<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11903

Description cyclin-dependent kinase 8 isoform X3
SequenceMAMSIKPEEKNSDGREYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRAAKANKKPVNVPRNFVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHPTLMKDFKKSSYVNCTLTKYMEKHKVHPDSKAFRLLQKLLTMDPTKRITSEQAMQDAYFMEDPSPCPDVFEGLPIPYPKREFITDDEPTNDNEKSDNASKATGGNDQSSSHGQPPAKRVRVMQPNTNNGTMVSNEYQRNVHGMPGNQGQQHSYSSTQSTQGTNSTVYGQTRF
Length416
PositionKinase
OrganismLingula unguis
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Brachiopoda> Linguliformea> Lingulata> Lingulida> Linguloidea> Lingulidae> Lingula.
Aromaticity0.09
Grand average of hydropathy-0.629
Instability index42.85
Isoelectric point8.39
Molecular weight47663.78
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11903
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.85|      32|      36|     265|     300|       1
---------------------------------------------------------------------------
  265-  300 (46.68/43.99)	MEKHKVHPDskAFRLLQklLTMDPTKRITSEQAMQD
  304-  335 (61.17/42.81)	MEDPSPCPD..VFEGLP..IPYPKREFITDDEPTND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.79|      20|      40|     336|     355|       2
---------------------------------------------------------------------------
  336-  355 (33.88/22.28)	NEKSDNASKATGGNDQSSSH
  378-  397 (38.91/26.60)	NEYQRNVHGMPGNQGQQHSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      36|     119|     133|       3
---------------------------------------------------------------------------
  119-  133 (26.77/16.06)	DLKPANILVMGEGPE
  157-  171 (28.67/17.64)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11903 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VFEGLPIPYPKREFITDDEPTNDNEKSDNASKATGGNDQSSSHGQPPAKRVRVMQPNTNNGTMVSNEYQRNVHGMPGNQGQQHSYSSTQSTQGTNSTVYGQTRF
313
416










Molecular Recognition Features






MoRF SequenceStartStop




NANANA