<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11947

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFPSQDNRSLKKPRLGPPDVYPQEHRQKEDELTHVSVKQGFNNIPHFNDEYGSAKHVTVMQMQNAIGSSLSAIIAKKTDLNTLQDTGKKKPIINTKDNFWPVTARSKQAIENWFKDLAGSKPLTQIGRKVPVFNKREEIFTTLCEYNVPLIRAAWFLKMNNAYTVAMNESKTKSKKQNIDPSSGKKQNIDPSSGKKQNIDPSSGKKQNIDPSSDWTITIYRFLKEHLSKIIEHYHGGSSGPQTSFLTATQTSHVDIDLALKQWQYTTRLARHMYEEGLLDRHEFLIWLVDTVDKLKSPDDNVLKLLLMQVLQYVDEITCAQSISRKLAHFCCKKLALMCNETGYSTPRSQSPLVTANANGQLTTTSAPQPNPVLGAFGEYTSCSQHRGLLLGLSAVLQTIVLKCPSAVVWNNLGEGKSASVLCGSPLDLLPCAPSSLPMPPGPNNAELRALIRSAEHQIKLRGQAAEVRWSSDKCQQSTIGFTISRILGALESLDRQNFERVEQTASLDTLYNKIFAAGQSKDQEPVSTDEATVNLLCEWAVSVKRSGCHRAIVVAKLLERRQNELTSELQESEILDEKDSLGSEAMAPSGLPIFQNLLIQYLDHRAPVLDESPSAENRTAFSNLISLFCELIRHDVFSHDAYMCTLISRGDLEASPPMHTAPGDSLGELASVKSENPSVKPEAAQEEQKMDVDTDTFDPDYDIFAFRDDPKSPDMNVDHSTQMLWELQEHLGKISPVGGAIGIRIGLVLSANFELVTSCCLGYLECLGIESIKVISLHSSWLRQQDVICTFSFKLTTMHG
Length803
PositionKinase
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.07
Grand average of hydropathy-0.363
Instability index48.59
Isoelectric point6.15
Molecular weight89200.39
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11947
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.78|      19|      19|     177|     195|       1
---------------------------------------------------------------------------
  177-  195 (40.89/25.35)	KKQNIDPSSGKKQNIDPSS
  197-  215 (40.89/25.35)	KKQNIDPSSGKKQNIDPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.09|      37|     219|     438|     475|       2
---------------------------------------------------------------------------
  438-  475 (61.44/45.92)	SLPM..PPGPNNAELrALIRSAEHQIKLRGQAAEVRWSSD
  658-  696 (59.66/39.55)	SPPMhtAPGDSLGEL.ASVKSENPSVKPEAAQEEQKMDVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.66|      15|      18|      88|     105|       3
---------------------------------------------------------------------------
   88-  102 (27.79/23.27)	TGKKKPIINTKDNFW
  128-  142 (25.87/11.54)	IGRKVPVFNKREEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.59|      18|     504|     217|     242|       4
---------------------------------------------------------------------------
  217-  242 (25.83/36.79)	WTitiyrfLKEHLSKIieHYHGGSSG
  728-  745 (35.76/23.04)	WE......LQEHLGKI..SPVGGAIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.54|      11|      19|      36|      46|       7
---------------------------------------------------------------------------
   36-   46 (20.65/15.15)	HVSVKQGFNNI
   58-   68 (20.89/15.41)	HVTVMQMQNAI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11947 with Med12 domain of Kingdom Metazoa
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