<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11911

Description mediator of RNA polymerase II transcription subunit 25 isoform X4
SequenceMVAGFSGQDPVSDVVLVVEATANLGAYFDDLLKSYVLPTLEHFDGGPPSEIDYGFDYNCTLYSLVMFGAADCGPDPAARCRAPTTSTSELLSWIDGVQFVGGGGEERSFVAEGLSTALQIFDDYNKVRDQNTQTNKYCILVCNSPPYQIPSQESIKYSGYNAEDLAHMMGQRGINLSVISPRKIPSLCRLYDKANHDHSPPKDYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRAGAKDLWTGALEWQEKTKTGNTTDPGAKIIRSLPCKVYITQGEQEVNASIWPNKLQMQLIPQAILQSLQSLFRNSRTVSFQFANTDKEAIKSLYKILSQGFAGYIHFPTMSQVDVRVVLLLYSTKMKKFVGLIPNDQNSFINGIKIAVTKHKTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQAATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRIPATMMGGPPLPGPPAVGPPSVPSGMMGPQQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQLQQVQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQAQQQRLHQQQLLMQQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
Length1126
PositionUnknown
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.697
Instability index69.56
Isoelectric point9.10
Molecular weight122203.85
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11911
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     441.47|      39|      39|    1006|    1044|       1
---------------------------------------------------------------------------
  391-  426 (51.94/ 9.80)	MQPG.P...GP.......P.L..SQQPGL...HMPPVSQPLPMASYQSQLPTQ
  471-  509 (48.35/ 8.41)	GQSGMM..TSQ.......PNM..MTPQQQ...QHMMTSQSNLMSSQASNMMMT
  555-  600 (42.60/ 6.18)	QQPQQP..GGPqnvmvsqQNM..MAQSQNnmmPAQNNMGPSQS.DMMTQ..GG
  601-  639 (47.20/ 7.96)	MYQ.NP..NMQ.......SGLrnPGPPQS...RMPMQSNVQPGVPMG.QMANQ
  835-  872 (55.93/11.35)	V.QQPP..QSQ.......PGM..QTPQQP...LLGQNSQFSQAATLTTQQQQQ
  897-  931 (44.32/ 6.85)	ADQFNP..SGP.....mpGPG..PQQPQQ...RIPATMMGGPPL......PGP
 1003- 1035 (49.51/ 8.86)	RAQ...............HTL..VQQRQQ...QLQQVQQQQQRLQLQQQQQQQ
 1036- 1076 (53.46/10.39)	QQQQNP..SNP....qlkQIL..INQQQQ...QAQQQRLHQQQL.LMQQQQQQ
 1077- 1114 (48.17/ 8.34)	QQQQLPrgPGP.......QGM..GQGMGQ...PGMQQSGMGQMGQLGQSQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.66|      19|      20|     224|     242|       2
---------------------------------------------------------------------------
  225-  246 (26.10/ 7.81)	SPGGDKIQDKSIQKLPAKvgsP
  247-  265 (27.56/ 8.67)	AAGSEASVSQSSAPQPTT...R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.18|      17|      56|     144|     160|       3
---------------------------------------------------------------------------
  144-  160 (32.83/20.06)	SPP..YQIPSQESIKYSGY
  179-  193 (20.62/ 9.49)	ISP..RKIPSLCRL.YDK.
  199-  217 (25.74/13.93)	SPPkdYTIDPRHLVLLRGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.20|      24|      72|     444|     467|       5
---------------------------------------------------------------------------
  440-  463 (38.79/11.96)	GTVMSSQASHQNFQGGGMKAPPQQ
  531-  554 (45.41/15.62)	GNSQISQPGMMSTQGGMMTSQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      13|      49|     883|     895|       6
---------------------------------------------------------------------------
  883-  895 (26.02/ 9.54)	AQQPQSQQSQMMG
  933-  945 (25.14/ 8.91)	AVGPPSVPSGMMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.62|      53|     309|     323|     384|       7
---------------------------------------------------------------------------
  323-  375 (93.05/30.04)	AAS..GMGLQRH.PPPNVLASTQA...QQLTTTLKGQNA.KEVTK...MILEQTKPGN........IR..PS.S
  646-  695 (56.67/14.17)	AGP..GGGLLDN.PASRAGAK......DLWTGALEWQ..............EKTKTGNttdpgakiIRslPC.K
  706-  770 (51.90/19.86)	NASiwPNKLQMQlIPQAILQSLQSlfrNSRTVSFQFANTdKEAIKslyKILSQGFAGY........IH.fPTmS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.83|      13|      19|     967|     983|      10
---------------------------------------------------------------------------
  967-  983 (15.35/16.53)	QERQANLSTipmlQRAL
  987-  999 (21.48/10.13)	QAKEKQFQT....QRQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11911 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQAATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRIPATMMGGPPLPGPPAVGPPSVPSGMMGPQQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQL
2) QQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
3) RHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRA
4) VQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQ
814
1071
209
1019
1016
1126
660
1054










Molecular Recognition Features






MoRF SequenceStartStop




1) QPFGDGFDLESLL
1114
1126