<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11926
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MAEKAEDWRTQQFRQKVIIQIDEAVRHAGSPTSKSPYEMENHVFQKAKTRDEYLALVARLIIHVREMNSKKEKAAQQAAAGGAMMTGGMHPMGGGGQAPIQDPINALQNLAKTGVGTSMGPQQMAQGPMANRGQVPMMQQMMVRGMSQQQDVGRSPQVSQQQQSSSVPSPAVSSIQPVHSPANPFASPSPGPGSAMAPSPASRVSFGAPSPGGISVNTPGNPGSVGPAPSPALRSAEDQAYLDKLKQLSKYIEPLRRMINKIDKDEDRKKDLSKMKSLLEILSDSNRRLPMQTLLKCEQVLEKLELLSKPSSSSSTSVSSSSQGLKLSEQHMCQPLLDTVAQFVKSPTLNHTLERTFGPALDALHGPPIRGPSPPPKRFKPEEDKEGEVPNVIQGEIARLARRFKVDFDPMTRNGEKTLHFICKLDDKNLPSVPPLSITVPAGYPETSPECDTALGDYESTPFLQNVQKSLDISLTKMPNRYSITALLDTWEMSVRQACNPDHATQK |
Length | 507 |
Position | Tail |
Organism | Lingula unguis |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea>
Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.580 |
Instability index | 61.59 |
Isoelectric point | 8.99 |
Molecular weight | 55164.30 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11926
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 101.26| 24| 29| 168| 194| 1
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168- 191 (48.50/20.30) PSPAVSSI.QPVHSPA.NPFASPSPG
198- 212 (29.94/13.01) PSPA.SRV..........SFGAPSPG
335- 358 (22.82/ 6.52) ..PLLDTVaQFVKSPTlNHTLERTFG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.29| 26| 34| 89| 122| 2
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89- 122 (39.66/40.72) M..HPMGGGGQAPIqdpinaLQNLAKTG......VGTSmgPQ
124- 157 (41.63/22.63) MaqGPMANRGQVPM......MQQMMVRGmsqqqdVGRS..PQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.07| 18| 22| 262| 283| 3
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265- 282 (29.57/21.28) DEDRK...KDLSKMKSLLE...IL
284- 307 (18.51/ 6.90) DSNRRlpmQTLLKCEQVLEkleLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 73.02| 22| 22| 359| 380| 4
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359- 380 (43.37/27.46) PALDALHGPP..IRGP.SPPPKRFK
381- 405 (29.65/16.17) PEEDKEGEVPnvIQGEiARLARRFK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 142.77| 45| 219| 214| 261| 5
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214- 261 (66.24/44.74) ISVNTP.GNPgSVGPAPSPALRSAEDQAYLDKLkQLSKYIePLRRMINK
436- 481 (76.53/39.68) LSITVPaGYP.ETSPECDTALGDYESTPFLQNV.QKSLDI.SLTKMPNR
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