<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11912

Description mediator of RNA polymerase II transcription subunit 25 isoform X2
SequenceMVAGFSGQDPVSDVVLVVEATANLGAYFDDLLKSYVLPTLEHFDGGPPSEIDYGFDYNCTLYSLVMFGAADCGPDPAARCRAPTTSTSELLSWIDGVQFVGGGGEERSFVAEGLSTALQIFDDYNKVRDQNTQTNKYCILVCNSPPYQIPSQESIKYSGYNAEDLAHMMGQRGINLSVISPRKIPSLCRLYDKANHDHSPPKDYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAATVSGSQTLYKSLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRAGAKDLWTGALEWQEKTKTGNTTDPGAKIIRSLPCKVYITQGEQEVNASIWPNKLQMQLIPQAILQSLQSLFRNSRTVSFQFANTDKEAIKSLYKILSQGFAGYIHFPTMSQVDVRVVLLLYSTKMKKFVGLIPNDQNSFINGIKIAVTKHKTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQAATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQLQQVQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQAQQQRLHQQQLLMQQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
Length1139
PositionUnknown
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.688
Instability index68.90
Isoelectric point9.15
Molecular weight123611.11
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11912
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     352.52|      39|      39|    1019|    1057|       1
---------------------------------------------------------------------------
  426-  460 (49.83/10.11)	QQQQQQQGMQPG..PGP....P.............LSQQPGLHMPPVSQPLPMA...
  592-  618 (43.28/ 7.40)	TSQQQQQQPQQP..GGP....Q............NVM......VSQQNMM......A
  619-  645 (40.59/ 6.28)	QSQNNMMPAQNN..MGP...........................SQSDMMTQGG.MY
  880-  928 (52.07/11.04)	QPPQSQPGMQTP..QQP.....llgqnsqfsqaaTLTTQQQQQLQPQQQSQQVAQ.Q
 1000- 1042 (43.85/ 7.64)	QAKEKQFQTQRQ..IDEaraqH............TLVQQRQQQLQQVQQQQQRLQLQ
 1043- 1083 (56.30/12.79)	QQQQQQQQQQNP..SNP.qlkQ............ILINQQQQQAQQQRLHQQQL.LM
 1084- 1124 (66.59/17.05)	QQQQQQQQQQLPrgPGP....Q............GMGQGMGQPGMQQSGMGQMGQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.94|      22|      23|     521|     543|       2
---------------------------------------------------------------------------
  519-  541 (35.63/13.57)	MTsQPNMMTPQQQQHMMTSQSNL
  949-  970 (33.31/ 8.60)	MP.GPGPQQPQQRQVSNVNQMGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.56|      40|      54|     144|     185|       3
---------------------------------------------------------------------------
  144-  185 (67.41/41.85)	SPP..YQIPSQESIKYSGYNAEDLAHMMGQRGINLSVIspRKIP
  199-  240 (68.15/36.47)	SPPkdYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSI..QKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     313.67|      45|     102|     545|     589|       4
---------------------------------------------------------------------------
  251-  292 (39.67/ 8.69)	.ASSVLASAPTAATVSGSQ.TL..YKS...LGDSgfRIPVPA.............SVS.........AQQP
  306-  347 (55.32/15.65)	TTRPTGPVTSQPPLMSQIRSPI..SQTQ...TSS..APGPPH.............ISS.........GPGT
  349-  395 (43.15/10.24)	.....LQQHPTSIAPPASQPT....SAASGMGLQ..RHPPPN.............VLAstqaqqlttTLKG
  461-  498 (42.94/10.15)	........SYQSQLPTQSQPT.tsLTSATGMGTV..MSSQAS.............HQN.........FQGG
  545-  589 (81.45/27.27)	QASNMMMTSSQSNIMPSSQPNL..MSSQMNMGNS..QISQPG.............MMS.........TQGG
  646-  693 (51.13/13.79)	QNPNM..QSGLRN......PGP..PQSRMPM.QS..NV.QPGvpmgqmanqpldmLMA.........GPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.87|      13|      26|     795|     807|       8
---------------------------------------------------------------------------
  795-  807 (23.24/15.80)	LYKILSQGFAGYI
  823-  835 (22.63/15.18)	LYSTKMKKFVGLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11912 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQAATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQL
2) QQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
3) QQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQ
4) RGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAA
5) SLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRA
857
1084
1033
215
273
1029
1139
1067
262
703










Molecular Recognition Features






MoRF SequenceStartStop




1) QPFGDGFDLESLL
1127
1139