<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11925

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEKAEDWRTQQFRQKVIIQIDEAVRHAGSPTSKSPYEMENHVFQKAKTRDEYLALVARLIIHVREMNSKKEKAAQQAAAGGAMMTGGMHPMGGGGQAPIQDPINALQNLAKTGVGTSMGPQQMAQGPMANRGQVPMMQQMMVRGMSQQQDVGRSPQMTSPPVLSPLSRPSSQVQSPYSVQNTYGQVSQQQQSSSVPSPAVSSIQPVHSPANPFASPSPGPGSAMAPSPASRVSFGAPSPGGISVNTPGNPGSVGPAPSPALRSAEDQAYLDKLKQLSKYIEPLRRMINKIDKDEDRKKDLSKMKSLLEILSDSNRRLPMQTLLKCEQVLEKLELLSKPSSSSSTSVSSSSQGLKLSEQHMCQPLLDTVAQFVKSPTLNHTLERTFGPALDALHGPPIRGPSPPPKRFKPEEDKEGEVPNVIQGEIARLARRFKVDFDPMTRNGEKTLHFICKLDDKNLPSVPPLSITVPAGYPETSPECDTALGDYESTPFLQNVQKSLDISLTKMPNRYSITALLDTWEMSVRQACNPDHATQK
Length536
PositionTail
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.582
Instability index64.08
Isoelectric point9.06
Molecular weight58282.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11925
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      18|      22|     291|     312|       2
---------------------------------------------------------------------------
  294-  311 (29.57/20.68)	DEDRK...KDLSKMKSLLE...IL
  313-  336 (18.51/ 6.53)	DSNRRlpmQTLLKCEQVLEkleLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.77|      16|      56|      84|      99|       3
---------------------------------------------------------------------------
   84-   99 (34.49/19.80)	M....MTGGMHPMGGGGQAP
  119-  136 (22.76/10.52)	MgpqqMAQG..PMANRGQVP
  141-  156 (29.52/15.87)	M....MVRGMSQQQDVGRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.92|      33|      60|     165|     203|       5
---------------------------------------------------------------------------
  165-  203 (56.41/35.04)	SPLSRPSSQVQSPYSVQ.NTYGqvsqqqQSSSV...PSPAVSS
  228-  264 (54.51/24.29)	SPASRVSFGAPSPGGISvNTPG......NPGSVgpaPSPALRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.15|      22|      22|     388|     409|       6
---------------------------------------------------------------------------
  364-  387 (27.60/11.87)	PLLDTV.AQF..VKSP.TlnhTLERTFG
  388-  409 (41.34/21.19)	PALDALHGPP..IRGP.S...PPPKRFK
  410-  434 (27.22/11.62)	PEEDKEGEVPnvIQGEiA...RLARRFK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11925 with Med15 domain of Kingdom Metazoa
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