<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11907

Description mediator of RNA polymerase II transcription subunit 25 isoform X8
SequenceMVAGFSGQDPVSDVVLVVEATANLGAYFDDLLKSYVLPTLEHFDGGPPSEIDYGFDYNCTLYSLVMFGAADCGPDPAARCRAPTTSTSELLSWIDGVQFVGGGGEERSFVAEGLSTALQIFDDYNKVRDQNTQTNKYCILVCNSPPYQIPSQESIKYSGYNAEDLAHMMGQRGINLSVISPRKIPSLCRLYDKANHDHSPPKDYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAATVSGSQTLYKSLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRAGAKDLWTGALEWQEKTKTGNTTDPGAKIIRSLPCKVYITQGEQEVNASIWPNKLQMQLIPQAILQSLQSLFRNSRTVSFQFANTDKEAIKSLYKILSQGFAGYIHFPTMSQVDVRVVLLLYSTKMKKFVGLIPNDQNSFINGIKIAVTKHKTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQMMGQADQFNPSGPMPGPGPQQPQQRSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQLQQVQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQAQQQRLHQQQLLMQQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
Length1071
PositionUnknown
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.668
Instability index67.56
Isoelectric point9.20
Molecular weight116234.20
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11907
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     323.49|      39|      39|     951|     989|       1
---------------------------------------------------------------------------
  427-  469 (48.16/ 8.94)	QQQQ.QQGMQ.P.GP...GpPLSQQPGLHMppvS.QPlPMAS....Y..QSQ..LpTQ
  593-  633 (57.01/12.35)	SQQQ.QQQPQQPGGP...QnVMVSQQNMMA...QsQN.NMMP....A..QNN..M.GP
  857-  891 (49.14/ 9.32)	..QQ.MKMQQQLQQR...G..MMNQMAGGV...Q.QP.PQSQ....P..GMQ....TP
  892-  930 (43.35/ 7.09)	QQMMgQADQFNPSGP...M.P..G...PGP...Q.QP.QQRS....TipMLQraL.AA
  976- 1016 (59.02/13.12)	QQQQ.QQQQQNPSNPqlkQ.ILINQQQQQA...Q.QQ.RLHQ....Q..QL...L.MQ
 1017- 1057 (66.80/16.12)	QQQQ.QQQQQLPRGP...G.P..QGMGQGM...G.QP.GMQQsgmgQ..MGQ..L.GQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.39|      23|      23|     521|     543|       2
---------------------------------------------------------------------------
  513-  533 (36.35/12.31)	..GGQSGMMTSQ.PNM.MTPQ.QQQH
  534-  558 (30.76/ 8.91)	MMTSQSNLMSSQaSNMmMTSS.QSNI
  559-  582 (36.27/12.26)	MPSSQPNLMSSQ.MNM.GNSQiSQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     211.41|      32|      32|     298|     329|       3
---------------------------------------------------------------------------
  254-  285 (36.86/12.88)	VLASAPTAAT.VSGSQTLYKSLG......dSGFRIPVPA
  298-  329 (58.18/25.20)	SQSSAPQPTTRPTGPVTSQPPLM.......SQIRSPISQ
  331-  356 (43.50/16.71)	QTSSAPGPPHISSGPGT.....M.......LQ.QHPTSI
  357-  379 (38.16/13.63)	A.PPASQP........TSAASGM.......GLQRHPPPN
  382-  419 (34.71/11.63)	ASTQAQQLTTTLKGQNAKEVTKMileqtkpGNIR.PSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.63|      14|      15|     642|     655|       4
---------------------------------------------------------------------------
  642-  655 (25.79/11.12)	GGMYQNPNMQSGLR
  658-  671 (20.85/ 7.15)	GPPQSRMPMQSNVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.56|      40|      54|     144|     185|       5
---------------------------------------------------------------------------
  144-  185 (67.41/41.00)	SPP..YQIPSQESIKYSGYNAEDLAHMMGQRGINLSVIspRKIP
  199-  240 (68.15/35.70)	SPPkdYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSI..QKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.25|      15|      15|     941|     955|       6
---------------------------------------------------------------------------
  941-  955 (24.02/ 9.91)	QRQIDEARAQHTLVQ
  958-  972 (24.23/10.07)	QQQLQQVQQQQQRLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.96|      10|      16|     673|     683|       9
---------------------------------------------------------------------------
  673-  683 (15.11/ 9.21)	GvPMGQMANQP
  690-  699 (18.85/ 7.82)	G.PGGGLLDNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11907 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQMMGQADQFNPSGPMPGPGPQQPQQRSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQL
2) QQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
3) RGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAA
4) SLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRA
5) VQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQ
857
1016
215
273
964
961
1071
262
703
1002










Molecular Recognition Features






MoRF SequenceStartStop




1) QPFGDGFDLESLL
1059
1071