<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11949

Description mediator of RNA polymerase II transcription subunit 14
SequenceMPPIEGQPPGPGGAGALAQPGPGTIPLATLIDFILQRTYHELSVLSELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANSASKVDKCAAISSFLDKQAMLFVDTADMLAKVAHETRMSARLPAFSIPCAIDVLTTGTYPRLPTCVKERIVPADPISPIEKRETLQRLNQIIEYRLVTSDLPPQMKKLKIANGRVKFLVEHEFEITLTLMGDGPSIPWRLLDIDILVEDHETGDGKALVHTLQVNYIHQLVQSRLLDNDRPLHDLYNCLHSFSQSLQLEVLHSQAERLRSQRLGDHIRVEEYTAGRSLVVSYWRLQVKRDTKPADQPPVYKLSIHVDEADPGKPLQVTHTPEIQGKESYRVAQAIKSDHLSIEKLLIQTIQVRSQARLRELEKDVKKFAGGPCEIKGVPPTLLVPVLFPCMDSEKMLISVDIQRGLFLTSMPQYGAKCKVADDIEESLNSGGRELARLMTELRIWLGIQRCEKSIQHLPAAAYSFIPLTQYAGHPIENLGPWKLYIKLLKQANFYVVVDIQAKGIKAIEYNYYLLQVEPCTFEKAENEIMDDIPTAYLRPKVITKFDTYAITHGPLAKIHDAEVDENEEESLERKRKILQGDVDGPPRKQARVAAYFVSELVHILAATEDRIPFVNLGQELQNRGIGHQGVQVDGNGSCYALTVVDIPCSADTEALKQDLLSCTFRVQGKTRSWHTELVFTNCPVMSTSPKEKSIIHRVVCMYELSHDGDASKLVQDFMDDWATLGHLYKAVLDFSIQYKNPSTHLHNMVEIKSYSYKRLVLGYGPSKLCSVNIQWSRDRTQFVLAFGTCGPSNTANPHTLVATQLQAEFNKHKSIATLAQTLHETWMPMAAICKLHTTPFMAQAPKAQAASVPQPNPLFSVIPQSSTHIRIGYRNTYPWWCMRESAKCKVADDIEESLNSGGRELARLMTELRIWLGIQRCEKSIQHLPAAAYSFIPLTQYAGHPIENLGPWKLYIKLLKQANFYVVVDIQAKGIKAIEYNYYLLQVEPCTFEKAENEIMDDIPTAYLRPKVITKFDTYAITHGPLAKIHDAEVDENEEESLERKRKILQGDVDGPPRKQARVAAYFVSELVHILAATEDRIPFVNLGQELQNRGIGHQGVQVDGNGSCYALTVVDIPCSADTEALKQDLLSCTFRVQGKTRSWHTELVFTNCPVMSTSPKEKSIIHRVVCMYELSHDGDASKLVQDFMDDWATLGHLYKAVLDFSIQYKNPSTHLHNMVEIKNYSYKRLVLGYGPSKLCSVNIQWSRDRTQFVLAFGTCGPSNTANPHTLVATQLQAEFNKHKSIATLAQTLHETWMPMAAICKLHTTPFMAQAPKAQAASVPQPNPLFSVIPQSSTHIRIGYRNTYCLDIHLRSNKMVSVRDGAYSWFDTSKVVEGFTPTPGLKTFLNHFVEEGVPSGMSRRRSTTEDDNPPSPVGMDSMETFMNQPQQIGSPVKKQDGGSGGGLRFPGPMTPPSNPHTPASPSGARLGQSGYSASPAAAFPLASPPSLQMGTPSPGNVLGVSSPGNPQLHVPSPGSFVPAPSPSSLGIHMPSPATAFISPQDCGLSYCLDIHLRSNKMVSVRDGAYSWFDTSKVVEGFTPTPGLKTFLNHFVEEGVPSGMSRRRSTTEDDNPPSPVGMDSMETFMNQPQQIGSPVKKQDGGSGGGLRFPGPMTPPSNPHTPASPSGARLGQSGYSASPAAAFPLASPPSLQMGTPSPGNVLGVSSPGNPQLHVPSPGSFVPAPSPSSLGIHMPSPATAFISPQGMLEGGSPYHGGGLVTPSPGPRNWPGSPSPASRHGTAHSPGAGHQALHSPPNRDLVMSPPSRMLPQRSWAASIPTLLTHEALNKLLTPTSTPGQGPGLGFLPCCPLQRFLGCVFLKRSLQRIVQTDDALQHIPPTEPGVVMFKSDSMQFRVALNPNTQQVLQMKITPSIDQWSHDELQVLERFFEVRVTCPPYKLYAVTAFTKLLAAPPRILKDCVQLMRLELMPDRSFKWGVHWCLTSAASSSPIVAGAPAVLIKGNKMLFMIQLTRMSAPPTPGGSDQQSIVIPILYDINTNITSMVDQSRNQPQGSSPQAMAVMNMLKRFTEYHANSAECSIFPAVRELMANLILPV
Length2130
PositionTail
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.07
Grand average of hydropathy-0.251
Instability index54.62
Isoelectric point8.11
Molecular weight234921.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11949
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    2096.19|     439|     470|     445|     911|       1
---------------------------------------------------------------------------
  445-  873 (925.65/450.22)	.........................PQY....GAKCKVADDIEESLNSGGRELARLMTELRIWLGIQRCEKSIQHLPAAAYSFIPLTQYAGHPIENLGPWKLYIKLLKQANFYVVVDIQAKGIKAIEYNYYLLQVEPCTFEKAENEIMDDIPTAYLRPKVITKFDTYAITHGPLAKIHDAEVDENEEESLERKRKILQGDVDGPPRKQARVAAYFVSELVHILAATEDRIPFVNLGQELQNRGIGHQGVQVDGNGSCYALTVVDIPCSADTEALKQDLLSCTFRVQGKTRSWHTELVFTNCPVMSTSPKEKSIIHRVVCMYELSHDGDASKLVQDFMDDWATLGHLYKAVLDFSIQYKNPSTHLHNMVEIKSYSYKRLVLGYGPSKLCSVNIQWSRDRTQFVLAFGTCGPSNTANPHTL...VATQLQAEFNKHKSIATLAQTLHETWM...PMAAICK..LHT.TP
  887- 1344 (940.36/497.00)	PQPNPlfsVIPQSsthirigyrntyPWWcmreSAKCKVADDIEESLNSGGRELARLMTELRIWLGIQRCEKSIQHLPAAAYSFIPLTQYAGHPIENLGPWKLYIKLLKQANFYVVVDIQAKGIKAIEYNYYLLQVEPCTFEKAENEIMDDIPTAYLRPKVITKFDTYAITHGPLAKIHDAEVDENEEESLERKRKILQGDVDGPPRKQARVAAYFVSELVHILAATEDRIPFVNLGQELQNRGIGHQGVQVDGNGSCYALTVVDIPCSADTEALKQDLLSCTFRVQGKTRSWHTELVFTNCPVMSTSPKEKSIIHRVVCMYELSHDGDASKLVQDFMDDWATLGHLYKAVLDFSIQYKNPSTHLHNMVEIKNYSYKRLVLGYGPSKLCSVNIQWSRDRTQFVLAFGTCGPSNTANPHTL...VATQLQAEFNKHKSIATLAQTLHETWM...PMAAICK..LHT.TP
 1484- 1530 (93.14/36.49)	..PGP...MTPPS.................................................................................................................................................................................................................................................................................................................................................................................................................NPHT....PASPSGARLGQSGYSASPAAAF........PLASPPS..LQMgTP
 1686- 1732 (93.14/36.49)	..PGP...MTPPS.................................................................................................................................................................................................................................................................................................................................................................................................................NPHT....PASPSGARLGQSGYSASPAAAF........PLASPPS..LQMgTP
 1797- 1837 (43.91/ 9.84)	PSPGP..............................................................................................................................................................................................................................................................................................................................................................................................................................rnwPGSPSPA..SRHGTAHSPGA.......ghqALHSPPNrdLVM...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     698.39|     153|     200|    1382|    1581|       2
---------------------------------------------------------------------------
 1345- 1483 (251.04/140.20)	.......................FM.AQAPKAQAASVPQPNPLFsVIPQSSthiriGyrntYCLDIHLRSNKMVSVRDGAYSWFDTSKVVEGFTPTPGLKTFLNHFVEEGVPSGMSRRRSTTEDDNPPSPVGMDSMETFMNQPQQIGSPVKKQ...DGGS...GGGLRF
 1531- 1685 (337.25/191.29)	SPGNVLGVSSPGNPQLHVPSPGSFVPAPSPSSLGIHMPSPATAF.ISPQDC.....G..lsYCLDIHLRSNKMVSVRDGAYSWFDTSKVVEGFTPTPGLKTFLNHFVEEGVPSGMSRRRSTTEDDNPPSPVGMDSMETFMNQPQQIGSPVKKQ...DGGS...GGGLRF
 1733- 1794 (110.09/56.66)	SPGNVLGVSSPGNPQLHVPSPGSFVPAPSPSSLGIHMPSPATAF.ISPQ........................................................................................................gmlEGGSpyhGGGL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.53|       9|     470|     901|     910|       3
---------------------------------------------------------------------------
  901-  910 (15.76/15.82)	THIRIgYRNT
 1372- 1381 (15.76/ 8.82)	THIRIgYRNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.00|      33|      93|     276|     308|       4
---------------------------------------------------------------------------
  276-  308 (55.63/43.11)	SQSLQLEVLHSQAERLRSQ.RLGDHIR.VEEYTAG
  370-  404 (45.37/33.61)	SDHLSIEKLLIQTIQVRSQaRLRELEKdVKKFAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     338.34|     107|    1721|     120|     229|       5
---------------------------------------------------------------------------
  120-  229 (179.55/101.06)	RM.SARLPAFSIPcaiDVLTTGTYPRL..PTCVKER.....IVPADPISPIEKRETLQR.LNQIIEYRLVTSDLPPQMKKLKI.ANGRVKFLVEHEFEITLTL.MGDGPSI.PWRLLDIDIL
 1842- 1960 (158.79/82.77)	RMlPQRSWAASIP...TLLTHEALNKLltPTSTPGQgpglgFLPCCPLQRFLGCVFLKRsLQRIVQTDDALQHIPPTEPGVVMfKSDSMQFRVALNPNTQQVLqMKITPSIdQWSHDELQVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.60|      15|      15|    1983|    1997|       6
---------------------------------------------------------------------------
 1983- 1997 (25.54/14.20)	KLLAAPPRILKDCVQ
 2000- 2014 (27.07/15.56)	RLELMPDRSFKWGVH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11949 with Med14 domain of Kingdom Metazoa
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