<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11933

Description mediator of RNA polymerase II transcription subunit 1 isoform X1
SequenceMAALLGSLSAPAKSAPDSDDSEPGEKLGLLMERLRQKRSQLKSWGETSKMLRIAINDKRQQSTALEKVQLQKYMETLQKALKVNTVPALLERLETMAVQTGLKYTPSAMGCIIASDLFKVEVLFDGTGVFRDVRVAHCGRDSESCPEIQEILKAGNHSEFLEHLRGLVSMYQIGDKDKKLRIKGFMALTSLESDLNRVAQFQSSISGVSSYIHKSPLGILQPRCGGKPMRLTYFVAPYDLLDGKAKKSLPMTVEAITENNLGHNAEVCISPSSGHKLQTMPLMTINKTEGKSLPHFAAQTSLNSVTLPAQFILKLGKPIPVAVSILMKIQQTTGIQFVNMSQAQPLVNLLIQEVYGTKMDTPRKGISVKLPGQQHTYVINDGSAEDMMGIVVDQIPFTLPTNVPSILQSLRQQLLFNTLIASCVRGKSVEGTSHSLVFEVTPVSLQYITVAFEHPLHTSMATAELDLSDVTTVKCKLYTLSGDETICSDDYVCRVIQRCLSIPVTMRAIIRKVSSQIEKLRPPPAAQPTANMQNLLAKQIMDKRLSYFEATIRNPLLLNELKMNEFSTRENIIGPFTPGLMPNHPIGSQGPTSMYRFPNVMAGGPQYGNHYDGGGHGQSGLVTPEMESLEEKRERVNKNPMLASLLDQDTPSPDPQIQQQQVQQQQQQNSILSSLLGDQPPTPMAAPTKQRKKRMRRSTSTTDGGRSPGSSTGKSPKRKVSEAEEFENRLKEMEVDQSAGDPFDSSVGSSISNPALTSSQVYGDQVDPFSVPVESQIDKLKNSVDNFIKKESKSINSCQGSSELSMLLSDIETDTQVGGSMIRRPSSGDARPGSAHSLARSTSGASVEEILTNRTTPLDPDAFQGKDGGTFTPTQFLGEPGKVSRKFSKGSTESMEFNADLLNPDSSFADSLIENATDEMDLDTCDANAFGVGFNPVAIMASKMAAKVETADSQQGNGASKSPSRKTPVQRSNSRTNHNFERSNSLEEKPVETSNTPNKSLVMSLKQSELQSKVDSPQEALDLSKSSKDFTMNDETPGLKNDLGPSPLDLTADIEVAKITGSGGEMAASKGMELVSPLKIPAFAVSQRTGTGAKKERTLSNKSGKIPKDAKRRNSDREGGKRKKEDSGKEKTGKRRKTISSIEGHPQGDQIYSIEQAKKPTAIKITTSKLKSVKPSVDGSTNKMDLSKASVSAKPKVTVIPPMSSKKPESGQKGMMSPPVVNKSGQPVMSGKTPTTPSPTHKLLSSKISPTQFGKSPTIGRNSPSLKNLSGKASPMSRSPSVGGKSRKANNQVTVSKQDSKLMNKTPTIKLKPIALPANQPPGTGTTTSSASPGATGKQPFTPTTPTTPGKIKARKKSLSAVIDNLTKQSNSVVLPQTAEPGVEKKEEEKKKDDKTGLDVLKPDTTGFLSSYKIPKKVKSETPVTTSSAVTASQDKPSSTERMNVELKSADRNTSDSTSKTKSEKVLNAGNPSTKPVNITSSPGRAPLPPSRVGGSTSSSPRTFKPNFGTSGAPYSTNNVNSSKNNGDEINNRTSIGAKTNPVSTGAATRLDFTKPPASPPPSETLTQKPQKEIPLKSISEKDSVEKTHVSDSAAKSLQSKNVNGLNNNNNNNGKTGNGASLKSGVEKRRGLFDSIGFEPKTESTDKGKDSENRVNSIGGFTSEKQDSKQQSSYDGISNQSTSSFDMTLNSQKLGSSPRVSSSSSSSSSSSSQTSSSNLRSNHVVGNDSTNSPTSTSTVRPQQSDKDTDNIFKAPTPKPPESPSPAGTVLENNKRDDGSPAPKRIRIESQKPVLSPRSDASSPDNLIIDYPSTPKSSQQTGAVRSPTAKLGSESPAIGAIPQSPAEEAAMHSPAAVTLKSPAPAMPIKSPLPHAPSPSPSANNKSSSASRGTSPGDTACDLDDDLMDAALMN
Length1912
PositionMiddle
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.03
Grand average of hydropathy-0.650
Instability index55.85
Isoelectric point9.40
Molecular weight204705.31
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11933
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1700.30|     397|     404|    1035|    1437|       1
---------------------------------------------------------------------------
  582-  967 (505.32/200.60)	PNHPIGSQ..GPTSMYRFPNVMAGGPQYGNhYDGGGHGQSglVTPEMESLEEK.RERVNKNP..MLASLLDQdTPSPDPQIQQQQVQQQQQ.QNSILSS....LLGDQPPTPMAAPTKQRKKRMRRSTSTTDGGRSPGSSTGKSPKRK...VSEAEEFENRLKEMEVDQSAGDP..FDSS..VGSSISN..PALTSSQVYGDQVDPfsvpvesqidklknsvdnfikkESKS..INS.CQGSSELSmLLSDIETD..TQVGGSMIRRP...SSGDA.RPGSAHSLA......RSTSGASVEEILTNRTTPLDPDAFQ...GKDGGTFTPTQFLGE.PGKVSRKFS..KGSTE........SME..FNADLLNPDSSFADSL...IENA...TDEMDLDTCDANAfgvgfNPVAIMASKMAAKvETADSQQGN................GASKSPSRKT
  968- 1238 (410.39/161.33)	PVQR..SNSRTNHNFERSNSLEEKPVETSN.TPNKSLVMS.lKQSELQSKVDSPQEALDLSKssKDFTMNDE.TPGL..............................................................................................................................................................KN.DLGPSPLD.LTADIEVAKITGSGGEMAASK...GMELV.SPLKIPAFAV...SQRTGTGAKKERTLSNKSGKIPKDAKRRNSDREGGKRKKEDSGKEKTGKRRKTISSIEGHPQGDQI...YSIEQAKKPTAIKITTSKLKSVKPSVDGS...TNKMDLSKASVSA.....KPKVTVIPPMSSK.KPESGQKGMMSPP...VVNKSGQPVMSGKTPTTPS
 1239- 1575 (469.73/196.70)	PTHKLLSSKISPTQFGKSPTIGRNSPSLKN.LSGKASPMS..RSPSVGGKSRKANNQVTVSK..QDSKLMNK.TPTIKLKPIALPANQPPG.TGTTTSSASPGATGKQPFTPTTPTTPGKIKARKKSLSAVIDNLTKQSNSVVLPQTAepGVEKKEEEKKKDDKTGLDVLKPDTTGFLSSykIPKKVKSetPVTTSSAVTASQDKP...................sstERMNveLKSaDRNTS..D.STSKTKSEKVLNAGN..PSTK...PVNITsSPGRAP.LPP...SRVGGSTSSSPRTF........................KPNFGTSGAPYSTNNVNS..SKNNGDEInnrTSIG.AKT..............NPVSTGA...ATRLDFTKPPASP.....PPSETL.....TQ.KP...QKEI...P......................
 1576- 1825 (314.86/121.80)	...........................LKS.ISEK..............................DS..VEK.T...HVSDSAAKSLQSKNvNGLNNNNNNNGKTG.................NGASLKS....................GV.....EKRR....GL....FDSIGF...................EPKTESTDKG.....................kDSEN..RVN.SIG.................GFTSEKQDSKqqsSYDGI.SNQSTSSFDMtlnSQKLGS...SPRVSSSSSSSSSSSSQTSSSNLRSNHVVGNDSTNSPTST..STVRPQQSDKDTDNI...FKAPTPKPPES............PSPAGTvleNNKRD....DGSP.....APKRIRI...ESQ.KPVLSPRSDASSPdnlIIDYPSTPKSSQQTGAVRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      22|      24|    1833|    1855|       2
---------------------------------------------------------------------------
 1826- 1852 (31.29/12.91)	PTAklgsESPAiGAIP.QSPAEEAAMHS
 1853- 1878 (33.02/10.85)	PAA.vtlKSPA.PAMPiKSPLPHAPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.88|      58|     251|     248|     307|       3
---------------------------------------------------------------------------
  248-  307 (89.26/56.14)	SLPMTVEAITEnNLGHNAEVCISPSSGHKLQTMPLMTINKTEGKSLPHFAAqTSLNSVTL
  501-  558 (96.61/52.90)	SIPVTMRAIIR.KVSSQIEKLRPPPAAQPTANMQNLLAKQIMDKRLSYFEA.TIRNPLLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11933 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IIGPFTPGLMPNHPIGSQGPTSMYRFPNVMAGGPQYGNHYDGGGHGQSGLVTPEMESLEEKRERVNKNPMLASLLDQDTPSPDPQIQQQQVQQQQQQNSILSSLLGDQPPTPMAAPTKQRKKRMRRSTSTTDGGRSPGSSTGKSPKRKVSEAEEFENRLKEMEVDQSAGDPFDSSVGSSISNPALTSSQVYGDQVDPFSVPVESQID
2) KMAAKVETADSQQGNGASKSPSRKTPVQRSNSRTNHNFERSNSLEEKPVETSNTPNKSLVMSLKQSELQSKVDSPQEALDLSKSSKDFTMNDETPGLKNDLGPSPLDLTADIEVAKITGSGGEMAASKGMELVSPLKIPAFAVSQRTGTGAKKERTLSNKSGKIPKDAKRRNSDREGGKRKKEDSGKEKTGKRRKTISSIEGHPQGDQIYSIEQAKKPTAIKITTSKLKSVKPSVDGSTNKMDLSKASVSAKPKVTVIPPMSSKKPESGQKGMMSPPVVNKSGQPVMSGKTPTTPSPTHKLLSSKISPTQFGKSPTIGRNSPSLKNLSGKASPMSRSPSVGGKSRKANNQVTVSKQDSKLMNKTPTIKLKPIALPANQPPGTGTTTSSASPGATGKQPFTPTTPTTPGKIKARKKSLSAVIDNLTKQSNSVVLPQTAEPGVEKKEEEKKKDDKTGLDVLKPDTTGFLSSYKIPKKVKSETPVTTSSAVTASQDKPSSTERMNVELKSADRNTSDSTSKTKSEKVLNAGNPSTKPVNITSSPGRAPLPPSRVGGSTSSSPRTFKPNFGTSGAPYSTNNVNSSKNNGDEINNRTSIGAKTNPVSTGAATRLDFTKPPASPPPSETLTQKPQKEIPLKSISEKDSVEKTHVSDSAAKSLQSKNVNGLNNNNNNNGKTGNGASLKSGVEKRRGLFDSIGFEPKTESTDKGKDSENRVNSIGGFTSEKQDSKQQSSYDGISNQSTSSFDMTLNSQKLGSSPRVSSSSSSSSSSSSQTSSSNLRSNHVVGNDSTNSPTSTSTVRPQQSDKDTDNIFKAPTPKPPESPSPAGTVLENNKRDDGSPAPKRIRIESQKPVLSPRSDASSPDNLIIDYPSTPKSSQQTGAVRSPTAKLGSESPAIGAIPQSPAEEAAMHSPAAVTLKSPAPAMPIKSPLPHAPSPSPSANNKSSSASRGTSPGDTACDLDDDLMDAALMN
3) QGSSELSMLLSDIETDTQVGGSMIRRPSSGDARPGSAHSLARSTSGASVEEILTNRTTPLDPDAFQGKDGGTFTPTQFLGEPGKVSRKFSKGSTESMEFNADLLNPDSSFADSLIENATDEMDL
572
943
799
778
1912
922










Molecular Recognition Features






MoRF SequenceStartStop




1) APKRIRIESQKPVLSPR
2) DQIYSIEQA
3) DSKLMNKTPTIKLKPIAL
4) EAAMHSPAAVTLKSPAPAMPIKS
5) EKRRGLFDSI
6) GEKLGLLMERLR
7) GFLSSYKIPKK
8) KIKARKKSLSAVID
9) LKIPAFA
10) LKSVK
11) LMDAALM
12) NKMDLSKASVSAK
13) PDNLIIDYPS
14) RLDFTK
1781
1149
1299
1847
1627
24
1407
1351
1078
1170
1905
1182
1803
1550
1797
1157
1316
1869
1636
35
1417
1364
1084
1174
1911
1194
1812
1555