<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11910

Description mediator of RNA polymerase II transcription subunit 25 isoform X5
SequenceMVAGFSGQDPVSDVVLVVEATANLGAYFDDLLKSYVLPTLEHFDGGPPSEIDYGFDYNCTLYSLVMFGAADCGPDPAARCRAPTTSTSELLSWIDGVQFVGGGGEERSFVAEGLSTALQIFDDYNKVRDQNTQTNKYCILVCNSPPYQIPSQESIKYSGYNAEDLAHMMGQRGINLSVISPRKIPSLCRLYDKANHDHSPPKDYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAATVSGSQTLYKSLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRAGAKDLWTGALEWQEKTKTGNTTDPGAKIIRSLPCKVYITQGEQEVNASIWPNKLQMQLIPQAILQSLQSLFRNSRTVSFQFANTDKEAIKSLYKILSQGFAGYIHFPTMSQVDVRVVLLLYSTKMKKFVGLIPNDQNSFINGIKIAVTKHKTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQAATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQLQQVQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQAQQQRLHQQQLLMQQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
Length1113
PositionUnknown
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.694
Instability index69.95
Isoelectric point9.20
Molecular weight120910.15
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11910
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     391.86|      40|      40|     992|    1031|       1
---------------------------------------------------------------------------
  523-  562 (45.15/ 6.49)	PNMMTPQQQQHMMT...SQSNlmSS..QA..........S..NMMMTS..SQSNIMPSS
  563-  602 (54.82/ 9.79)	QPNLMSSQMNMGNS...QISQ..PGmmST..........Q..GGMMTSQQQQ.QQ.PQQ
  606-  645 (56.28/10.29)	PQNVMVSQQNMMAQ...SQNN..MM..PA..........Q..NNMGPSQSDMMTQGGMY
  862-  902 (53.16/ 9.23)	QQQ..LQQRGMMNQmagGVQQ..PP..QS..........Q..PGMQTPQQPLLGQNSQF
  929-  966 (62.55/12.43)	PQ..SQQSQMMGQA...DQFN..PS..GP..........M..PGPGPQQPQQRSTIPML
 1010- 1051 (58.87/11.18)	QQRLQLQQQQQQQQ...QQQN..PS..NP..........QlkQILINQQQQQAQQQRLH
 1052- 1100 (61.03/11.92)	QQQL.LMQQQQQQQ...QQQL..PR..GPgpqgmgqgmgQ..PGMQQSGMGQMGQLGQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     477.44|      99|      99|     240|     338|       3
---------------------------------------------------------------------------
  144-  236 (78.48/21.36)	........SP.............pyQIPSQESIKYSGYNA......EDLA...HMMGQRGI.NLSV......ISPRKiPSlcrlyDKANHDHSPPKDyT......IDPRHLVllrgyslQERPP......SPgGDKI..QDKS...I
  237-  335 (159.25/52.14)	QKLPAKVGSP...............AAGSASSVLASAPTAATVSGSQTLY...KSLGDSGF.RIPVP...ASVSAQQ.PQ.....EASVSQSSAPQP.T......TRPTGPV.......TSQPPLMSQIRSP.ISQT..QTSS...A
  336-  435 (128.22/40.31)	PGPPHISSGP....................GTMLQQHPTSIAPPASQPTS...AASG.MGLqRHPPPnvlASTQAQQ..L.....TTTLKGQNAKEV.TkmileqTKP.GNI.........RPS..SQFTQQ.LQQQ..QQQQqgmQ
  436-  500 (67.57/17.20)	PGP....GPPlsqqpglhmppvsqpL...........PMASY....QS..............QLP........................TQS...QP.T......TSLTS.A.......TGMGTVMS...SQ.ASHQnfQGGG...M
  657-  701 (43.91/ 8.18)	PGPPQ.SRMP..............mQSNVQPGV....PMGQM..ANQPLDmlmAGPG.GGL..LDNP...AS...........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.43|      15|      86|     907|     921|       4
---------------------------------------------------------------------------
  907-  921 (28.33/ 9.97)	TLTTQQQQQLQP.QQQ
  994- 1009 (23.10/ 6.49)	TLVQQRQQQLQQvQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.87|      13|      25|     795|     807|       5
---------------------------------------------------------------------------
  795-  807 (23.24/16.22)	LYKILSQGFAGYI
  823-  835 (22.63/15.59)	LYSTKMKKFVGLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.56|      10|      15|     967|     976|       6
---------------------------------------------------------------------------
  967-  976 (15.53/ 7.81)	QRALAAAQAK
  983-  992 (17.04/ 9.23)	QRQIDEARAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11910 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQ
2) QLQQQQQQQQQQQNPSNPQLKQILINQQQQQ
3) QQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQ
4) QQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
5) RGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAA
6) SLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRA
906
1014
857
1058
215
273
1001
1044
904
1113
262
703










Molecular Recognition Features






MoRF SequenceStartStop




1) LKQIL
2) QPFGDGFDLESLL
1033
1101
1037
1113