<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11909

Description mediator of RNA polymerase II transcription subunit 25 isoform X6
SequenceMVAGFSGQDPVSDVVLVVEATANLGAYFDDLLKSYVLPTLEHFDGGPPSEIDYGFDYNCTLYSLVMFGAADCGPDPAARCRAPTTSTSELLSWIDGVQFVGGGGEERSFVAEGLSTALQIFDDYNKVRDQNTQTNKYCILVCNSPPYQIPSQESIKYSGYNAEDLAHMMGQRGINLSVISPRKIPSLCRLYDKANHDHSPPKDYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAATVSGSQTLYKSLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRAGAKDLWTGALEWQEKTKTGNTTDPGAKIIRSLPCKVYITQGEQEVNASIWPNKLQMQLIPQAILQSLQSLFRNSRTVSFQFANTDKEAIKSLYKILSQGFAGYIHFPTMSQVDVRVVLLLYSTKMKKFVGLIPNDQNSFINGIKIAVTKHKTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQMMGQADQFNPSGPMPGPGPQQPQQRQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQLQQVQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQAQQQRLHQQQLLMQQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
Length1097
PositionUnknown
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.663
Instability index66.52
Isoelectric point9.15
Molecular weight118935.16
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11909
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     305.65|      40|      40|     976|    1015|       1
---------------------------------------------------------------------------
  550-  591 (45.02/ 7.02)	MMT.SSQSNIMPSsqpNL..........M..SSQMNMGNSQISQPGMMSTQGG...MM
  592-  633 (55.49/10.77)	TSQQQQQQPQQPG...GP..........Q..NVMV.SQQNMMAQSQNNMMPAQnnmGP
  855-  889 (54.03/10.24)	TMQQMKMQQQL......Q..........Q..RGMMNQMAGGVQQPPQ..SQPG...MQ
  963- 1000 (45.08/ 7.04)	..QFQTQRQIDEA...RA..........Q..HTLVQQRQQQLQQVQQQQQRLQ...LQ
 1001- 1041 (60.73/12.64)	QQQQQQQQQQNPS...NP..........QlkQILINQQQQQAQQQRLHQQQL....LM
 1042- 1085 (45.31/ 7.13)	QQQQQQQQQQLPR...GPgpqgmgqgmgQ..PGMQQSGMGQMGQLGQSQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     338.39|      58|      58|     434|     491|       2
---------------------------------------------------------------------------
  316-  351 (39.40/ 7.77)	QPPL.MSQIRSPI......SQTQTSSAP...........G......................pPhissGP..GTMLQQ
  352-  419 (62.78/18.09)	HPTSIAPPASQP...TSAASGMGLQRHPPPNVlasTQAQQLTTTLKGQNAkevtkmileqTK.P....GN..IRPSSQ
  445-  505 (95.39/32.49)	QPGLHMPPVSQPLPMASYQSQLPTQSQPTTSL...TSATGMGTVMSSQAS.......hqnFQ.G....GGmkAPP..Q
  506-  547 (54.31/14.35)	QGGM.MVGGGQSGMMTS.QPNMMTPQQQQHMM...TSQSNL...MSSQAS............................
  634-  663 (41.52/ 8.71)	..............S...QSDMMTQG....GM...YQNPNM......QSG..........LR......NP..GPPQSR
  693-  746 (45.00/10.24)	.GGLLDNPASRAGAKDLWTGALEWQEKTKTGN...TTDPGAKIIRS........lpckvyIT.Q....G.......EQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.56|      40|      54|     144|     185|       4
---------------------------------------------------------------------------
  144-  185 (67.41/38.98)	SPP..YQIPSQESIKYSGYNAEDLAHMMGQRGINLSVIspRKIP
  199-  240 (68.15/33.95)	SPPkdYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSI..QKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.88|      22|     126|     290|     315|       5
---------------------------------------------------------------------------
  246-  267 (34.05/13.32)	PAAGSAS......SV....LASAPTAATVSGS
  269-  300 (24.83/ 7.97)	TLYKSLGdsgfriPVpasvSAQQPQEASVSQS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11909 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQMMGQADQFNPSGPMPGPGPQQPQQRQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQL
2) QQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
3) QQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQ
4) RGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAA
5) SLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRA
857
1042
991
215
273
987
1097
1025
262
703










Molecular Recognition Features






MoRF SequenceStartStop




1) QPFGDGFDLESLL
1085
1097