<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11946

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAEAAQEEQKMDVDTDTFDPDYDIFAFRDDPKSPDMNVDHSTQMLWELQEHLGKISPVGGAIASVKSDKEFQHTPAPPSVQQSEPQPPRKLSRHMQYATHFPIPQDDSCYHECNQRMIVLYGVGKARDEARHVCKKVSKEIMKLFSKKNSIDISSGDIGKTKKKKEKGEKDVGDPNYEGTFTRFQKLSYYDQHAVTSSCATQVLEQFSSFSSGNSTYLPLVENISFLFDLMEHCHNINSLIEFCIQPLKEFNNQEVQNMLKSGSPVLGSYITSMCLCIVAVLRKYHACLLVMPDLTSLAFEGLCGVVKHVNNPSDCSSAERCILAYLYDLYTSCSYLKAKYSEFFSGACSKVKQTLYAAIVPSASNFRWDPQFMTDVIENAKSRPDIQAIKQLNESSQNRYSFVCNAQINICNAQGAERLNEVSILCAELTACCNSLSSEWLGILRALCCSSNHCCGYIDVLALLDVSDLSLHDLLAVFTSVLIARHCFSMEDFVKHVALPSLLAACPSAGGDQDAEPGARLTCHLLLRLFKSDSDNNTPFPSSKSSSYIKASCDRHLLSAAHNGITVGPMLAVLKAMLVLGN
Length583
PositionKinase
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.08
Grand average of hydropathy-0.183
Instability index45.58
Isoelectric point5.89
Molecular weight64642.06
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11946
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.94|      38|     270|     259|     298|       1
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  259-  298 (63.60/50.97)	MLKSGS....PVL....GSYITSMclCIVAVLRKYHACLLVMPDLTSL
  530-  575 (57.35/38.36)	LFKSDSdnntPFPssksSSYIKAS..CDRHLLSAAHNGITVGPMLAVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.85|      39|     132|     170|     213|       3
---------------------------------------------------------------------------
  170-  213 (58.75/50.60)	KDVGDPNYEGTFTRFqKLSY.YDQHavtSSCaTQVLEQFSSFSSG
  308-  347 (69.10/42.28)	KHVNNPSDCSSAERC.ILAYlYDLY...TSC.SYLKAKYSEFFSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.30|      39|     138|     217|     258|       6
---------------------------------------------------------------------------
  217-  258 (60.13/47.03)	YLPLVENIS.FLFD...LMEHCHNINSLIEfcIQPLKEFnNQEVQN
  357-  399 (57.18/33.35)	YAAIVPSASnFRWDpqfMTDVIENAKSRPD..IQAIKQL.NESSQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11946 with Med12 domain of Kingdom Metazoa
Unable to open file!