQP.LIQW...VADFSLSLLASLALYQTYPG.HPGATIIHDPVA.INTLRELLVI.FRVWGLISSSCLPHFIatASNLDCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.77|      17|      59|     458|     474|       2
---------------------------------------------------------------------------
  458-  474 (31.73/22.77)	YMLKLLNTRDPAMQAPL
  520-  536 (29.04/20.21)	HMQELLKTRFLALKAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.47|      53|      58|     314|     371|       3
---------------------------------------------------------------------------
  314-  371 (84.80/70.18)	LSCMESWHLQEQAVgLHKFFQGNLNTDTRQPFKLLKWVLRSNLSHsspvSSVAMPRYP
  374-  426 (90.67/59.95)	LTKPESNPLLPKCI.LIAFRDGTVKMVNSYTFGIIASFNLETVRH....SSYTVTGFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.21|      59|     707|      67|     130|       4
---------------------------------------------------------------------------
   67-  130 (90.91/85.01)	EHQYHV.YVYDVEKpwEVFEVTRLDEAVQQLHwdSSGSrLLVIDRLGNTAIWKMKDYLMNSWELC
  776-  835 (102.30/71.95)	EGQYHTnALRDVVR..QIFIGSSPAEDVRRCL..RCGS.LSLLRSTSKTAAMKAWDQRWSKMCLC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11956 with Med16 domain of Kingdom Metazoa
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