<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11908

Description mediator of RNA polymerase II transcription subunit 25 isoform X1
SequenceMVAGFSGQDPVSDVVLVVEATANLGAYFDDLLKSYVLPTLEHFDGGPPSEIDYGFDYNCTLYSLVMFGAADCGPDPAARCRAPTTSTSELLSWIDGVQFVGGGGEERSFVAEGLSTALQIFDDYNKVRDQNTQTNKYCILVCNSPPYQIPSQESIKYSGYNAEDLAHMMGQRGINLSVISPRKIPSLCRLYDKANHDHSPPKDYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAATVSGSQTLYKSLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRAGAKDLWTGALEWQEKTKTGNTTDPGAKIIRSLPCKVYITQGEQEVNASIWPNKLQMQLIPQAILQSLQSLFRNSRTVSFQFANTDKEAIKSLYKILSQGFAGYIHFPTMSQVDVRVVLLLYSTKMKKFVGLIPNDQNSFINGIKIAVTKHKTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQAATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRIPATMMGGPPLPGPPAVGPPSVPSGMMGPQQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQLQQVQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQAQQQRLHQQQLLMQQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
Length1169
PositionUnknown
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.668
Instability index68.99
Isoelectric point9.15
Molecular weight126419.48
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11908
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     371.17|      39|      39|    1049|    1087|       1
---------------------------------------------------------------------------
  488-  530 (45.40/ 7.15)	SQASHQNFQGGGMKAPPQQGgmmvGGGQSGMM..TSQ.......PNMMTPQQ
  576-  621 (51.22/ 9.39)	SQISQPGMMSTQGGMMTSQQ....QQQQPQQP..GGPqnvmvsqQNMMAQSQ
  857-  893 (59.15/12.46)	QQMKMQQQLQQR.GMMNQMA....GGV.QQPP..QSQ.......PGMQTPQQ
  920-  958 (53.55/10.29)	QQSQQVAQQPQ..SQQSQMM....GQADQFNP..SGP.....mpGPGPQQPQ
  959-  989 (44.55/ 6.82)	QRIPATMMGGPPL......P....GPPAVGPP..SVP.......SGMMG..P
 1057- 1098 (58.18/12.08)	QQLQQVQQQQQRLQLQQQQQ....QQQQQQNP..SNP....qlkQILINQQQ
 1099- 1138 (59.12/12.44)	QQAQQQRLHQQQL.LMQQQQ....QQQQQQLPrgPGP.......QGMGQGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.76|      42|      56|     144|     186|       3
---------------------------------------------------------------------------
  163-  219 (52.49/30.16)	EDLAHMMGQRGINLSVIsPRKIPSlcrlydkanhdhSPPkdYTIDPRHLVLLRGYSL
  220-  261 (56.21/28.60)	QERPPSPGGDKIQDKSI..QKLPA.........kvgSP....AAGSASSVLASAPTA
  268-  300 (40.06/17.76)	QTLYKSLGDSGFRIPV..P................aSVS..AQQPQEASVSQS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.20|      33|      33|     410|     442|       5
---------------------------------------------------------------------------
  410-  442 (62.47/20.18)	KPGNIRPSSQ......FTQQLQQQQQQQQGMQ......PGPGPPL
  662-  695 (32.33/ 6.51)	..SRMPMQSN......VQPGVPM...GQMANQpldmlmAGPGGGL
  698-  731 (34.40/ 7.45)	NP.....ASRagakdlWTGALEWQEKTKTGNT......TDPGAKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.76|      10|      56|     565|     574|       6
---------------------------------------------------------------------------
  565-  574 (20.27/ 6.40)	NLMSSQMNMG
  623-  632 (21.49/ 7.22)	NMMPAQNNMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.15|      17|      57|     302|     318|       7
---------------------------------------------------------------------------
  302-  318 (35.10/15.54)	APQPTTRPTG.PVTSQPP
  360-  377 (24.74/ 8.16)	ASQPTSAASGmGLQRHPP
  453-  467 (23.32/ 7.15)	VSQPL..PMA.SYQSQLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.55|      20|     150|     990|    1009|       9
---------------------------------------------------------------------------
  990- 1009 (31.27/13.97)	QQVSNVNQMGMAGGGLTIS...D
 1011- 1033 (21.62/ 7.23)	ERQANLSTIPMLQRALAAAqakE
 1034- 1053 (28.67/12.16)	KQFQTQRQIDEARAQHTLV...Q
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11908 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQPLLGQNSQFSQAATLTTQQQQQLQPQQQSQQVAQQPQSQQSQMMGQADQFNPSGPMPGPGPQQPQQRIPATMMGGPPLPGPPAVGPPSVPSGMMGPQQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQL
2) QQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
3) RGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAA
4) SLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRA
5) VQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQ
857
1114
215
273
1062
1059
1169
262
703
1097










Molecular Recognition Features






MoRF SequenceStartStop




1) QPFGDGFDLESLL
1157
1169