<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11933

Description mediator of RNA polymerase II transcription subunit 1 isoform X1
SequenceMAALLGSLSAPAKSAPDSDDSEPGEKLGLLMERLRQKRSQLKSWGETSKMLRIAINDKRQQSTALEKVQLQKYMETLQKALKVNTVPALLERLETMAVQTGLKYTPSAMGCIIASDLFKVEVLFDGTGVFRDVRVAHCGRDSESCPEIQEILKAGNHSEFLEHLRGLVSMYQIGDKDKKLRIKGFMALTSLESDLNRVAQFQSSISGVSSYIHKSPLGILQPRCGGKPMRLTYFVAPYDLLDGKAKKSLPMTVEAITENNLGHNAEVCISPSSGHKLQTMPLMTINKTEGKSLPHFAAQTSLNSVTLPAQFILKLGKPIPVAVSILMKIQQTTGIQFVNMSQAQPLVNLLIQEVYGTKMDTPRKGISVKLPGQQHTYVINDGSAEDMMGIVVDQIPFTLPTNVPSILQSLRQQLLFNTLIASCVRGKSVEGTSHSLVFEVTPVSLQYITVAFEHPLHTSMATAELDLSDVTTVKCKLYTLSGDETICSDDYVCRVIQRCLSIPVTMRAIIRKVSSQIEKLRPPPAAQPTANMQNLLAKQIMDKRLSYFEATIRNPLLLNELKMNEFSTRENIIGPFTPGLMPNHPIGSQGPTSMYRFPNVMAGGPQYGNHYDGGGHGQSGLVTPEMESLEEKRERVNKNPMLASLLDQDTPSPDPQIQQQQVQQQQQQNSILSSLLGDQPPTPMAAPTKQRKKRMRRSTSTTDGGRSPGSSTGKSPKRKVSEAEEFENRLKEMEVDQSAGDPFDSSVGSSISNPALTSSQVYGDQVDPFSVPVESQIDKLKNSVDNFIKKESKSINSCQGSSELSMLLSDIETDTQVGGSMIRRPSSGDARPGSAHSLARSTSGASVEEILTNRTTPLDPDAFQGKDGGTFTPTQFLGEPGKVSRKFSKGSTESMEFNADLLNPDSSFADSLIENATDEMDLDTCDANAFGVGFNPVAIMASKMAAKVETADSQQGNGASKSPSRKTPVQRSNSRTNHNFERSNSLEEKPVETSNTPNKSLVMSLKQSELQSKVDSPQEALDLSKSSKDFTMNDETPGLKNDLGPSPLDLTADIEVAKITGSGGEMAASKGMELVSPLKIPAFAVSQRTGTGAKKERTLSNKSGKIPKDAKRRNSDREGGKRKKEDSGKEKTGKRRKTISSIEGHPQGDQIYSIEQAKKPTAIKITTSKLKSVKPSVDGSTNKMDLSKASVSAKPKVTVIPPMSSKKPESGQKGMMSPPVVNKSGQPVMSGKTPTTPSPTHKLLSSKISPTQFGKSPTIGRNSPSLKNLSGKASPMSRSPSVGGKSRKANNQVTVSKQDSKLMNKTPTIKLKPIALPANQPPGTGTTTSSASPGATGKQPFTPTTPTTPGKIKARKKSLSAVIDNLTKQSNSVVLPQTAEPGVEKKEEEKKKDDKTGLDVLKPDTTGFLSSYKIPKKVKSETPVTTSSAVTASQDKPSSTERMNVELKSADRNTSDSTSKTKSEKVLNAGNPSTKPVNITSSPGRAPLPPSRVGGSTSSSPRTFKPNFGTSGAPYSTNNVNSSKNNGDEINNRTSIGAKTNPVSTGAATRLDFTKPPASPPPSETLTQKPQKEIPLKSISEKDSVEKTHVSDSAAKSLQSKNVNGLNNNNNNNGKTGNGASLKSGVEKRRGLFDSIGFEPKTESTDKGKDSENRVNSIGGFTSEKQDSKQQSSYDGISNQSTSSFDMTLNSQKLGSSPRVSSSSSSSSSSSSQTSSSNLRSNHVVGNDSTNSPTSTSTVRPQQSDKDTDNIFKAPTPKPPESPSPAGTVLENNKRDDGSPAPKRIRIESQKPVLSPRSDASSPDNLIIDYPSTPKSSQQTGAVRSPTAKLGSESPAIGAIPQSPAEEAAMHSPAAVTLKSPAPAMPIKSPLPHAPSPSPSANNKSSSASRGTSPGDTACDLDDDLMDAALMN
Length1912
PositionMiddle
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.03
Grand average of hydropathy-0.650
Instability index55.85
Isoelectric point9.40
Molecular weight204705.31
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11933
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1700.30|     397|     404|    1035|    1437|       1
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  582-  967 (505.32/200.60)	PNHPIGSQ..GPTSMYRFPNVMAGGPQYGNhYDGGGHGQSglVTPEMESLEEK.RERVNKNP..MLASLLDQdTPSPDPQIQQQQVQQQQQ.QNSILSS....LLGDQPPTPMAAPTKQRKKRMRRSTSTTDGGRSPGSSTGKSPKRK...VSEAEEFENRLKEMEVDQSAGDP..FDSS..VGSSISN..PALTSSQVYGDQVDPfsvpvesqidklknsvdnfikkESKS..INS.CQGSSELSmLLSDIETD..TQVGGSMIRRP...SSGDA.RPGSAHSLA......RSTSGASVEEILTNRTTPLDPDAFQ...GKDGGTFTPTQFLGE.PGKVSRKFS..KGSTE........SME..FNADLLNPDSSFADSL...IENA...TDEMDLDTCDANAfgvgfNPVAIMASKMAAKvETADSQQGN................GASKSPSRKT
  968- 1238 (410.39/161.33)	PVQR..SNSRTNHNFERSNSLEEKPVETSN.TPNKSLVMS.lKQSELQSKVDSPQEALDLSKssKDFTMNDE.TPGL..............................................................................................................................................................KN.DLGPSPLD.LTADIEVAKITGSGGEMAASK...GMELV.SPLKIPAFAV...SQRTGTGAKKERTLSNKSGKIPKDAKRRNSDREGGKRKKEDSGKEKTGKRRKTISSIEGHPQGDQI...YSIEQAKKPTAIKITTSKLKSVKPSVDGS...TNKMDLSKASVSA.....KPKVTVIPPMSSK.KPESGQKGMMSPP...VVNKSGQPVMSGKTPTTPS
 1239- 1575 (469.73/196.70)	PTHKLLSSKISPTQFGKSPTIGRNSPSLKN.LSGKASPMS..RSPSVGGKSRKANNQVTVSK..QDSKLMNK.TPTIKLKPIALPANQPPG.TGTTTSSASPGATGKQPFTPTTPTTPGKIKARKKSLSAVIDNLTKQSNSVVLPQTAepGVEKKEEEKKKDDKTGLDVLKPDTTGFLSSykIPKKVKSetPVTTSSAVTASQDKP...................sstERMNveLKSaDRNTS..D.STSKTKSEKVLNAGN..PSTK...PVNITsSPGRAP.LPP...SRVGGSTSSSPRTF........................KPNFGTSGAPYSTNNVNS..SKNNGDEInnrTSIG.AKT..............NPVSTGA...ATRLDFTKPPASP.....PPSETL.....TQ.KP...QKEI...P......................
 1576- 1825 (314.86/121.80)	...........................LKS.ISEK..............................DS..VEK.T...HVSDSAAKSLQSKNvNGLNNNNNNNGKTG.................NGASLKS....................GV.....EKRR....GL....FDSIGF...................EPKTESTDKG.....................kDSEN..RVN.SIG.................GFTSEKQDSKqqsSYDGI.SNQSTSSFDMtlnSQKLGS...SPRVSSSSSSSSSSSSQTSSSNLRSNHVVGNDSTNSPTST..STVRPQQSDKDTDNI...FKAPTPKPPES............PSPAGTvleNNKRD....DGSP.....APKRIRI...ESQ.KPVLSPRSDASSPdnlIIDYPSTPKSSQQTGAVRS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      22|      24|    1833|    1855|       2
---------------------------------------------------------------------------
 1826- 1852 (31.29/12.91)	PTAklgsESPAiGAIP.QSPAEEAAMHS
 1853- 1878 (33.02/10.85)	PAA.vtlKSPA.PAMPiKSPLPHAPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.88|      58|     251|     248|     307|       3
---------------------------------------------------------------------------
  248-  307 (89.26/56.14)	SLPMTVEAITEnNLGHNAEVCISPSSGHKLQTMPLMTINKTEGKSLPHFAAqTSLNSVTL
  501-  558 (96.61/52.90)	SIPVTMRAIIR.KVSSQIEKLRPPPAAQPTANMQNLLAKQIMDKRLSYFEA.TIRNPLLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11933 with Med1 domain of Kingdom Metazoa
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