<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11942

Description mediator of RNA polymerase II transcription subunit 23
SequenceMPDLVDMSDEIVNEVIQDVLQAEAIQEAFCGFLENSTKNEEMKNQSCQHTFKFFWASRDPSTYDGILKAYVSAVYNQRNSKRSQKLFSMLEYLVENSIVSAKQVCEAVLHCDKLKHENEALWCQTFQLLRKIVGGVDYKGCRDLFRLVLEKCQTIPMSANVSAVRQLDAALNVISYILDRNACLLPSYFAVNEIVKLTSEDRGGGPWPHWKLGQILSDFVETFRPTAQMVTLPGRRHLLPVVGHSSTTASAWRLTPTLKFPLHGPLPYDKEAQELQTDLLRYVLEQPYSRDMVCNMLSLNKQVKLRCLVLEEQLVELIVLAMERSESEDTSTEGSVVSQLLWQHLSSQLIFFVLFQFASFPHMVSSLYNKLKGSKLQKGRNHLMWVLLQFISGSIQKNPLQDFLPVLKLYDLLYTEKEPLSVPDIEKPYSTLSMAVTCIWIHLIRKAQTDNVKLKRPVPYTLKNHMDFLKQCLTVKNQPMPNYRIALLCNAYSTNTEYFSAPMSQLLEMIYGNGQSTTQLPGNITASAPSEPLPMDKLDSLTVHAKMSLIHSIVTRVIKHAHTKNTVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVVKSRAWGILHTLLEMFIYRLHHIQPHYRVQLLSHLHTLVALTNQNQLHLCVESTALRLINGLGSTEVQPQLSRFLQEPKSLALLSNESEELNRALVLTLARAMHVTGSDSLSNNWCKDIMTTIMQHTPHGWSSHTIACFPPALAEFFQQNPVPREEKTTLKRMVETEYRKWKSMNNESDLIAHFSMQGTPPLFICIIWRCLLEDGRVSTTAYKVLERLGSKTLSQHLRTFADYLVFEFATSGGGQQVQKCVNALNDMVWKCNIVTIDRLVLSLALRNLEGNEAQVCCLIIQLILLKPPDFTNRVKDFESENSPAHWKQKNWHEKHMAFHRKYPEKFYYEGLQDLSSPSQHQYLPVYFGNVCLRFLPVLDIVIHRFLELPSAQVSKSLENMLDHMGKLYKFHDRPVTYLYNTLHYYEKRLRDRPALKRRLVQSIIGAFKDIYPATWCVSEDYVSYMQRPADDIDWVPSEEYYIKLLARIVDTIAGKTPSPFLNCDWRFNEFPNPAAHALHATCIELMALPVASATVGSALMDTVLKNAAQVPREQIMSWMNAVGLILTALPDSYWMVINEKILFAVQTPILANFKPFEIFNFSTSHAVFGEVQCSYVLALCHALWHHASIGQISILPQFIKEQLKPVVHTEEQFLFICHLVGPFLQRFYAERTRCLLEFVVDLYEILEKVDKACEHLFHMDSISDFLYHIKYMFVGDGVKAEVDKIIFNLRPALKLRLRFISQRGKEETPQPSQ
Length1345
PositionTail
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.10
Grand average of hydropathy-0.088
Instability index43.71
Isoelectric point7.56
Molecular weight154211.14
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11942
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     688.31|     227|     294|     151|     443|       1
---------------------------------------------------------------------------
   57-  148 (46.45/11.71)	........................................................................................................................................................................................SRDPSTyDG....ilkAYVSAVYNQRNSkrSQKLFSML.EYLVE.NSIVSAkqvCEAVLHCDKL.KHENEALWCqtfqL....LRKIV..GGVDYKG.CRD......LFRL..............................V
  151-  443 (317.15/365.88)	KCQTipmsANVSAVRQLDAAL.NVISYIldrNACLlpsyfavneivkltseDRGGGPWPHWKLGqILSDfveTFRPTAQMVTLPGRRhLLPVV.GH.SSTTASAWRLTPTLkfPlHGPLPYDKeaqelqTDLLRYVLEQPYSRDMVCNMLSlNKQVKlRCLVLEEQLVE.....LIVLamersESEDTST.EG.......SVVSQLLWQHLS..SQLIFFVLFQFASF.PHMVSS...LYNKLKGSKLQKGRNHLMWV....L....LQFIS..GSIQKNP.LQDFLPVLKLYDLLYTEKEPLsvpdiekpystlsmavtciwihL
  446-  693 (324.70/219.25)	KAQT....DNVKLKRPVPYTLkNHMDFL...KQCL................TVKNQPMPNYRIA.LLCN...AYSTNTEYFSAPMSQ.LLEMIyGNgQSTTQLPGNITASA..P.SEPLPMDK......LDSLTVHAKMSLIHSIVTRVIK.HAHTK.NTVALAPALVEtysrlLVYM.....EIESLGI.KGfisqllpTVVKSRAWGILH..TLLEMFI.YRLHHIqPHYRVQ...LLSHLHTLVALTNQNQLHLC....VestaLRLINglGSTEVQPqLSRFLQEPKSLALLSNESEEL.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     320.51|     103|     295|     923|    1031|       2
---------------------------------------------------------------------------
  923- 1031 (164.32/149.65)	WHEKHMAFHRKYPeKFYYEGLQDLSSpSQHQYLPV..YFGNVCLRFLP.....VLDIVIHRFLELpsAQVSKSLENMLdHMGKLYKFHDRpVTYLY..NTLHY.YEKRLRD.RPALKRRL
 1216- 1329 (156.19/114.97)	WHHASIGQISILP.QFIKEQLKPVVH.TEEQFLFIchLVGPFLQRFYAertrcLLEFVVDLYEIL..EKVDKACEHLF.HMDSISDFLYH.IKYMFvgDGVKAeVDKIIFNlRPALKLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     353.19|     117|     358|     721|     856|       3
---------------------------------------------------------------------------
  721-  856 (174.21/181.87)	IMTTIMQHTPhgwsSHTIAC......FP.PAL....AEFFQQNPVPREEKTTLKRMVETEYRKWKSMNNEsDLIAHFSMQGtpplficIIWRCLlEDGRVSTTAYKVLERLGSKTLSQhlrtFADYLVFEFATSGG..GqQVQkC..VNAL
 1080- 1211 (178.98/127.87)	IVDTIAGKTP....SPFLNCdwrfneFPnPAAhalhATCIELMALPVASATVGSALMDTVLKNAAQVPRE.QIMSWMNAVG.......LILTAL.PDSYWMVINEKILFAVQTPILAN....FKPFEIFNFSTSHAvfG.EVQ.CsyVLAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11942 with Med23 domain of Kingdom Metazoa
Unable to open file!