<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11916

Description cyclin-dependent kinase 8 isoform X1
SequenceMVDYDYKVKCASERQKVEDEFEYEGCKVGRGTYGHVYKARRKNSDGREYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRAAKANKKPVNVPRNFVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHPTLMKDFKKSSYVNCTLTKYMEKHKVHPDSKAFRLLQKLLTMDPTKRITSEQAMQDAYFMEDPSPCPDVFEGLPIPYPKREFITDDEPTNDNEKSDNASKATGGNDQSSSHGQPPAKRVRVMQPNTNNGTMVSNEYQRNVHGMPGNQGQQHSYSSTQSTQGTNSTVYGQTRF
Length448
PositionKinase
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.10
Grand average of hydropathy-0.683
Instability index39.53
Isoelectric point8.60
Molecular weight51522.99
Publications
PubMed=26383154

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11916
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.85|      32|      36|     297|     332|       1
---------------------------------------------------------------------------
  297-  332 (46.68/37.98)	MEKHKVHPDskAFRLLQklLTMDPTKRITSEQAMQD
  336-  367 (61.17/36.96)	MEDPSPCPD..VFEGLP..IPYPKREFITDDEPTND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.79|      20|      40|     368|     387|       2
---------------------------------------------------------------------------
  368-  387 (33.88/18.03)	NEKSDNASKATGGNDQSSSH
  410-  429 (38.91/21.54)	NEYQRNVHGMPGNQGQQHSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      36|     151|     165|       3
---------------------------------------------------------------------------
  151-  165 (26.77/16.56)	DLKPANILVMGEGPE
  189-  203 (28.67/18.19)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11916 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VFEGLPIPYPKREFITDDEPTNDNEKSDNASKATGGNDQSSSHGQPPAKRVRVMQPNTNNGTMVSNEYQRNVHGMPGNQGQQHSYSSTQSTQGTNSTVYGQTRF
345
448










Molecular Recognition Features






MoRF SequenceStartStop




NANANA