<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11906

Description mediator of RNA polymerase II transcription subunit 25 isoform X3
SequenceMVAGFSGQDPVSDVVLVVEATANLGAYFDDLLKSYVLPTLEHFDGGPPSEIDYGFDYNCTLYSLVMFGAADCGPDPAARCRAPTTSTSELLSWIDGVQFVGGGGEERSFVAEGLSTALQIFDDYNKVRDQNTQTNKYCILVCNSPPYQIPSQESIKYSGYNAEDLAHMMGQRGINLSVISPRKIPSLCRLYDKANHDHSPPKDYTIDPRHLVLLRGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAATVSGSQTLYKSLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRAGAKDLWTGALEWQEKTKTGNTTDPGAKIIRSLPCKVYITQGEQEVNASIWPNKLQMQLIPQAILQSLQSLFRNSRTVSFQFANTDKEAIKSLYKILSQGFAGYIHFPTMSQVDVRVVLLLYSTKMKKFVGLIPNDQNSFINGIKIAVTKHKTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQMMGQADQFNPSGPMPGPGPQQPQQRIPATMMGGPPLPGPPAVGPPSVPSGMMGPQQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQLQQVQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQQQQAQQQRLHQQQLLMQQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
Length1127
PositionUnknown
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.04
Grand average of hydropathy-0.642
Instability index66.69
Isoelectric point9.15
Molecular weight121743.53
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11906
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     310.51|      39|      39|     515|     553|       1
---------------------------------------------------------------------------
  473-  531 (41.81/ 7.35)	TTSLTSATGMgtvMSSQASHqnfqgggmkappqqggMM..VGG.......gQ.SG......MM.TSQPNMMTPQ........Q...Q
  532-  565 (39.08/ 6.26)	QHMMTSQSNL...MSSQASN................MM..MTS.......sQ.SN......IMpSSQPN..................
  566-  606 (46.51/ 9.24)	..LMSSQMNM...GNSQISQ................PG..MMS.......tQ.GG......MM.TSQQQQQQPQ........QpggP
  622-  663 (50.92/11.01)	NNMMPAQNNM...GPSQ.SD................MM..TQGgmyqnpnmQ.SG......LR.NPGP....PQ........S...R
  857-  893 (49.92/10.61)	QQ.MKMQQQL.....QQ.RG................MMnqMAG........GvQQ......PP.QSQPGMQTPQ........Q....
 1015- 1056 (41.41/ 7.20)	QQLQQVQQQ......QQRLQ....................LQQ........Q.QQ......QQ.QQQQNPSNPQlkqilinqQ...Q
 1057- 1093 (40.86/ 6.97)	QQ...AQQQR...LHQQ..Q................LL..MQQ........Q.QQqqqqqlPR.GPGPQGM...........G...Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.66|      32|      32|     298|     329|       2
---------------------------------------------------------------------------
  275-  319 (41.09/ 9.22)	GdSGFRIPVPAsvsaqqpqeasvSQSSAPQPTTRPTGPVTSQPPL
  320-  347 (35.61/ 6.84)	M.SQIRSPISQ...........tQTSSAPGPPHISSGPGT.....
  895-  922 (43.95/10.46)	M.GQ....ADQ............FNPSGPMPGPGPQQPQQRIPAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.40|      24|      32|     370|     397|       4
---------------------------------------------------------------------------
  370-  393 (43.68/12.97)	MGLQRHPPPNVLASTQ.AQQLTTTL
  404-  428 (35.01/10.94)	MILEQTKPGNIRPSSQfTQQLQQQQ
  945-  967 (33.71/ 7.22)	MGPQQVSNVN.QMGMA.GGGLTISD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.31|      12|      33|     253|     264|       5
---------------------------------------------------------------------------
  253-  264 (19.51/12.48)	SVLASAPTAATV
  286-  297 (20.80/13.97)	SVSAQQPQEASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.97|      15|      15|     981|     995|       7
---------------------------------------------------------------------------
  981-  995 (23.85/13.77)	QRALAAAQAKEKQFQ
  997- 1011 (25.12/14.89)	QRQIDEARAQHTLVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.37|      21|      35|     715|     735|       8
---------------------------------------------------------------------------
  715-  735 (36.26/20.72)	WQEKTKTGNTTDPGAKIIRSL
  753-  770 (30.09/15.92)	WPNKLQMQLI..PQA.ILQSL
  775-  795 (29.03/15.10)	RNSRTVSFQFANTDKEAIKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.57|      26|      56|     159|     186|       9
---------------------------------------------------------------------------
  159-  185 (43.20/26.84)	GYNAeDLAHMMGQRGINLSVISP............RKIP
  203-  240 (39.37/16.32)	DYTI.DPRHLVLLRGYSLQERPPspggdkiqdksiQKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.04|      12|     427|     671|     684|      10
---------------------------------------------------------------------------
  671-  683 (20.70/13.37)	QPGvPMGQMANQP
  688-  699 (23.34/ 6.21)	MAG.PGGGLLDNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.64|      21|     572|     348|     369|      12
---------------------------------------------------------------------------
  348-  369 (36.05/16.86)	MLQQHPTSiAPPASQPTSAASG
  923-  943 (44.59/18.34)	MMGGPPLP.GPPAVGPPSVPSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.40|      12|      25|     796|     807|      15
---------------------------------------------------------------------------
  796-  807 (21.51/13.75)	YKILSQGFAGYI
  824-  835 (20.89/13.16)	YSTKMKKFVGLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11906 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KTMQQMKMQQQLQQRGMMNQMAGGVQQPPQSQPGMQTPQQMMGQADQFNPSGPMPGPGPQQPQQRIPATMMGGPPLPGPPAVGPPSVPSGMMGPQQVSNVNQMGMAGGGLTISDQERQANLSTIPMLQRALAAAQAKEKQFQTQRQIDEARAQHTLVQQRQQQL
2) QQQQQQQQQQLPRGPGPQGMGQGMGQPGMQQSGMGQMGQLGQSQPFGDGFDLESLL
3) RGYSLQERPPSPGGDKIQDKSIQKLPAKVGSPAAGSASSVLASAPTAA
4) SLGDSGFRIPVPASVSAQQPQEASVSQSSAPQPTTRPTGPVTSQPPLMSQIRSPISQTQTSSAPGPPHISSGPGTMLQQHPTSIAPPASQPTSAASGMGLQRHPPPNVLASTQAQQLTTTLKGQNAKEVTKMILEQTKPGNIRPSSQFTQQLQQQQQQQQGMQPGPGPPLSQQPGLHMPPVSQPLPMASYQSQLPTQSQPTTSLTSATGMGTVMSSQASHQNFQGGGMKAPPQQGGMMVGGGQSGMMTSQPNMMTPQQQQHMMTSQSNLMSSQASNMMMTSSQSNIMPSSQPNLMSSQMNMGNSQISQPGMMSTQGGMMTSQQQQQQPQQPGGPQNVMVSQQNMMAQSQNNMMPAQNNMGPSQSDMMTQGGMYQNPNMQSGLRNPGPPQSRMPMQSNVQPGVPMGQMANQPLDMLMAGPGGGLLDNPASRA
5) VQQQQQRLQLQQQQQQQQQQQNPSNPQLKQILINQQ
854
1072
215
273
1020
1017
1127
262
703
1055










Molecular Recognition Features






MoRF SequenceStartStop




1) QPFGDGFDLESLL
1115
1127